Q-Rank: Reinforcement Learning for Recommending Algorithms to Predict Drug Sensitivity to Cancer Therapy.

In personalized medicine, a challenging task is to identify the most effective treatment for a patient. In oncology, several computational models have been developed to predict the response of drugs to therapy. However, the performance of these models depends on multiple factors. This paper presents a new approach, called Q-Rank, to predict the sensitivity of cell lines to anti-cancer drugs. Q-Rank integrates different prediction algorithms and identifies a suitable algorithm for a given application. Q-Rank is based on reinforcement learning methods to rank prediction algorithms on the basis of relevant features (e.g., omics characterization). The best-ranked algorithm is recommended and used to predict the response of drugs to therapy. Our experimental results indicate that Q-Rank outperforms the integrated models in predicting the sensitivity of cell lines to different drugs.

CEP4HFP: Complex Event Processing for Heart Failure Prediction.

This paper presents a novel health analysis approach for heart failure prediction. It is based on the use of complex event processing (CEP) technology, combined with statistical approaches. A CEP engine processes incoming health data by executing threshold-based analysis rules. Instead of having to manually set up thresholds, our novel statistical algorithm automatically computes and updates thresholds according to recorded historical data. Experimental results demonstrate the merits of our approach in terms of speed, precision, and recall.