RESUMO
The cytokine blood profile in patients with complicated erysipelas was investigated. It was found that in patients with complications of erysipelas (gangrene, phlegmon, abscess, thrombophlebitis of the subcutaneous veins of the shin) levels of pro-inflammatory cytokines IL-1ß, TNF-α, IL-2, IL-6 in serum significantly increase and level of anti-inflammatory cytokine IL-4 increases slightly, as well as was found a significant increase in coefficients reflecting the ratio of pro-inflammatory and anti-inflammatory cytokines, which indicates the prevalence in the blood of examined patients with complications of erysipelas an anti-inflammatory properties. A more significant increase in pro-inflammatory cytokines serum levels is typical for patients with destructive forms of erysipelas - phlegmonous and gangrenous, a slight increase - for patients without purulent-necrotic component of complication (thrombophlebitis of the subcutaneous veins of the shin). In the future we plan to study pharmacological correction of shifts in cytokine blood profile with drugs with immunomodulating properties in patients with complicated erysipelas.
Assuntos
Abscesso/sangue , Celulite (Flegmão)/sangue , Erisipela/sangue , Gangrena/sangue , Tromboflebite/sangue , Abscesso/complicações , Abscesso/tratamento farmacológico , Abscesso/imunologia , Adulto , Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Biomarcadores/sangue , Celulite (Flegmão)/complicações , Celulite (Flegmão)/tratamento farmacológico , Celulite (Flegmão)/imunologia , Erisipela/complicações , Erisipela/tratamento farmacológico , Erisipela/imunologia , Feminino , Gangrena/complicações , Gangrena/tratamento farmacológico , Gangrena/imunologia , Humanos , Interleucina-1beta/sangue , Interleucina-1beta/imunologia , Interleucina-2/sangue , Interleucina-2/imunologia , Interleucina-4/sangue , Interleucina-4/imunologia , Interleucina-6/sangue , Interleucina-6/imunologia , Masculino , Pessoa de Meia-Idade , Tromboflebite/complicações , Tromboflebite/tratamento farmacológico , Tromboflebite/imunologia , Fator de Necrose Tumoral alfa/sangue , Fator de Necrose Tumoral alfa/imunologiaRESUMO
The steps of human spermatozoa treatment for flow cytofluorometric analysis of their DNA content are described in detail. The authors demonstrate the possibility of simultaneous measurement of haploid, pathologically altered, and immature spermatozoa in the ejaculate and estimation of their ratio. The diagnostic value of the method is assessed.
Assuntos
Infertilidade Masculina/patologia , Espermatozoides/citologia , DNA/análise , Citometria de Fluxo/métodos , Humanos , MasculinoAssuntos
Coagulação Sanguínea/efeitos dos fármacos , Doença das Coronárias/sangue , Pré-Medicação , Extração Dentária , Anticoagulantes/uso terapêutico , Humanos , Nitrazepam/uso terapêutico , Extratos Vegetais/uso terapêutico , Plantas Medicinais , Complicações Pós-Operatórias/prevenção & controle , Trombose/prevenção & controle , ValerianaRESUMO
Experiments conducted on dogs with the help of resistography showed chlorpromazine capable of reducing the resistance of the coronary vessels, whereas droperidol and not have any regular effect on the resistance of the cardiac vessels to the blood flow. Both drugs inhibited pressor and depressor reflexes on the coronary vessels reproduced by the stimulation of afferent fibers of the tibial and vagal nerves, as well as the response of the coronary vessels to the administration of epinephrine and norepinephrine.
Assuntos
Clorpromazina/farmacologia , Circulação Coronária/efeitos dos fármacos , Droperidol/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Volume Cardíaco/efeitos dos fármacos , Depressão Química , Cães , Estimulação Elétrica , Epinefrina/farmacologia , Norepinefrina/farmacologia , Reflexo/efeitos dos fármacos , Resistência Vascular/efeitos dos fármacos , Sistema Vasomotor/efeitos dos fármacosRESUMO
In experiments on dogs conducted by means of resistography Curanthil (Dipyridamol) was shown to produce a consistent fall in the resistance to the blood flow in the cardiac vessels due to their active depressor reaction. Besides, Curanthil helps a distinct fall in the resistance of the vessels of the small intestine, sceletal muscles and, to a lower degree, of the brain. These data do not support those of a selective coronary-dilating action of this drug. The reaction of the renal vessels to Curanthil was not uniform and was predominantly of a pressor nature.