[The role of the lungs in regulating the generation of active forms of oxygen by the phagocytes, the concentration of immunoglobulins and the complement activity]. / Rol' legkikh v reguliatsii generatsii aktivnykh form kisloroda fagotsitami, soderzhaniia immunoglobulinov i aktivnosti komplementa.

Experiments on 25 intact dogs, 2 calves and clinical tests in 45 patients have shown that in the blood of the aorta or pulmonary vein leaving the lungs there is a rise in generation of active oxygen forms by leukocytes, their phagocytic activity, the activity of myeloperoxidase, NADPN-oxidase, complement, immunoglobulins content. As to the liver, kidneys, spleen, no such increased generation of active oxygen forms by leukocytes was registered. The results suggest an important role of the lungs in regulation of free radical activity of leukocytes, their phagocytic ability and thus in anti-infection defense of the body.

[Indirect electrochemical oxidation of blood in multimodal intensive therapy of pneumonia in critical patients]. / Nepriamoe élektrokhimicheskoe okislenie krovi v kompleksnoi intensivnoi terapii pnevmonii u bol'nykh v kriticheskom sostoianie.

Seventy-five patients with severe pneumonia were treated with sodium hypochlorite solution (intravenous drip in concentration 600 mg/liter). Beneficial effect of the treatment manifested with lowering of body temperature, diminution of tachycardia, leukocytosis, leukocytic intoxication index. The patients recovered 5-7 days earlier, the mortality reduced by 11%. Better clinical parameters were due rather to stimulation of anti-infection defence than to direct detoxication action of sodium hypochlorite on the causative agent and toxic products. The solution is recommended for treatment of critical pneumonia as an effective modality with immunostimulating, antiinfectious and detoxication abilities.

[The use of xenogeneic splenic perfusates for treating suppurative-septic diseases]. / Ispol'zovanie ksenosplenoperfuzatov dlia lecheniia gnoino-septicheskikh zabolevanii.

It was shown in experiments on a model of fatal staphylococcal sepsis in 200 mice and 15 dogs that the perfusate of a pig's spleen obtained by perfusion of the isolated organ with a dextran solution (rheopolyglucin, polyglucin) is capable of preventing the animals' death. Intravenous infusion of 400-500 ml of a xenospleen perfusate at an interval of 1-3 days, which was included in the complex of postoperative treatment of 45 patients with destructive diseases of the abdominal organs complicated by peritonitis and sepsis, contributed to reduction of lethality and the terms of recovery. It is shown that the main effect, besides detoxification, is based on immunomodulation at the cost of biologically active substances produced by the cells of a xenospleen and contained in the perfusate. The best results were produced with the use of the perfusate of a xenospleen in the early periods after radical operation and thorough cleansing of the source of the infection.

[Role of the lungs in the regulation of the generation of active oxygen forms by leukocytes under normal and pathological conditions]. / O roli legkikh v reguliatsii generatsii aktivnykh form kisloroda leikotsitoami v norme i patologii.

Studies conducted in the clinic (in patients with cardiac diseases) and experiments (performed on intact dogs) by means of the hemiluminescent method and the nitroblue tetrazolium test showed that the lungs, in distinction to other organs (heart and others), have a stimulating effect on the generation of active oxygen forms (AOF) by the leukocytes. In this way the lungs may probably play a double role in the organism: potentiate its defence (by intensifying the microbicidal activity of the phagocytes) and facilitate damage (by secretion of AOF by the phagocytes beyond them--into the tissues); the resultant effect depends on the balance of these two types of action. In carcinoma of the lung the stimulating effect of its involved lobe (part) on the leukocytes diminishes.

[The generation of active microbicidal forms of oxygen by leukocytes transiting the vascular bed of the lungs]. / Generatsiia aktivnykh mikrobotsidnykh form kisloroda leikotsitami pri prokhozhdenii cherez sosudistoe ruslo legkikh.

In experiments on dogs using the chemiluminescent method and nitroblue-tetrazole reaction the authors found out that leucocytes while passing through the pulmonary vessels bed, in contrast to the spleen increase the generation of active microbicidal forms of oxygen. Due to this fact we suppose that the lungs may take part in the formation of free radical status and phagocytic antiinfectious defence of the organism.