Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Nat Prod Res ; 33(23): 3398-3403, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29888963

RESUMO

Two new phenolic glycoside compounds (1, 2) and ten known analogues (3-12) have been isolated from the ethanolic extract of Brassica rapa flowers and identified as 2-O-ß-d-glucopyranosyl-(1S)-(4-methoxyphenyl)ethylene glycol (1), 2-(4-O-ß-d-allopyranosyl)phenyl-ethanol (2), 2-O-ß-d-glucopyranosyl-(1S)-phenylethylene glycol (3), 2-O-ß-d-glucopyranosyl-(1R)-phenylethylene glycol (4), (Z)-p-coumaryl-O-ß-d-glucopyranoside (5), phenyl-O-ß-d-glucopyranoside (6), 2-phenylethyl-O-ß-d-glucopyranoside (7), salidroside (8), 2-(2-hydroxyphenyl)ethanol-O-ß-d-glucopyranoside (9), 4-methoxybenzyl-O-ß-d-glucopyranoside (10), 2,4,6-trimethoxyphenyl-1-O-ß-d-glucopyranoside (11) and sachaliside 1 (12). The structures of 1 and 2, including absolute configurations, were determined by spectroscopic data (1H NMR, 13C NMR, HSQC, HMBC and ORD) and chemical methods. In addition, most of them exhibited inhibitory activity with IC50 values ranging from 14.43 to 50.20 µM in comparison to the positive control acarbose (IC50 = 15.76 µM) in intestinal α-glucosidase inhibitory activity tests.


Assuntos
Brassica rapa/química , Inibidores de Glicosídeo Hidrolases/química , Inibidores de Glicosídeo Hidrolases/farmacologia , Fenóis/química , Fenóis/farmacologia , Avaliação Pré-Clínica de Medicamentos , Flores/química , Glucosídeos/química , Glucosídeos/farmacologia , Glicosídeos/química , Glicosídeos/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Extratos Vegetais/química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA