East Antarctic warming forced by ice loss during the Last Interglacial.

During the Last Interglacial (LIG; 129-116 thousand years before present), the Antarctic ice sheet (AIS) was 1 to 7 m sea level equivalent smaller than at pre-industrial. Here, we assess the climatic impact of partial AIS melting at the LIG by forcing a coupled climate model with a smaller AIS and the equivalent meltwater input around the Antarctic coast. We find that changes in surface elevation induce surface warming over East Antarctica of 2 to 4 °C, and sea surface temperature (SST) increases in the Weddell and Ross Seas by up to 2 °C. Meltwater forcing causes a high latitude SST decrease and a subsurface (100-500 m) ocean temperature increase by up to 2 °C in the Ross Sea. Our results suggest that the combination of a smaller AIS and enhanced meltwater input leads to a larger sub-surface warming than meltwater alone and induces further Antarctic warming than each perturbation separately.

Acute air pollution and temperature exposure as independent and joint triggers of spontaneous preterm birth in New South Wales, Australia: a time-to-event analysis.

Introduction: Exposure to high ambient temperatures and air pollution has been shown to increase the risk of spontaneous preterm birth (sPTB). Less clear are the effects of cold and the joint effects of air pollution and temperature. Methods: Using a Cox proportional hazard regression model, we assessed the risk of independent and combined short-term exposure to ambient daily mean temperature and PM2.5 associated with sPTB in the last week before delivery on overall sPTB (weeks 23-36) and three subtypes: extremely sPTB, very sPTB, and moderate-to-late sPTB for a birth cohort of 1,318,570 births from Australia (Jan 2001-Dec 2019), while controlling for chronic exposure (i.e., throughout pregnancy except the last week before delivery) to PM2.5 and temperature. The temperature was modeled as a natural cubic spline, PM2.5 as a linear term, and the interaction effect was estimated using a multiplicative term. For short-term exposure to temperature hazard ratios reported are relative to the median temperature (18.1°C). Results: Hazard ratios at low temperature [5th percentile(11.5°C)] were 0.95 (95% CI: 0.90, 1.00), 1.08 (95% CI: 0.84, 1.4), 0.87 (95% CI: 0.71, 1.06), and 1.00 (95% CI: 0.94, 1.06) and greater for high temperature [95th percentile (24.5°C)]: 1.22 (95% CI: 1.16, 1.28), 1.27 (95% CI: 1.03, 1.57), and 1.26 (95% CI: 1.05, 1.5) and 1.05 (1.00, 1.11), respectively, for overall, extremely, very, and moderate-to-late sPTBs. While chronic exposure to PM2.5 had adverse effects on sPTB, short-term exposure to PM2.5 appeared to have a negative association with all types of sPTB, with hazard ratios ranging from 0.86 (95th CI: 0.80, 0.94) to 0.98 (95th CI: 0.97, 1.00) per 5 µg/m3 increase in PM2.5. Discussion: The risk of sPTB was found to increase following acute exposure to hot and cold ambient temperatures. Earlier sPTB subtypes seemed to be the most vulnerable. This study adds to the evidence that short-term exposure to ambient cold and heat and longer term gestational exposure to ambient PM2.5 are associated with an elevated risk of sPTB.

Magnitude of the 8.2 ka event freshwater forcing based on stable isotope modelling and comparison to future Greenland melting.

The northern hemisphere experienced an abrupt cold event ~ 8200 years ago (the 8.2 ka event) that was triggered by the release of meltwater into the Labrador Sea, and resulting in a weakening of the poleward oceanic heat transport. Although this event has been considered a possible analogue for future ocean circulation changes due to the projected Greenland Ice Sheet (GIS) melting, large uncertainties in the amount and rate of freshwater released during the 8.2 ka event make such a comparison difficult. In this study, we compare sea surface temperatures and oxygen isotope ratios from 28 isotope-enabled model simulations with 35 paleoproxy records to constrain the meltwater released during the 8.2 ka event. Our results suggest that a combination of 5.3 m of meltwater in sea level rise equivalent (SLR) released over a thousand years, with a short intensification over ~ 130 years (an additional 2.2 m of equivalent SLR) due to routing of the Canadian river discharge, best reproduces the proxy anomalies. Our estimate is of the same order of magnitude as projected future GIS melting rates under the high emission scenario RCP8.5.

The Australian National Pollutant Inventory Fails to Fulfil Its Legislated Goals.

Publically accessible pollution databases, such as the Australian National Pollutant Inventory, contain information on chemical emissions released by industrial facility and diffuse sources. They are meant to enable public scrutiny of industrial activity, which in turn, is meant to lead to industries reducing their pollution. In Australia, however, concerns have been consistently raised that this process is not occurring. To assess whether Australia's National Pollutant Inventory is fulfilling its legislated goals, we examined the accuracy and consistency of the largest facility and diffuse source of airborne lead, a major pollutant of concern for public health. Our analysis found that the emissions estimates provided by the Inventory were not accurate and were not consistent with other sources of emissions within the Inventory, potentially distorting any user interpretation of emissions estimates provided by the National Pollutant Inventory. We conclude that for at least these important public health pollution sources, the Inventory does not fulfil its legislated goals.

Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions.

The major advantage of hydroxyapatite (HA)-forming calcium phosphate cements (CPCs) used as bone replacement materials is their setting under physiological conditions without the necessity for thermal treatment that allows the incorporation of biological factors. In the present study, we have combined the biocompatible consolidation of CPCs with the potential of rapid prototyping (RP) techniques to generate calcium phosphate-based scaffolds with defined inner and outer morphology. We demonstrate the application of the RP technique three-dimensional (3D) plotting for the fabrication of HA cement scaffolds. This was realized by utilizing a paste-like CPC (P-CPC) which is stable as a malleable paste and whose setting reaction is initiated only after contact with aqueous solutions. The P-CPC showed good processability in the 3D plotting process and allowed the fabrication of stable 3D structures of different geometries with adequate mechanical stability and compressive strength. The cytocompatibility of the plotted P-CPC scaffolds was demonstrated in a cell culture experiment with human mesenchymal stem cells. The mild conditions during 3D plotting and post-processing and the realization of the whole procedure under sterile conditions make this approach highly attractive for fabrication of individualized implants with respect to patient-specific requirements by simultaneous plotting of biological components.

Geochemical proxies of North American freshwater routing during the Younger Dryas cold event.

The Younger Dryas cold interval represents a time when much of the Northern Hemisphere cooled from approximately 12.9 to 11.5 kiloyears B.P. The cause of this event, which has long been viewed as the canonical example of abrupt climate change, was initially attributed to the routing of freshwater to the St. Lawrence River with an attendant reduction in Atlantic meridional overturning circulation. However, this mechanism has recently been questioned because current proxies and dating techniques have been unable to confirm that eastward routing with an increase in freshwater flux occurred during the Younger Dryas. Here we use new geochemical proxies (DeltaMg/Ca, U/Ca, and (87)Sr/(86)Sr) measured in planktonic foraminifera at the mouth of the St. Lawrence estuary as tracers of freshwater sources to further evaluate this question. Our proxies, combined with planktonic delta(18)O(seawater) and delta(13)C, confirm that routing of runoff from western Canada to the St. Lawrence River occurred at the start of the Younger Dryas, with an attendant increase in freshwater flux of 0.06 +/- 0.02 Sverdrup (1 Sverdrup = 10(6) m(3).s(-1)). This base discharge increase is sufficient to have reduced Atlantic meridional overturning circulation and caused the Younger Dryas cold interval. In addition, our data indicate subsequent fluctuations in the freshwater flux to the St. Lawrence River of approximately 0.06-0.12 Sverdrup, thus explaining the variability in the overturning circulation and climate during the Younger Dryas.