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Biol Trace Elem Res ; 153(1-3): 309-18, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23640280

RESUMO

This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a control diet, control diets containing 1.6 or 5.0 % GOS, a DFL diet and DFL diets containing 1.6 or 5.0 % GOS for 9 days. From day 5 of the feeding period, half of the rats fed with control diets were subcutaneously administered with saline, whereas the remaining rats were administered with PPI for 5 days. Calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe) and zinc (Zn) balances were determined from days 6 to 9. PPI administration significantly decreased the apparent absorption of Ca and Fe and increased urinary P excretion, resulting in decreased Ca, Fe and P retention. GOS dose-dependently increased the apparent absorption of Ca, Mg and Fe and urinary Mg excretion and decreased urinary P excretion. DFL significantly increased the apparent absorption of Ca and Mg and urinary Mg excretion. The combination of DFL and GOS additively affected these parameters, resulting in increased Ca, P and Fe retention, and it further increased the apparent absorption and retention of Zn at 5.0 % GOS. In conclusion, the combination of DFL and GOS improves Ca, P and Fe retention in an additive manner and increases the Zn retention in growing rats with hypochlorhydria induced by PPI.


Assuntos
Acloridria/tratamento farmacológico , Laticínios , Fermentação , Lactobacillus/metabolismo , Oligossacarídeos/metabolismo , Inibidores da Bomba de Prótons/efeitos adversos , Acloridria/induzido quimicamente , Animais , Densidade Óssea , Masculino , Inibidores da Bomba de Prótons/uso terapêutico , Ratos , Ratos Sprague-Dawley , Tomografia Computadorizada por Raios X
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