1.
Chem Sci
; 10(38): 8792-8798, 2019 Oct 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31803451
RESUMO
Stereoselective ß-C(sp2)-H alkylation of enamides with redox-active N-hydroxyphthalimide esters via a photoredox-catalyzed decarboxylative cross-coupling reaction is demonstrated. This methodology features operational simplicity, broad substrate scopes, and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory yields.