1.
Chem Commun (Camb)
; 52(15): 3235-8, 2016 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26812468
RESUMO
Design and synthesis of symmetric mannose-functionalized oligothiophenes is reported. Self-organization of these bolaamphiphiles in solution and in the solid state was investigated by optical and AFM experiments. Fluorescence measurements revealed efficient loading and pH-dependent release of the anti-cancer drug doxorubicin. Delivery and release of the active drug into viable A549 cells as well as chirality-dependent cellular toxicity of the bolaamphiphilic transporter were evident from in vitro experiments.
Assuntos
Antibióticos Antineoplásicos/administração & dosagem , Doxorrubicina/administração & dosagem , Tiofenos/química , Preparações de Ação Retardada , Microscopia de Força Atômica , Espectrometria de Fluorescência , Espectrofotometria Ultravioleta
2.
Angew Chem Int Ed Engl
; 39(19): 3481-3486, 2000 Oct 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11091396
3.
Angew Chem Int Ed Engl
; 39(15): 2679-2684, 2000 Aug 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10934393