Onset of Work-Life Conflict Increases Risk of Subsequent Psychological Distress in the Norwegian Working Population.

We aimed to assess whether the onset of work-life conflict is associated with a risk of subsequent onset of psychological distress. Respondents from a randomly drawn cohort of the general Norwegian working population were interviewed in 2009 (T1), 2013 (T2), and 2016 (T3) (gross sample n = 13,803). Participants reporting frequent work-life conflict at T1 and/or psychological distress (five-item Hopkins Symptom Checklist mean score ≥ 2) at T2 were excluded to establish a design that allowed us to study the effect of the onset of work-life conflict at T2 on psychological distress at T3. Logistic regression analysis showed that the onset of frequent work-life conflict more than doubled the risk of the onset of psychological distress at T3 (OR = 2.55; 95% CI 1.44-4.51). The analysis of the association between occasional work-life conflict and psychological distress was not conclusive (OR = 1.21; 95% CI 0.77-1.90). No differential effects of sex were observed (log likelihood ratio = 483.7, p = 0.92). The calculated population attributable risk (PAR) suggests that 12.3% (95% CI 2.84-22.9%) of psychological distress onset could be attributed to frequent work-life conflict. In conclusion, our results suggest that the onset of frequent work-life conflict has a direct effect on the future risk of developing symptoms of psychological distress in both male and female workers.

Shift in Food Intake and Changes in Metabolic Regulation and Gene Expression during Simulated Night-Shift Work: A Rat Model.

Night-shift work is linked to a shift in food intake toward the normal sleeping period, and to metabolic disturbance. We applied a rat model of night-shift work to assess the immediate effects of such a shift in food intake on metabolism. Male Wistar rats were subjected to 8 h of forced activity during their rest (ZT2-10) or active (ZT14-22) phase. Food intake, body weight, and body temperature were monitored across four work days and eight recovery days. Food intake gradually shifted toward rest-work hours, stabilizing on work day three. A subgroup of animals was euthanized after the third work session for analysis of metabolic gene expression in the liver by real-time polymerase chain reaction (PCR). Results show that work in the rest phase shifted food intake to rest-work hours. Moreover, liver genes related to energy storage and insulin metabolism were upregulated, and genes related to energy breakdown were downregulated compared to non-working time-matched controls. Both working groups lost weight during the protocol and regained weight during recovery, but animals that worked in the rest phase did not fully recover, even after eight days of recovery. In conclusion, three to four days of work in the rest phase is sufficient to induce disruption of several metabolic parameters, which requires more than eight days for full recovery.