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1.
J Nucl Med ; 27(7): 1138-42, 1986 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-3723189

RESUMO

Iodine-123-4-amino-3-iodobenzylguanidine ([123I]AIBG), an analog of 123I metaiodobenzylguanidine ([123I]MIBG), has an advantage in having a more rapid and simple synthesis. This, combined with animal data that suggested a greater affinity of the new radiopharmaceutical for the autonomic innervation of the myocardium led us to study the biodistribution of [123I]AIBG in three men with metastatic pheochromocytoma. In all instances, [123I]AIBG revealed the same metastatic deposits shown by [123I]MIBG. Iodine-123 AIBG uptake, however, was greater than [123I]MIBG in lung, gut, and spleen. These higher backgrounds may pose diagnostic problems in some cases.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Radioisótopos do Iodo , Iodobenzenos , Feocromocitoma/secundário , 3-Iodobenzilguanidina , Adulto , Humanos , Iodobenzenos/metabolismo , Masculino , Pessoa de Meia-Idade , Feocromocitoma/diagnóstico por imagem , Cintilografia , Distribuição Tecidual
2.
Radiology ; 155(3): 789-92, 1985 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-4001380

RESUMO

The radiopharmaceutical iodine 131 metaiodobenzylguanidine (I-131 MIBG) has been shown to locate pheochromocytomas scintigraphically with a false-negative rate of approximately 13%. To improve image quality and reduce the false-negative rate, I-123 was examined as a radioactive label for MIBG, as it has many advantages over I-131, including superior dosimetry and better detection efficiency. Diagnostic doses of 0.5 mCi (18.5 MBq) I-131 MIBG and 10.0 mCi (370.0 MBq) I-123 MIBG with nearly equivalent radiation dosimetries were compared in 18 patients with known or suspected pheochromocytomas. Images of superior quality were obtained with I-123 MIBG in 18 of 18 patients, and in eight cases lesions not visualized on I-131 MIBG scintigraphy were portrayed. A further advantage of I-123 MIBG is that it permits single photon emission computed tomography (SPECT). This was performed in six cases and provided additional information in three cases. The adrenal medullae were definitely visualized using I-123 scintigraphy in eight of 14 patients still possessing adrenal glands, whereas I-131 MIBG images portrayed the adrenal medulla in only one of 14 cases. Five remaining patients had multiple abdominal tumor deposits that were difficult to differentiate from normal adrenal medullae.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Iodobenzenos , Feocromocitoma/diagnóstico por imagem , 3-Iodobenzilguanidina , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cintilografia , Tomografia Computadorizada por Raios X
3.
J Nucl Med ; 25(4): 436-40, 1984 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-6544815

RESUMO

The radiopharmaceutical m-[131I]iodobenzylguanidine (I-131 MIBG), which is readily taken up by adrenergic vesicles, produces scintigraphic images of pheochromocytomas in man but rarely visualizes normal adrenal glands. Iodine-123 has many potential advantages over I-131 as a radiolabel for MIBG, including shorter half-life, freedom from beta emissions, and increased gamma-camera efficiency. In this study, diagnostic doses of MIBG labeled with I-131 and I-123, with nearly equivalent radiation dosimetry, were compared as imaging agents in eight patients with known or suspected pheochromocytoma. Images of superior quality were obtained with I-123 MIBG, and lesions not visualized using I-131 MIBG were portrayed. In addition, the normal adrenal medullae were visualized on the I-123 MIBG scintigrams in six out of eight patients.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Medula Suprarrenal/diagnóstico por imagem , Radioisótopos do Iodo , Iodobenzenos , Feocromocitoma/diagnóstico por imagem , 3-Iodobenzilguanidina , Adolescente , Adulto , Criança , Feminino , Humanos , Hipertensão/diagnóstico por imagem , Masculino , Feocromocitoma/secundário , Cintilografia
4.
Clin Nucl Med ; 8(10): 465-8, 1983 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-6653001

RESUMO

A technique is presented for the bedside performance of radionuclide cisternography in the preterm neonate. Using a portable gamma camera, with a low energy, converging collimator, high quality diagnostic images were obtained in 31 infants, following the lumbar subarachnoid injection of 100 micro Ci In-111 DTPA. The technique is safe, and provides valuable information about CSF dynamics unavailable by any other method.


Assuntos
Hidrocefalia/diagnóstico por imagem , Índio , Doenças do Prematuro/diagnóstico por imagem , Ácido Pentético , Radioisótopos , Humanos , Hidrocefalia/líquido cefalorraquidiano , Recém-Nascido , Doenças do Prematuro/líquido cefalorraquidiano , Cintilografia/instrumentação
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