[Tardive neuroleptic-induced dyskinesias]. / Pozdnie (tardivnye) neiroleptik-indutsirovannye diskinezii.

Drugs that block dopaminergic transmission are currently widely used in the treatment of psychiatric diseases. One of the significant, common complications of therapy are tardive dyskinesias, which develop after prolonged, at least 3 months, therapy with antipsychotics and significantly reduce the quality of life of patients. Tardive dyskinesia is an extrapyramidal disorder, mainly manifested by involuntary hyperkinesis of the muscles of the face and tongue. These movements negatively affect the patient's daily activities and quality of life. This article reviews the currently available treatment strategies for this type of disorder. One of the promising methods is therapy with Normokinesin (tetrabenazine), which, by reducing dopaminergic stimulation of brain neurons, significantly reduces hyperkinesis.

[Results from application of a portal vein ligature at surgical treatment of primarily unresectable colorectal liver metastases].

Introduction: Selected patients with unresectable colorectal liver metastases (CRLM) may become resectable using a two-step approach with portal vein ligature (PVL). The purpose of this study is the evaluation of the results of the tow-staged liver resection (LR) using PVL for CRLM in our clinic. Material and Methods: During the period 2005-2015 year at the Clinic of hepatobiliary and transplant surgery, MMA-Sofia 290 curative LR for CRL were carried out. In 17 (5.9%) of them is used a two-stage approach with an initial PVL. Results: The reasons for unresectability were multinodularity of the disease in 70.6%, the size of LM (11.8%), poor location (17.6%). Synchronous LM was at 94% of the cases. Simultaneous resection of the primary tumor at the first operation carried out in 58.8% of the cases. During the second operation, at 94% of patients require a major LR. Patients completed a two-staged approach median survival was 40.43 m., with a found that extended right hemihepatectomy adversely affect survival in patients with two-stage hepatectomy (p=0.023), increasing the risk over 6 times. Conclusion: The multidisciplinary approach is the most precise form, ensuring proper selection and behavior in patients under consideration for two-stage approach to optimize the therapeutic behavior and clinical outcomes.

AN APPROACH TO THE DETERMINATION OF A PROGNOSTIC INDEX FOR THE SCOPE OF SIMULTANEOUS RESECTION IN PATIENTS WITH SYNCHRONOUS COLORECTAL LIVER METASTASES.

Based on the results of 62 simultaneous operations in patients with synchronous liver metastases from colorectal cancer, an attempt was made to calculate the index, assisting the surgeon in the selection of the liver resection, considering the sensitivity and specificity of the test. The index is calculated using equations based on variables and their coefficients from Cox regression analysis. The type of surgery is associated with prognosis for survival of the operated patients. The results can serve as a basis for further research in this area.

Alpha-galactosidase of the marine bacterium Pseudoalteromonas sp. KMM 701.

An alpha-galactosidase that inactivates the group specificity of B erythrocytes (group III) of human blood and does not affect A erythrocytes (group II) was isolated from the marine bacterium Pseudoalteromonas sp. KMM 701. The enzyme preparation did not contain lectin, hemolytic, sialidase, endoglycanase, or glycosidase activities. The enzyme is stable at 20 degreesC for 24 h, has pH optimum for catalysis within the range of 6.7-7.7, and is stable to high concentrations of NaCl. It is 4-fold more efficient than the alpha-galactosidase from green coffee beans. At pH 7.0 the Km for p-nitrophenyl-alpha-D-galactopyranoside is 0.29 mM. The molecular weight of the enzyme determined by gel-filtration is 195 +/- 5 kD. The alpha-galactosidase is denatured by urea and guanidine hydrochloride. Its activity does not depend on the presence of metal ions. It contains a sulfhydryl group essential for its catalytic activity.

[Mechanism of disruption of histamine metabolism in salivary glands in experimental botulism]. / K mekhanizmu narusheniia obmena gistamina v sliunnoi zheleze pri éksperimental'nom botulizme.

Content of histamine was increased in submaxillary salivary gland of rats in generalized and local forms of botulinic intoxication. Permeability of the histohematic barrier for blood serum proteins was not altered in the salivary gland. Content of histamine was normalized after treatment with pilocarpine. Botulinic intoxication was apparently responsible for short-term and unspecific alterations of histamine content in submaxillary salivary gland.