Indoor spectroradiometric characterization of plastic litters commonly polluting the Mediterranean Sea: toward the application of multispectral imagery.

Around 350 million tonnes of plastics are annually produced worldwide. A remarkable percentage of these products is dispersed in the environment, finally reaching and dispersed in the marine environment. Recent field surveys detected microplastics' concentrations in the Mediterranean Sea. The most commonly polymers found were polyethylene, polypropylene and viscose, ethylene vinyl acetate and polystyrene. In general, the in-situ monitoring of microplastic pollution is difficult and time consuming. The main goals of this work were to spectrally characterize the most commonly polymers and to quantify their spectral separability that may allow to determine optimal band combinations for imaging techniques monitoring. The spectral signatures of microplastics have been analysed in laboratory, both in dry condition and on water surface, using a full spectrum spectroradiometer. The theoretical use of operational satellite images for remote sensing monitoring was investigated by quantifying the spectral separability achievable by their sensors. The WorldView-3 sensor appears the most suitable for the monitoring but better average spectral separability are expected using the recently released PRISMA images. This research was preparatory to further outdoor experiments needed to better simulate the real acquisition condition.

Referential communication skills in children with Down Syndrome.

AIM: The aim of this study was to investigate referential communication skills in children with Down Syndrome (DS). We studied the development of pragmatic language in relation to nonverbal skills by analyzing referential communication skills in children with DS, in both production and comprehension of referential messages: oriented and/or ambiguous, adequate (appropriate) and inadequate (inappropriate). METHODS: The study population was 24 children: 12 with DS (mean age, 7.8 years) and 12 with normal development (control group) (mean age, 7.4 years). In the first phase (F1), all 24 children were administered a test to evaluate their nonverbal skills, followed in a second phase (F2) by a test to specifically evaluate their referential communication skills. RESULTS: A strong relationship between nonverbal and referential communication skills was found, in which the nonverbal skills contributed to variations in referential performance, especially among the children with DS. Furthermore, the children with DS showed better performance in the "talking" than the "listener" condition. Within the listener condition, a significant correlation emerged between adequate and inadequate messages. CONCLUSION: Referential communication skills are influenced by several verbal and nonverbal factors.

Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.

The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but statistically significant higher concentration of the active drug metabolite (cloricromene acid) in the brain compared with the parent drug administered by the same way. The correlation between pharmacokinetic data and calculated partition (LogP) and brain distribution coefficients (LogBB) supported the hypothesis that the amphiphilic nature of the LAA promoiety could be responsible for a better penetration into the brain, more than the simple increase of lipophilicity gained with respect to the parent drug.

Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.

Polymeric nanoparticle suspensions were prepared from Eudragit RS100R and RL100R polymer resins and loaded with flurbiprofen (FLU), with the aim at improving the availability of the drug at an intra-ocular level for the prevention of the myosis induced during extracapsular cataract surgery. Nanosuspensions were prepared by a quasi-emulsion solvent diffusion technique using different formulation parameters (drug-to-polymer ratio, initial polymer concentration, agitation speed, etc.). The resulting nanoparticles showed mean sizes around 100 nm and a fixed positive charge (zeta-potential around +40/+60 mV). Stability tests after mid-time storage (4 degrees C or room temperature) or freeze-drying were carried out to optimise a possible final pharmaceutical preparation. In vitro, dissolution tests showed a controlled release profile of FLU from the nanoparticles. In vivo anti-inflammatory efficacy was assessed in the rabbit eye after induction of an ocular trauma (paracentesis). FLU-loaded nanosuspensions did not show toxicity on ocular tissues. Moreover, an inhibition of the miotic response to the surgical trauma comparable to a control eye-drop formulation was obtained, even though an actual lower concentration of free drug in the conjunctival sac was achieved from the nanoparticle system. Drug levels in the aqueous humour were also higher after application of the nanosuspensions.

[Time, memory, institution. Analysis of past experiences which emerge at times of crisis as a memory tract in the staff of a nursing home for the aged]. / Il tempo, la memoria, l'istituzione. Analisi del vissuto regressivo che emerge nel momento di crisi come traccia della memoria in operatori di una casa di riposo protetta.

The paper analyses the feelings of the staff of an old people's home. Following an identification crisis, the group faced a massive regression. An attempt was made to solve this problem by dividing the staff into teams, each of which was entrusted with a group of old people for whose needs they would be entirely responsible. After two years, the staff were faced with problems which had previously seemed resolved. Old people in poor health were not respected as individuals. They were called by name and treated with familiarity; they were kept in bed to prevent them falling, and had to perform all their bodily functions in bed. Rebellious attitudes and depressive states were underestimated and ascribed to arteriosclerosis. An attempt was made to understand the reasons behind this regression. Small discussion groups were formed in order to reestablish the group's memory track which reorganisation and change had caused.

PET and P300 relationships in early Alzheimer's disease.

The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer's disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas.

A double-blind controlled subjective study of a new pharmaceutical preparation of lormetazepam versus placebo in patients with chronic sleep disturbances.

A double-blind crossover trial was carried out on the sleep-inducing activity of a new preparation (oral drops) of lormetazepam versus placebo. Twenty patients were included and requested to subjectively evaluate their sleep, both by analogue scales and semiquantitative ratings, during 2-night administration of the two products. Also, the usual parameters, sleep duration, sleep latency and number of awakenings were evaluated. Lormetazepam drops appeared to exert the same actions as the capsules' preparation, being significantly different from those of the placebo.