[Myocardial infarction in colon cancer].

Paraneoplastic syndromes have a variety of clinical manifestations most frequently resembling systemic diseases and phlebothrombosis. Also, hypercoagulative paraneoplasic syndrome may have some clinical features of myocardial infarction which makes difficult nosological diagnostics.

[Combined low-dose antihypertensive therapy in pregnant women with hypertension and preeclampsia].

The effect of low-dose combination antihypertensive therapy in fixed form, containing 2.5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide, the clinical condition, the daily profile of blood pressure, body adrenoreactivity structural and functional parameters of the left ventricle in 28 pregnant women with preeclampsia in the background chronic hypertension (hypertension stage II, 2 nd degree) and 28 pregnant women with preeclampsia and mild to moderate severity in terms of 22-28 weeks of pregnancy. After 16 weeks of receiving a fixed form, containing 2.5 mg of bisoprolol and 6.25 mg hydrochlorothiazide, the target BP level reached 76% of pregnant women with preeclampsia with chronic hypertension and 81% - with preeclampsia. In both groups, the parameters are optimized daily profile of blood pressure, the value of the total peripheral vascular resistance.

[Hypertensive disease and metabolic syndrome: application of metoprolol].

The aim of this work was to study effects of metoprolol on structural and functional characteristics of left ventricle (LV), cerebral circulation (CC), microcirculation (MC), lipid spectrum, rheologic and viscous properties of blood in patients with grade II-III hypertensive disease (HD) and metabolic syndrome. 65 patients in this condition (ESH/ESC, 2007) were given metoprolol (100-150 mg/d) and indapamide (1.5 mg/d) for 6 months. Daily AP profile, structural and functional characteristics of left ventricle were evaluated before and after therapy by echocardiography, cerebral dopplerography, conjunctival biomicroscopy, measurement of MC, hemorheologic parameters, blood lipid spectrum and glucose level. The target AP level and normalization of AP daily profile were achieved in 65% of the patients. The treatment improved myocardial contractility and diastolic function, decreased LV mass, corrected autoregulation of cerebral blood flow and MC. Metoprolol was shown to be metabolically inert. The study confirmed benefits of its application to the treatment of HD with metabolic syndrome.

[Effect of eprosartan on microcirculation and blood rheology in patients with hypertensive disease]. / Vliianie éprosartana na mikrotsirkuliatsiiu i reologiiu krovi u bol'nykh gipertonicheskoi bolezn'iu.

The use of eprosartan (600-1200 mg/day for 4 weeks) in 28 patients with stage II hypertensive disease was associated with improvement of parameters of microcirculation and blood rheology.

[Lisinopril effects on cerebral blood flow and blood rheology in hypertensive patients]. / Vliianie lizinoprila na mozgovoi krovotok i reologicheskie svoistva krovi u bol'nykh arterial'noi gipertoniei.

AIM: To access the effect of lisinopril (diroton) on cerebral circulation and blood rheology in patients with arterial hypertension stage II. MATERIAL AND METHODS: The trial included 37 patients (16 males, 21 females) with a mean arterial hypertension (AH) history 15.9 +/- 5.6 years. Diroton was given in a dose 10-40 mg/day for 6 months. Cerebral circulation (total cerebral circulation and venous outflow--TCC and VOF) was accessed by means of doppler ultrasonography. Blood and plasm rheology was determined using a rotational viscozymeter ACP-2. Instrumental tests were performed at baseline and at the end of the study. RESULTS: Rheology tests showed that diroton-treated patients achieved a significant decrease in blood viscosity in high, moderate and low shear stress and plasma viscosity, a decrease in platelet aggregation index and an increase in the index of erythrocytic deformability. All these changes were accompanied with a significant fall in fibrinogen and hematocrit. Doppler ultrasound revealed an insignificant increase in TCC and VOF. CONCLUSION: Diroton significantly improved impaired blood rheology and viscosity in AH patients as well as cerebral hemodynamics in patients with subnormal cerebral circulation and venous outflow at baseline.

[The state of hemodynamics and microcirculation in patients with hypertensive disease during long term controlled therapy with lisinopril]. / Sostoianie gemodinamiki i mikrotsirkuliatsii u bol'nykh gipertonicheskoi bolezn'iu pri dlitel'nom kontroliruemom lechenii lizinoprilom.

Lisinopril (Diroton, 10-40 mg/day) was given for 6 months to 30 patients (mean age 57.2+/-0.64 years) with stage II hypertension (WHO, 1999). Left ventricular diastolic function and microcirculation were assessed by echocardiography and biomicroscopy, respectively. Treatment with lisinopril was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart. Parameters of microcirculatory vascular bed also improved.

[Effect of eprosartan on left ventricular diastolic function and cerebral hemodynamics in patients with hypertension]. / Vliianie éprosartana na diastolicheskuiu funktsiiu i tserebral'nuiu gemodinamiku u bol'nykh gipertonicheskoi bolezn'iu.

Eprosartan (600-1200 mg/day) was given for 4 weeks to 28 patients aged 32-62 years with stage II-III hypertension (WHO, 1999). Left ventricular diastolic function and cerebral blood flow were assessed by echocardiography and ultrasound dopplerography. Treatment with eprosartan was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart, venous outflow from cerebral vessels, and restoration of unpaired autoregulation of cerebral blood flow. All these phenomena could potentially lead to normalization of cerebral tissue perfusion and stabilization of cerebral blood flow.

[Use of a "dry" immersion method in the treatment of hypertensive crisis]. / Primenenie metoda "sukhoi" immersii v lechenii gipertonicheskogo kriza.

The effect of so-called dry immersion on hypertensive patients during hypertensive crisis was investigated. It was demonstrated that after 90-minute immersion blood pressure fell due to beneficial hemodynamic and hormonal changes. This therapeutic method produced a sedative and diuretic effect. The above method of non-drug therapy proves highly effective in the treatment of hypertensive crises of different types, produced no side effects and can be used in a hospital as a cost-effective procedure.

[Elimination of hypertensive crisis by means of water-immersion hypodynamia]. / Kupirovanie gipertonicheskogo kriza s pomoshch'iu vodno-immersionnoi gipodinamii.

A new method, "dry" therapeutic immersion, was used to treat hypertonic crisis in 26 patients suffering from stage II essential hypertension. The method turned out effective in removal of crisis both with hyperkinetic and hypo- and eukinetic types of hemodynamics. The use of "dry" therapeutic immersion gave rise to the sedative and diuretic effects. The given non-chemotherapeutic method was found to produce no side effects.