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1.
J Laryngol Otol ; 137(6): 629-636, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35924453

RESUMO

OBJECTIVE: The heterogeneity of Ménière's disease is presently defined by a variety of subtypes. This study introduced three different subtypes of unilateral Ménière's disease based on the evolution of vertigo crises from their inception. METHOD: A longitudinal descriptive study of 327 unilateral Ménière's disease patients was performed. In a subgroup of patients followed from the onset of the disease, 3 subtypes of unilateral Ménière's disease were defined according to the vertiginous crises suffered during the first 10 years of the disorder. RESULTS: Data was available for 87 patients with unilateral Ménière's disease from the start of their disease (26.6 per cent of the original sample). These patients were grouped into three models according to their symptomatic evolution. Model 3 was associated with a worse hearing prognosis, a greater number of Tumarkin's otolithic crises and the need for surgery. Model 1 presented less hearing loss. CONCLUSION: Unilateral Ménière's disease models based on the evolution of vertiginous crises present differences according to aspects such as hearing loss, vertiginous crisis, Tumarkin's otolithic crisis and the need for surgery.


Assuntos
Perda Auditiva , Doença de Meniere , Humanos , Doença de Meniere/diagnóstico , Doença de Meniere/epidemiologia , Doença de Meniere/complicações , Estudos Longitudinais , Vertigem/etiologia , Perda Auditiva/complicações , Membrana dos Otólitos
2.
J Laryngol Otol ; 137(7): 782-788, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36200516

RESUMO

OBJECTIVE: Bilateral Ménière's disease is classified according to the time of appearance of symptoms in each ear into synchronous and metachronous types. A descriptive longitudinal study, involving 59 bilateral Ménière's disease patients, was carried out to assess the two forms of bilateral Ménière's disease. METHOD: Data on symptomatic chronology in each ear, auditory evolution and evolution of vertiginous crisis, among other aspects, were obtained, analysed and compared. Possible risk factors for Ménière's disease becoming bilateral were analysed after conducting nested case-control studies in a cohort. RESULTS: The metachronous form was seen in 76.3 per cent of cases, and the time it took for the disease to become bilateral took a median time of seven years. The symptomatic triad was the most frequent symptomatic debut for the first ear in both forms. Synchronous debut presented a greater average hearing loss. Suffering from migraine and a symptomatic onset with a greater number of symptoms appear to be possible predictors of conversion to bilateral Ménière's disease. CONCLUSION: Bilateral Ménière's disease temporal models presented differences. The study of them helps to better understand, prevent and predict the behaviour of these patients.


Assuntos
Hidropisia Endolinfática , Doença de Meniere , Humanos , Doença de Meniere/diagnóstico , Doença de Meniere/epidemiologia , Estudos Longitudinais , Vertigem , Estudos de Casos e Controles
3.
Rev Neurol ; 68(8): 326-332, 2019 Apr 16.
Artigo em Espanhol | MEDLINE | ID: mdl-30963529

RESUMO

INTRODUCTION: Vertigo and dizziness are symptoms with a significant burden in the hospital and involve several specialties. There are few guidelines of radiological tests for these symptoms. AIMS: To know which profile of patients with vertigo and dizziness has neuroimaging tests, quantify and describe the radiological findings. To analyze the cost-utility of CT and MRI in the study of these patients. PATIENTS AND METHODS: Descriptive study, we selected patients referred to the hospital for vertigo and dizziness. We analyze demographic and clinical characteristics and quantify the neuroimaging tests requested. We describe the radiological findings, assess their relevance in the diagnosis and detail the cost-benefit. RESULTS: We identified 493 patients, those with neuroimaging test (60%) are older, depressed and frequented the emergency department because of vertigo. The most requested test was the cranial CT scan (5% identifies the cause of the symptom). MRI of the inner ear and cerebellopontine angle was the test that presented the most significant findings (17.7%). The 286 image tests requested for vertigo cost 56,741 euros. The cost for a positive test was 1,576 euros. CONCLUSIONS: A large number of head CT and MRI are made in patients with vertigo and dizziness. A clinical suspicion is recommended from the anamnesis and exploration to make a good selection of test to request. In more than 90% of cases, radiological findings are not shown in relation to vertigo.


TITLE: Que aporta la neuroimagen en pacientes con vertigo y mareo? Analisis coste-utilidad.Introduccion. Vertigo y mareo son sintomas que suponen una carga significativa en el hospital e involucran a varias especialidades. Existen pocas guias sobre la solicitud de pruebas radiologicas ante estos sintomas. Objetivos. Conocer que perfil de pacientes con vertigo y mareo tiene realizadas pruebas de neuroimagen, cuantificar y describir los hallazgos radiologicos, y analizar el coste-utilidad de la tomografia computarizada (TC) y la resonancia magnetica (RM) en pacientes con estos sintomas. Pacientes y metodos. Estudio descriptivo en el que se seleccionan pacientes remitidos al hospital por vertigo y mareo. Se analizan caracteristicas demograficas y clinicas y se cuantifican las pruebas de neuroimagen solicitadas. Se describen los hallazgos radiologicos, se valora su relevancia en el diagnostico y se detalla el coste. Resultados. Se identifica a 493 pacientes, el 60% tiene realizada una prueba de neuroimagen; son pacientes de mas edad, depresivos y que han acudido a urgencias por vertigo. La prueba mas realizada fue la TC de craneo sin contraste (el 5% identifica la causa del sintoma). La que presento mas hallazgos significativos fue la RM de la base del craneo (17,7%). Las 286 pruebas de imagen solicitadas por vertigo costaron 56.741 euros. El gasto para obtener un diagnostico radiologico fue de 1.576 euros. Conclusiones. Se realiza un gran numero de TC y RM de cabeza en pacientes con vertigo y mareo. Es recomendable tener un diagnostico de sospecha previo a partir de la anamnesis y la exploracion para hacer una buena seleccion de las pruebas que hay que solicitar. En mas del 90% de los casos no se muestran hallazgos radiologicos en relacion con el vertigo.


Assuntos
Tontura/diagnóstico por imagem , Imageamento por Ressonância Magnética , Tomografia Computadorizada por Raios X , Vertigem/diagnóstico por imagem , Adulto , Idoso , Encéfalo/diagnóstico por imagem , Meios de Contraste/economia , Análise Custo-Benefício , Diagnóstico Diferencial , Tontura/economia , Tontura/etiologia , Serviço Hospitalar de Emergência/economia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Feminino , Humanos , Imageamento por Ressonância Magnética/economia , Masculino , Pessoa de Meia-Idade , Neuroimagem/economia , Neuroimagem/métodos , Osso Petroso/diagnóstico por imagem , Utilização de Procedimentos e Técnicas/economia , Estudos Retrospectivos , Base do Crânio/diagnóstico por imagem , Espanha , Tomografia Computadorizada por Raios X/economia , Procedimentos Desnecessários/economia , Vertigem/economia , Vertigem/etiologia
4.
An Pediatr (Barc) ; 65(1): 37-43, 2006 Jul.
Artigo em Espanhol | MEDLINE | ID: mdl-16945289

RESUMO

OBJECTIVE: To evaluate the clinical and epidemiologic characteristics in children with peritonsillar infections. PATIENTS AND METHODS: A longitudinal retrospective study was performed through a review of the clinical histories of patients attending the emergency unit in the previous 6 years. The variables gathered were age, sex, recurrent tonsillitis, previous upper airway infection, antibiotic administration, and therapeutic approach. RESULTS: Twenty-nine children were admitted, with a mean age of 7.4 +/- 1.6 years (boys 1.6:1). Twenty-seven percent had recurrent tonsillitis. At the visit, 57.8 % had an upper respiratory infection and 65 % were taking antibiotic treatment, especially macrolides. The treatment selected at our center consisted of the association of penicillin or amoxicillin-clavulanate acid with clindamycin, including corticosteroids. Ten children underwent computed tomography and nine underwent fine-needle aspiration. Drainage was performed in 20.6 % of confirmed abscesses. The mean length of hospital stay was 5.6 +/- 1.6 days. Delayed tonsillectomy was performed in 31 %, except in one patient who developed a parapharyngeal abscess. Currently, 18.9 % of all peritonsillar infections occur in the pediatric population. CONCLUSIONS: The increase in these infections is probably related to inappropriate use of antibiotics in respiratory diseases. Diagnosis is clinical, and infections are often resolved by intravenous administration of beta-lactams with clindamycin and an expectant attitude. When an abscess is suspected or there is no clinical improvement, fine-needle aspiration or computed tomography is warranted and drainage should be performed if an abscess is confirmed. Tonsillectomy, usually delayed, is only indicated in patients with recurrent tonsillitis.


Assuntos
Abscesso Peritonsilar/epidemiologia , Tonsilite/epidemiologia , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Abscesso Peritonsilar/terapia , Estudos Retrospectivos , Tonsilectomia , Tonsilite/terapia
5.
Acta Otorrinolaringol Esp ; 57(5): 204-9, 2006 May.
Artigo em Espanhol | MEDLINE | ID: mdl-16768197

RESUMO

INTRODUCTION: To evaluate the therapeutic response and the rheologic and immunological characteristics in subjects bearing of rapidly progressive sensorineural hearing loss (RPSHL). PATIENTS AND METHODS: A comparative prospective study on three groups of damaged ears treated with piracetam (n=29), corticosteroids (n=32) and plabcebo (n=25). Hearing loss and recovery level, whole blood filterability (WBF) and a Western-blot (WB) to anticochlear antibodies were evaluated. RESULTS: Recovery average was 20,8 +/- 55,9% in the first group, with progressive of deafness in the rest (p<0,01). WB did not show differences among groups. The higher WBF at the end of therapy was detected on group 1 (20,36 +/- 2,54 Vs 18,42 +/- 3,42 microl/seg on group 3; p<0,05). Moreover, it impaired only on those treated with piracetam, with statistically significative differences over the other two groups. CONCLUSIONS: We detected alterations on WBF in patients with RPSHL that justify the use of rheoactive measures as a pathophysiological therapy.


Assuntos
Corticosteroides/uso terapêutico , Perda Auditiva Neurossensorial/tratamento farmacológico , Piracetam/uso terapêutico , Adulto , Viscosidade Sanguínea , Progressão da Doença , Método Duplo-Cego , Feminino , Perda Auditiva Neurossensorial/sangue , Perda Auditiva Neurossensorial/etiologia , Perda Auditiva Neurossensorial/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Tempo
6.
Acta Otorrinolaringol Esp ; 57(5): 199-203, 2006 May.
Artigo em Espanhol | MEDLINE | ID: mdl-16768196

RESUMO

OBJECTIVE: The purpose of this study is the identification of susceptible individuals to develop noise induced hearing loss. For it we use the capacity of the transitory otoacoustic emissions (TEOAE) for the identification of functional alterations at different levels from the auditory system. MATERIAL AND METHODS: 67 normal hearing subjects have been studied, we have recorded TEOAE in one ear in three different conditions: in normal conditions (SIN register), simultaneously to the stimulation of the contralateral cochlea (EAC register), and after stimulation we can observe (EAI register). We compare the amplitude of the TEOAE with the SIN and EAC registers to quantity the contralateral suppresor effect, and the SIN and EAI, register to study the auditory fatigue. RESULTS: We can observe a reduction in the amplitude of the TEOAE obtained by acoustic stimulation of the ipsilateral ear (0.954 dB SPL), or after the ipsilateral acoustic stimulation (0.75 dB SPL), being able to see an inverse correlation between both values. CONCLUSIONS: The study of the TEOAE obtained in different conditions of acoustic stimulation, ipsilateral or contralateral, and the inverse correlation obtained between the magnitude of the auditory fatigue and the contralateral suppresor effect, provides arguments for the identification of individuals susceptible of developing noise induced hearing loss.


Assuntos
Fadiga Auditiva , Emissões Otoacústicas Espontâneas , Adolescente , Adulto , Feminino , Humanos , Masculino
7.
Acta Otorrinolaringol Esp ; 57(4): 196-8, 2006 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-16686232

RESUMO

We developed a two year follow-up in thirteen subjects bearing of fluctuant sensorineural hearing loss measuring their blood filterability (BF) and making a correlation to appearance of deafness episodes. We could observe a decrease on BF in all patients when they felt a hearing loss. When they recovered the hearing level, BF increased too. The use of reoactive techniques to avoid these decreases on BF in fluctuant deafness could potentially prevent or improve them.


Assuntos
Cóclea/irrigação sanguínea , Cóclea/fisiopatologia , Perda Auditiva Neurossensorial/fisiopatologia , Audiometria de Tons Puros/métodos , Perda Auditiva Neurossensorial/diagnóstico , Hemodinâmica/fisiologia , Hemofiltração/instrumentação , Humanos , Índice de Gravidade de Doença
8.
Acta Otorrinolaringol Esp ; 57(1): 28-33, 2006 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-16503030

RESUMO

OBJECTIVES: To value if the sensorineural hearing loss (SHL) in several autoimmune diseases (AD) is also secondary to immunomediation. PATIENTS AND METHODS: In 342 cases with SHL and any AD and 301 normoacoustic controls with AD a non-specific immunologic battery of tests and a Western-blot (WB) for anticochlear autoantibodies were developed, and cases with SHL were treated with deflazacort. RESULTS: Alterations in non-specific battery were similar between cases and controls. But a 12,5% of cases with SHL and a 1,6% of normoacoustic showed a positive WB (p<0,001). Steroid therapy improved hearing in 14,3% of cases. In them, sensitivity and specificity of non-specific battery were 78,4% and 75,5%, respectively, to predict response to therapy. These were 98,9% and 81,6% for WB. CONCLUSIONS: The SHL in cases with AD can be considered immunomediated in a discrete average, but the diagnostic efficiency of WB to predict an improvement after steroid therapy is high.


Assuntos
Doenças Autoimunes/epidemiologia , Western Blotting , Perda Auditiva Neurossensorial/epidemiologia , Perda Auditiva Neurossensorial/imunologia , Adulto , Anticorpos/imunologia , Audiometria de Tons Puros/métodos , Doenças Autoimunes/sangue , Doenças Autoimunes/imunologia , Técnicas de Laboratório Clínico , Cóclea/imunologia , Comorbidade , Feminino , Humanos , Imunoglobulina A/sangue , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Masculino
9.
Acta Otorrinolaringol Esp ; 57(2): 90-5, 2006 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-16550861

RESUMO

OBJECTIVE: To value a possible association between disorders in blood viscosity of patients with rapidly progressive sensorineural hearing loss (RPSHL) of autoimmune origin. PATIENTS AND METHODS: We studied the viscoelastic properties of blood in 43 subjects bearing of RPSHL and a positive Western-blot for anticochlear antibodies: whole blood viscosity (WBV) at different shear rates and erythrocyte filterability (EF). These results were related to hearing loss initially detected and recovery average one year later from steroid therapy. RESULTS: Just WBV at 230 sec(-1) shear rate was significatively higher in cases than in controls (p < 0.01). Hearing recovery degree correlated in an statistically way to increased values of EF (p < 0.01). There was no relation between initial hearing loss level and any rheology parameter. CONCLUSIONS: Autoimmune RPSHL does not show a pathophysiology mechanism associated to blood hyperviscosity. So, rheoactive therapies as plasmapheresis warrant no clinical improvement.


Assuntos
Anticorpos Antinucleares/genética , Viscosidade Sanguínea , Western Blotting/métodos , Perda Auditiva Neurossensorial/genética , Perda Auditiva Neurossensorial/fisiopatologia , Adulto , Anti-Inflamatórios/uso terapêutico , Progressão da Doença , Feminino , Perda Auditiva Neurossensorial/tratamento farmacológico , Humanos , Masculino , Pregnenodionas/uso terapêutico , Índice de Gravidade de Doença
10.
Acta Otorrinolaringol Esp ; 57(10): 450-4, 2006 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-17228644

RESUMO

OBJECTIVE: To review the petrous bone fractures during the last five years (1999-2004) in our hospital, its manage, control, and analysis onf the associated factors. To analyse the managing protocoles and current bibliography. MATERIAL AND METHODS: We review 266 temporal bone fractures, 74 with petrous bone association. We analyse these fractures by sex distribution, injurie severity, otorhinolaryngological clinical findings, production mechanism and radiological findings. The cases are discussed and compared with current bibliography. CONCLUSIONS: Petrous bone fractures must be always suspected in patients with head trauma, specially if it associates severity and otorrhagia. It is necessary a deep colaboration between neurosurgeons, radiologists and otorhinolaryngologists to obtain a good management, control and follow up of the patients.


Assuntos
Fraturas Ósseas/epidemiologia , Osso Petroso/lesões , Feminino , Fraturas Ósseas/diagnóstico por imagem , Humanos , Incidência , Masculino , Osso Petroso/diagnóstico por imagem , Prevalência , Estudos Retrospectivos , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X
11.
Acta Otorrinolaringol Esp ; 56(9): 423-7, 2005 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-16353789

RESUMO

OBJECTIVE: To investigate the oncological efficiency, voice and complications of Pearson's near-total laryngectomy for advanced laryngeal cancers (T3, T4). MATERIAL AND METHODS: A retrospective review of 23 cases of near-total laryngectomy (carried out in our Hospital in the last nine years) was undertaken. RESULTS: None of the cases developed laryngeal mucosal recurrences. The overall three and five years disease free survival were 91,3% and 86,9%. Mean phonation time was 51 days. A statistically significant results were observed in our voice analysis (words/minute, taking as a reference healthy people (Medivoz). The pharyngeal fistula was the most frequent complication (60,86%). CONCLUSIONS: The local control of cancer was similar to that expected with total laryngectomy. Near-total laryngectomy is a valid alternative for extended laryngeal and neighbouring cancers with an acceptable morbidity and success rate for voice preservation.


Assuntos
Laringectomia/efeitos adversos , Laringectomia/métodos , Voz Alaríngea , Acústica , Adulto , Idoso , Desenho de Equipamento , Humanos , Laringectomia/instrumentação , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
12.
Acta Otorrinolaringol Esp ; 56(7): 295-9, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-16240918

RESUMO

INTRODUCTION: Hearing loss level admitted for acquisition of Group 2 driving licences is actually 35%, but this measurement is not standarized. METHODS: In 35 drivers with Group 2 licence bearing of hearing loss, it was measured in the usual way -considering threshold as an average-, and also in accordance with valid legislation, which considers deafness when hearing thresholds are under 25 dB in each tone. RESULTS: Binaural hearing loss average was 41.3+/-6.3% for the first model, and 30.7+/-10.2% for the second. There was a good correlation between the two models by mean of lineal regression (y=1.4785x-30.382; R2=0.8467). CONCLUSIONS: In Group 2 licences, hearing loss average must be standarized in its quantifyng technique, because there is a wide difference in the results, depending on the model used to measure. In our country there are rules and regulations about quantifying for disable people, valid for establishing deafness measurement patterns in vehicle driving too.


Assuntos
Condução de Veículo/legislação & jurisprudência , Transtornos da Audição/diagnóstico , Licenciamento/legislação & jurisprudência , Adulto , Audiometria/métodos , Limiar Auditivo/fisiologia , Transtornos da Audição/fisiopatologia , Humanos , Espanha
13.
Acta Otorrinolaringol Esp ; 56(6): 273-9, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-15999794

RESUMO

CSF leaks in the ear are the result of an abnormal communication between subarachnoid and tympano mastoid areas, most of then as a result of trauma (90%). They mean a lisk of meningitis (4-50%) directly related to the etiology. Our aim is to present the CSF leak cases seen in our hospital in the last 2 years and a revision of their management. The main factor for a sucessful surgical repair is to use a multilayer tecnhique with a sucess rate close to 100%.


Assuntos
Otorreia de Líquido Cefalorraquidiano/etiologia , Idoso , Antibacterianos , Otorreia de Líquido Cefalorraquidiano/tratamento farmacológico , Otorreia de Líquido Cefalorraquidiano/cirurgia , Quimioterapia Combinada/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias
14.
Acta Otorrinolaringol Esp ; 56(5): 187-91, 2005 May.
Artigo em Espanhol | MEDLINE | ID: mdl-15960120

RESUMO

INTRODUCTION: Wide studies and substantial controversies build on utilization of actual mobile phones and appearance of systemic disorders or even tumours, but there is no knowledge about an eventual involvement on early hearing loss. PATIENTS AND METHODS: In a group of three hundred and twenty-three healthy and normoacoustic volunteers who were usual costumers of mobile phones an audiometric evaluation was made at the beginnig of its use and three years later, inquiring about the periods of time per day and year employed on direct contacts with phone. A healthy and normoacoustic control group of non users was studied too. RESULTS: Cases carried out 24.3 +/- 8.2 active contacts, reaching 50.4 +/- 27.8 days of mobile phone employment in three years. Audiometric curve was similar in cases and controls at the beginning of the study. After this follow-up, cases showed an increase on hearing threshold between 1 and 5 dB HL more than controls in speech tones (p<0.001). Moreover, there was a trend to correlate time of phone use to hearing impairment, but this finding did not result statistically significative. CONCLUSIONS: Frequent management of mobile phones in a middle period of time allows to detect a mild hearing loss, but the cause of this disorder keeps unclear.


Assuntos
Telefone Celular , Campos Eletromagnéticos/efeitos adversos , Audição , Adulto , Audiometria de Tons Puros , Feminino , Humanos , Masculino
16.
Acta Otorrinolaringol Esp ; 56(2): 68-73, 2005 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-15782645

RESUMO

OBJECTIVE: To value the eventual immunomediation in sensorineural hearing loss (SHL) on patients bearing of ulcerative colitis (UC). MATERIAL AND METHODS: In a group of forty-nine cases with a mean age of 41.6+/-9.3 years old we studied the hearing loss level, the disease activity index, the peripheral blood inflammation markers and the anticochlear antibodies by mean of Western-blot technique (WB). RESULTS: The 26.5% knew about their deafness, although SHL was detected in 59.1% of cases. The mean age of onset was 40.3+/-9.8 years. 48.9% showed a positive WB, always in 68-70 kDa molecular weight blots. Moreover, patients with positive WB showed more severe deafness, higher disease activity and more altered parameters, especially erythrosedimentation rate. CONCLUSIONS: Audiologic and peripheral blood findings observed allow us to establish a reasonable suspicion of an autoimmune or immunomediated pathway of hearing loss on UC.


Assuntos
Colite Ulcerativa/complicações , Transtornos da Audição/etiologia , Adulto , Colite Ulcerativa/imunologia , Feminino , Transtornos da Audição/diagnóstico , Humanos , Imunoglobulina A/imunologia , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Masculino
17.
Acta Otorrinolaringol Esp ; 55(8): 356-63, 2004 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-15552210

RESUMO

OBJECTIVE: [corrected] To evaluate the existence of blood viscosity alterations in presbyacusis as an eventual pathophysiological mechanism. MATERIAL AND METHODS: Nine 75 year-old subjects bearing of bilateral slowly progressive sensorineural deafness were considered to be studied on a yearly basis in a ten year folow-up period, evaluating the binaural hearing loss in speech tones (500, 1000, 2000 and 3000 Hz). Hemorheological profile on peripheral blood included total blood viscosity (BV) at different shear rates (SR), blood filterability (BF), erythrocyte deformability and aggregability (EA). RESULTS: There was a trend of all parameters towards hyperviscosity, with an increase at ten years of BV at high SR and EA at total stasis which were statistically significant. The level of deafness correlated significativelly to low values of BF and increases on BV at high SR. CONCLUSIONS: Presbyacustic patients do show hemorheological evidences that suggest a tendency towards hyperviscosity as a predisposing factor for hearing loss.


Assuntos
Viscosidade Sanguínea , Presbiacusia/sangue , Idoso , Idoso de 80 Anos ou mais , Seguimentos , Humanos , Estudos Prospectivos
18.
Acta Otorrinolaringol Esp ; 55(10): 463-9, 2004 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-15658555

RESUMO

OBJECTIVES: Detection of antichoclear antibodies in patients with sudden deafness (SD) ranges from five to forty one percent depending on authors. We tried to correlate the level of antibodies measured by Western-blot (WB) and hearing loss. PATIENTS AND METHODS: Forty nine subjects bearing of SD and a positive WB for bovine cochlear antigen. Hearing loss average was measured at the onset and after treatment with deflazacort 1 mg/kg per day by means of audiometry, and antibody titles were quantified in the diluted sera. RESULTS: Initial loss was 49.4+/-20.6%, and after corticotherapy it was 15.9+/-18.0%. There was no statistically significative correlation titles-hearing loss (y=0.1122x+30.613; R2=0.7552) nor titles-recovery (y=-0.0818x+8.,65; R2=0.3229). CONCLUSIONS: Although predictive capability for treatment response is accepted for WB, quantifying of the antibody titles in patients with SD does not allow to make a prognosis about the average hearing recovery.


Assuntos
Autoanticorpos/sangue , Cóclea/imunologia , Glucocorticoides/uso terapêutico , Perda Auditiva Súbita/sangue , Perda Auditiva Súbita/tratamento farmacológico , Metilprednisolona/uso terapêutico , Adulto , Western Blotting , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Indução de Remissão
19.
Acta Otorrinolaringol Esp ; 54(4): 299-302, 2003 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-12825246

RESUMO

We report the case of a seven year-old boy bearing of exudative acute tonsillitis after strawberry ingestion with no previous infectious history. After having diagnosed it as hypersensitivity type I, this patient began to suffer repetitive episodes of exudative and purulent tonsillitis, related to cool drinks and direct manipulation of tonsils. These were hyperplastic and Staphylococcus sp. and Streptococcus sp. were isolated in them. The episodes were shortened by the use of corticosteroids. Tonsillectomy was the definitive therapy. Biopsy informed of mast cells infiltration in germinal centers of both palatine tonsils.


Assuntos
Mastócitos/patologia , Rinite Alérgica Perene/complicações , Tonsilite/etiologia , Tonsilite/patologia , Biópsia , Criança , Humanos , Masculino , Infecções Estafilocócicas/microbiologia , Infecções Estreptocócicas/microbiologia , Tonsilite/microbiologia
20.
Acta Otorrinolaringol Esp ; 54(3): 233-5, 2003 Mar.
Artigo em Espanhol | MEDLINE | ID: mdl-12825347

RESUMO

We report the case of a 29 year-old male with of hereditary spherocytosis, who developed two episodes of sensorineural hearing loss in his right ear after splenectomy due to repetitive hemolytic crisis. We discuss the eventual altiopathogenic mechanism of this audiological disorder.


Assuntos
Perda Auditiva Súbita/etiologia , Complicações Pós-Operatórias , Esferocitose Hereditária/cirurgia , Adulto , Humanos , Masculino
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