A New Objective Radiographic Criteria for Diagnosis of Adult Idiopathic Scoliosis: Apical Pedicle Diameter Asymmetry.

OBJECTIVE: We sought to test the hypothesis that a difference of ≥1 mm in pedicle diameter between the convex and concave pedicles at the apex of a lumbar curve is a sensitive and/or specific criteria for adult idiopathic scoliosis (AdIS). METHODS: Thirty-nine operative patients with adult deformity and lumbar major curves were identified. A chart review was performed. Radiographic measurements included lumbar Cobb, curve apex, and Cobb levels involved. Apical pedicle diameter at the concavity and convexity of the curve apex were measured. RESULTS: Among these 39 patients, the average Cobb angle was 48.3 degrees. Curve apex averaged at L1/2 (range L1-L3). The curves spanned 4.7 levels (range 3-7). Twenty-five curves had the apex to the left, while 14 had the apex to the right. The average pedicle diameter at the apex was 6.1 mm. Fourteen patients had apical pedicle diameter asymmetry (APDA) >1 mm. Most (7 of 8, or 87.5%) of the patients with a history of adult idiopathic scoliosis had APDA >1 mm. A minority (7 of 31, 22.5%) of patients without known history of adult idiopathic scoliosis had APDA >1 mm (P < 0.01). CONCLUSIONS: Apical pedicle diameter asymmetry is among the sensitive diagnostic criteria for AdIS and may be useful for differentiating lumbar major AdIS from degenerative lumbar scoliosis. The sensitivity of APDA >1 mm is 87.5%, with specificity of 77.4%. We propose a new, sensitive radiographic criterion for adult idiopathic scoliosis. A difference of ≥1 mm in pedicle diameter between the convex and concave pedicles at that apex of a lumbar curve has a sensitivity of 87.5% and specificity of 77.4% for patient-reported history of adolescent scoliosis. It can be a useful tool as exclusion criteria for studies on AdIS.

Intraoperative versus postoperative radiographic coronal balance for adult spinal deformity surgery.

BACKGROUND: Coronal malalignment in adult spinal deformity (ASD) has a close relationship with patient clinical outcomes. The purpose of this study is to evaluate the relationship between intra- and postoperative coronal radiographic parameters. A novel parameter, the central sacral pelvic line (CSPL), and its relation to the central sacral vertical line (CSVL) is explored. CSPL is a measure of spinal alignment referenced to the patient's pelvis as an intraoperative proxy for CSVL. CSVL is difficult to measure intraoperatively, because a C7-plumb line (referenced to gravity) cannot be drawn in the supine position. METHODS: 47 subjects ≥ 18 years old undergoing a spinal fusion of ≥ 6 levels from 2015 to 2017 were enrolled. The CSPL is defined as the perpendicular line bisecting the midpoint of the line that connects the superior aspects of the acetabuli. Two metrics describing coronal alignment were derived from each radiograph: (1) horizontal distance between the C7-plumb line and the CSPL at C7 (C7-CSPL) and (2) horizontal distance between the C7-plumb line and CSVL (C7-CSVL). Pearson's correlation and linear regression analysis was used to study the relationship between the intraoperative C7-CSPL and the postoperative C7-CSVL. RESULTS: On average, the intraoperative C7-CSPL distance was 32.1 mm, postoperative C7-CSPL 20.8 mm, and postoperative C7-CSVL 18.9 mm. 15/47 (32%) had intraoperative C7-CSPL measurements > 4 cm, requiring intraoperative correction. Of those 15, 10 patients (67%) still had a postoperative C7-CSVL < 4 cm. Linear regression modeling indicates that when intraoperative CSPL is < 7.7 cm on average, the postoperative C7-CSVL will < 4 cm-our threshold for adequate coronal alignment. Patients with intraoperative C7-CSPL > 5 cm had a 50% chance of having a postoperative C7-CSVL > 4 cm; patients with intraoperative C7-CSPL < 5 cm had a 3% chance of having coronal malalignment. There is a strong positive relationship between postoperative C7-CSPL and C7-CSVL (r = 0.80 and 0.85, respectively). CONCLUSION: In adult spinal surgery, the intraoperative coronal alignment measured using the novel C7-CSPL distance correlates well with postoperative C7-CSVL distance. This gives the surgeon an objective measurement of the correction they need after assessing initial intraoperative imaging. Our findings suggest an intraoperative C7-CSPL distance < 5 cm as a threshold value to predict postoperative C7-CSVL < 4 cm in 97% of patients tested.

Effects of tibiofemoral compression on ACL forces and knee kinematics under combined knee loads.

Injuries to the anterior cruciate ligament (ACL) can occur during landing from a jump or changing direction during a cutting maneuver. In these instances, the knee is subjected to combined forces and moments as it flexes under tibiofemoral compression force (TCF). We hypothesized that TCF would increase ACL forces and tibiofemoral motions under isolated and combined modes of loading relevant to knee injury. ACL force and knee kinematics were recorded in human cadaveric specimens during knee flexion from 0° to 50° under the following test conditions (alone and in combination): 2 N-m internal tibial torque (IT), 5 N-m valgus moment (VM), and 45N anterior tibial force (AF). Knees were tested with 25N (baseline), 250N, and 500N TCF. ACL force increased with knee flexion during all tests. As the knee was flexed, VM produced a coupled internal tibial rotation, and IT produced a coupled valgus rotation. ACL forces with IT + VM were significantly higher than with IT alone (beyond 10° flexion) or VM alone (at all flexion angles). Increasing the level of TCF above baseline did not significantly change valgus or tibial rotations for any loading condition, but did significantly increase anterior tibial translation (ATT) at all flexion angles and ACL force at flexion angles beyond 5° to 15°. Addition of AF to tests with IT + VM significantly increased ATT and ACL force without significantly altering internal and valgus rotations. The mechanism of high ACL force generation from increased TCF was related to ATT and not internal or valgus rotations of the tibia. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Reproducibility of choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines.

The purpose of this study was to investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography instruments, namely: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), and Optovue RTVue (Optovue Inc., Fremont, CA). This cross-sectional non-interventional study was performed in a single institution. Images were obtained in 47 eyes of 47 healthy volunteers which age ranged between 23 and 72 without ocular pathology. All subjects were imaged on the fovea using Cirrus HD 1-line raster, Spectralis enhanced depth imaging, and RTVue retina-cross. The choroid was measured subfoveally and at intervals of 500 µm from the fovea nasally and temporally up to 2500 µm. Paired t test, modified Bland-Altman plot, and Pearson's correlation were used to compare the results. There is no significant difference between the systems for any measurement within 2500 µm either side of the fovea for most points. Inter-observer correlation was strong for RTVue, and moderate in both Cirrus and Spectralis.