[Interrelation between antioxidant hepatoprotective action of some derivatives of monochromanes and trimethylphenols and energy structural quantum-chemical parameters].

Energy and structural parameters of monochromanes and trimethylphenols derivatives have been chracterized through the employment of semiempirical methods of quantum chemistry. The correlation has been proved between antiradical, hepatoprotective properties of these compounds and energy and structural of their molecules that confirms the presence of relation between structure activity and electron-donor properties of the investigated monochromanes and trimethylphenols.

[The influence of N-, S-containing chinasolone derivatives (NC-224) on the biochemical and physicochemical parameters of membrane endoplasmatic reticulum and nuclear chromatine fractions of rats liver cells in conditions of its injury by tetrachloromethane].

Using biochemical and physicochemical methods of investigation in vivo, the effect of the substance NC-224, N-, S-chinasolone-derivative, on the lipoperoxidation activity in rat liver endoplasmatic reticulum membranes and nuclear chromatin fractions under tetrachloromethane intoxication have been studied. It was shown that NC-224 has pronounced antioxidant activity which is the biochemical basis of the substance membrane- and genome-protective effects and its ability to restore physicochemical properties of the surface and hydrophobic zones of hepatocyte membranes and structural parameter nuclear chromatin fractions in the conditions of chemical liver injury.

[Biochemical mechanisms of genome-protective activity of pyridine carbonic acid new derivatives with cells damaged by tetrachloromethane]. / Biokhimichni mekhanizmy henomozakhysnoï diï novykh pokhidnykh pirydynkarbonovykh kyslot za urazhennia klityn tetrakhlormetanom.

The biochemical mechanisms of genomoprotective action of the new derivatives of pyridinecarbonic acids--PV-3, PV-4 and PV-6 in the conditions of tetrachloromethane chemical cell damage have been studied. This effect is related to their antioxidant influence on LPO processes in transcriptionally active and repressed chromatin fractions of rat liver cells and partial restoration of these fractions structure which has been destroyed during intoxication. PV-4 possesses the most genoprotective activity among the substances studied.

[Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin]. / Korihiuchyi vplyv korotkolantsiuhovoho pokhidnoho vitaminu E na stan protsesiv POL ta strukturuu membran i khromatynu klityn pechinky shchuriv za diï embikhinu.

Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.

[Effect of amizon on structural modifications of liver nuclear chromatin from rats, intoxicated with tetrachloromethane]. / Vplyv amizonu na strukturnu modyfikatsiiu iadernoho khromatynu pechinky shchuriv, intoksykovanykh tetrakhlormetanom.

The actions of the amizon on the antioxidant activity and free radicaloformation level in the nuclear chromatin fractions of rat liver methan tetrachlorid intoxication was studied using the Fe(+2)-induction biochemiluminescence and microcalorimetry methods. The amizon genomoprotective effect on the chromatin transcriptionally active fraction was shown.