Amoxicillin degradation by iron photonanocatalyst synthetized by green route using pumpkin (Tetsukabuto) peel extract.

Amoxicillin is a pharmaceutical compound that is not degraded in wastewater treatment plants, causing harm to the environment. In this work, an iron nanoparticle (IPP) was synthesized using pumpkin (Tetsukabuto) peel extract for the degradation of amoxicillin under UV light. The IPP was characterized using scanning electron microscopy/energy dispersive x-ray spectroscopy, transmission electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, and Raman spectroscopy techniques. The photocatalytic efficiency of IPP was analyzed by investigating the effect of IPP dosage (1-3 g L-1), initial amoxicillin concentration (10-40 mg L-1), pH (3-9), reaction time (10-60 min), and the effect of inorganic ions (1 g L-1). The optimum conditions for the maximum photodegradation removal (≈60%) were IPP = 2.5 g L-1, initial amoxicillin concentration = 10 mg L-1, pH = 5.6, and irradiation time = 60 min. The results of this study showed that inorganic ions (Mg2+, Zn2+, and Ca2+) negatively affect the photodegradation of amoxicillin by IPP; the quenching test showed that hydroxyl radical (OH•) is the primary reactive species of the reaction; NMR analysis revealed changes in amoxicillin molecules after photoreaction; the subproducts of photodegradation were identified by LC-MS; the proposed kinetic model demonstrated good applicability, predicting the behavior of OH• and determining the kinetic constant, and the cost analysis based on required energy (238.5 kWh m-3 order-1) indicated that the amoxicillin degradation method by IPP is economically viable. This study developed a new efficient iron nanocatalyst for the removal of antibiotics from aqueous environments and provided optimal conditions and relevant information in the area of advanced oxidative processes.

The use of clays for chlorhexidine controlled release as a new perspective for longer durability of dentin adhesion.

The adhesive systems have the function to establish the connection between the restorative material and dental tissue, therefore it is of fundamental importance, because failures in the adhesive interface can reduce the life of a dental restoration. This study investigated the possibility of using the adhesive layer as a chlorhexidine modified release system evaluating their impact on the properties of these systems as well as evaluating the impact of these systems on immediate and post-aging dentin adhesion. Were used a matrix with BisGMA, UDMA, HEMA and TEGDMA copolymer and clay particles (Dellite 67G); associated with a chlorhexidine and a camphorquinone photoinitiator system. The properties of these systems were evaluated by the XRD, FTIR spectrophotometer, flexural strength, elasticity modulus, drug release, enzymatic inhibition and dentin adhesion resistance. The presence of the clay can raise the mechanical properties of the adhesive systems engendering a more resistant hybrid layer and led to a more sustained release of chlorhexidine in the systems, allowing a longer effective period of MMP-2 inhibition. The hypothesis that the addition of clays as release modulators could increase the effectiveness of these drugs in inhibiting the dentin's MPPs and consequently enhancing the adhesive durability was confirmed. These results indicate that the controlled release of chlorhexidine is able to reduce the process of loss of adhesion presenting itself as a promising system to increase the longevity of dental restorations.