[Morphological aspects of acute intoxication with azaleptin].

Clinico-anatomical analysis, chemico-toxicological and histological examination of material from 54 deceased from intoxication with azaleptin both in urgent toxicology department and pre-admission stage, were performed. Morphology of intoxication with azaleptin was studied, structural base of genopathy at these intoxications was developed.

[Morphological aspects of diagnosis of acute opiate poisoning]. / Morfologicheskie aspekty diagnostiki ostrykh otravlenii opiatami.

Clinical anatomical analysis, forensic chemical, morphological, bacteriological, and immunological investigations of material from 62 subjects dead from acute poisoning with opiates before hospitalization (31 cases) and in hospital (31 cases) were carried out. Organ and tissue lesions typical of opiate poisoning were detected. The outcome of acute poisoning with opiates is largely determined by severe dystrophic and inflammatory processes in organs and tissues, typical of narcomaniacs.

[Morphological changes in lungs of patients with spinal injuries died in hospital]. / Morfologicheskie izmeneniia v legkikh u lits s travmoi pozvonochnika, umershikh v statsionare.

Morphological characteristics of changes in the spine and lungs in patients with spinal injuries dead in hospital are described. Spinal edemas were detected in all cases. Edemas were found even in subjects dead at the place where the injury was inflicted. Morphological changes in the lungs were characterized by a phase-wise process, depended on the volume of injury, duration of hospitalization, medical care rendered, and manifested by disorders of blood content of the organ, development of tissue edema, and pneumonia. These data do not rule out the development of pneumonia in patients with spinal injuries.

[Morphologic changes in spinal cord of patients with spinal injuries who died in hospital]. / Morfologicheskie izmeneniia spinnogo mozga u lits s travmoi pozvonochnika, umershikh v statsionare.

Morphologic changes in the spine have been investigated in patients with spinal injuries who died in hospital. The incidence of injuries has been evaluated as 9.3% of mechanical injuries. Purposeful search for possible injuries increased the rate of detection of injuries of the spine and the cord. Spinal cord can be impaired without involving the osseous formations and spinal ligaments. Edema of the cord tissue develops during the early period of injury and prevents the detection of injuries, persisting for a long time after the injury. Edemas are detected even in subjects who died at the site of accident.

[Pathologic anatomy of traumatic shock during peace time]. / Patologicheskaia anatomiia travmaticheskogo shoka mirnogo vremeni.

The study on the morphology of organs in 316 fatalities due to traumatic shock and blood loss and organs of 120 dogs and 25 rats sacrificed after reproduction of closed trauma of the chest accompanied by blood loss revealed the dependence of morphological changes on the time of shock development and the size of blood loss. Soon after trauma, disorders in the permeability of the capillary basal membrane are found against the background of massive blood loss. Disorders in hemodynamics progress during the first 24 hours when first signs of necrobiosis of the parenchymatous organs begin to appear. Circulatory disorders in the myocardium, brain, and lungs regularly found in this period aggravate the progress of hypoxia and dystrophic changes which are clearly seen in the next 2-4 days. Inadequate treatment in the first days after trauma may increase microcirculatory disorders and necrotic processes sometimes progressing in some organ to its insufficiency, more frequently observed in the lungs or heart (myocardial infarction). The dependence of the above-mentioned complications on the initial manifestations of traumatic shock combined with massive blood loss allowed them to be united into a traumatic disease described in separate phases of its development.