[Trends in endovascular treatment and prevention of portal bleeding]. / Tendentsii v rentgenendovaskulyarnom lechenii i profilaktike portal'nykh krovotechenii (obzor literatury).

Bleeding from esophageal and gastric varices is a major factor of mortality in patients with portal hypertension. The gold standard for diagnosis of portal hypertension is hepatic venous pressure gradient determining the treatment algorithms and risk of recurrent bleeding. Combination of endoscopic methods and therapy is limited by varix localization and not always effective. In these cases, endovascular bypass and decoupling techniques are preferred. Early endovascular treatment of portal bleeding is effective for hemostasis and higher transplantation-free survival of patients. Early transjugular intrahepatic portosystemic bypass should be associated with 8-mm covered stents of controlled dilation. Combination of endovascular techniques reduces the complications of each technique and potentiates their positive effect. Endovascular treatment and prevention of portal bleeding should be determined by anatomical features of portal venous system.

[Influence of early surgery and endoscopic interventions on the risk of infection in patients with pancreatic necrosis]. / Vliyanie rannikh operativnykh i endoskopicheskikh vmeshatel'stv na risk infitsirovaniya u patsientov s pankreonekrozom.

OBJECTIVE: To prevent purulent-septic complications in patients with destructive pancreatitis. MATERIAL AND METHODS: A cohort study included 488 patients with pancreatic necrosis: group 1 (n=331) - active surgical strategy, group 2 (n=157) - follow-up and therapy. We used binary logistic regression to predict purulent-septic complications. RESULTS: Original model of independent variables significantly (p<0.001) revealed 5.3 times higher risk of infectious complications after laparotomy within the first week after hospitalization. Incidence of these events increased by 2.8 times in patients biliary pancreatitis compared to alcohol-alimentary pancreatitis. Complication rate was higher in older patients (by 2.1% for each year). Risk of purulent-septic complications decreased by 57.4% in women compared to men. There was no significant correlation between risk of infectious complications and endoscopic procedures. Specificity and sensitivity of the model was 74.2 and 72.6%, respectively. CONCLUSION: Original model significantly predicts the risk of purulent-septic complications within the first week after hospitalization. Refusal of early active surgical strategy in these patients will significantly reduce the likelihood of purulent-septic complications.

[Global trends in endovascular treatment of patients with malignant neoplasms and metastatic liver damage]. / Obzor mirovykh tendentsii v interventsionnom rentgenendovaskulyarnom lechenii patsientov so zlokachestvennymi novoobrazovaniyami i metastaticheskim porazheniem pecheni.

OBJECTIVE: To analyze the results of endovascular embolization of malignant tumors and liver metastases. MATERIAL AND METHODS: We analyzed international studies on the treatment of patients with neoplastic liver lesions and complications after regional endovascular embolization following leakage of chemotherapeutic drugs from the target vessel and negative systemic effects. The results of embolization of liver arteries without chemotherapeutic drugs were also analyzed. We reviewed the PubMed, The Cochrane Library, Web of Science databases, as well as Russian scientific and practical journals. CONCLUSION: Literature data indicate high clinical effectiveness of interventional treatment of patients with malignant neoplasms and metastatic liver damage.

[Laparoscopic versus laparoscopy-assisted suturing of perforated peptic ulcers (meta-analysis)]. / Laparoskopicheskoe i laparoskopicheski assistirovannoe ushivanie probodnoi yazvy (metaanaliz).

OBJECTIVE: To compare laparoscopic and laparoscopy-assisted repair of perforated peptic ulcer using evidence-based methods. MATERIAL AND METHODS: A systematic review and meta-analysis were carried out in accordance with the recommendations of the Ministry of Health of Russian Federation and Cochrane Handbook for Systematic Reviews.Data searching was carried out in Russian and English languages using the E-library, Cochrane Library and PubMed databases. We analyzed titles and references in specialized journals and thematic reviews, respectively. Clarifying information was obtained via personal contacts with the heads of surgical hospitals. The RevMan 5.4 software was used for statistical analysis. RESULTS: We found no randomized trials devoted to comparison of laparoscopic and laparoscopy-assisted surgeries in patients with perforated peptic ulcer. Meta-analysis was based on non-randomized trials with satisfactory methodological quality according to the I-ROBINS formalized assessment. Overall clinical material included 478 observations: 229 (47.9%) laparoscopic surgeries and 249 (52.1%) laparoscopy-assisted procedures via minimally invasive access. There were no conversions. Incidence of postoperative complications was 4.36 and 8.83% (OR=0.39, 95% CI 0.08, 1.87), postoperative mortality 0.87 and 0.81%, respectively (OR=1.26, 95% CI 0.08, 8.24). Laparoscopic surgeries were shorter (MD= -8 min, 95% CI -9.7, -6.4). Length of hospital-stay was also shorter after laparoscopic surgery (MD= -4.6, 95% CI -9.7, -6.4). CONCLUSION: Laparoscopic operations are shorter and accompanied by lower incidence of postoperative complications and less hospital-stay. Large statistical power is required to confirm these differences.

[Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis]. / Diagnostika i prognozirovanie pankreatogennoi entsefalopatii u bol'nykh destruktivnym pankreatitom (obzor literatury).

OBJECTIVE: To study the literature data on pancreatogenic encephalopathy in patients with destructive pancreatitis. MATERIAL AND METHODS: Searching for Russian- and English-language literature data was carried out in electronic databases: elibrary, PubMed, the Cochrane Library. We planned a systematic review if studies with evidence level 1 and 2 were available. If these trials were absent, descriptive review was considered. RESULTS: No studies with evidence level 1 and 2 were found in available literature. Therefore, a descriptive review was carried out. Analysis of primary sources showed that the incidence of pancreatogenic encephalopathy is 9-35% and has no direct correlation with etiology of destructive pancreatitis. Major factors of pathogenesis are high serum enzymes, activation of proinflammatory cytokines and hypoxemia, which are accompanied by damage to myelin sheath of the white matter and cytotoxic brain edema. Clinical manifestation of pancreatogenic encephalopathy occurs within two weeks. Acute onset and various symptoms are typical. Possible laboratory predictors of encephalopathy are persistent hyperglycemia, increased hematocrit, fibrinogen-like protein 2 (FPB-2), proinflammatory cytokines TNF-αand interleukin-1-beta. Pancreatogenic encephalopathy is a factor of unfavorable prognosis of treatment. Mortality in patients with pancreatogenic encephalopathy is 57-70%. Favorable course of pancreatic necrosis is followed by regression of cerebral disorders in most cases while residual cognitive disorders are possible in elderly patients. CONCLUSION: Pancreatogenic encephalopathy accompanies severe destructive pancreatitis. It is an unfavorable factor for treatment outcomes requiring further research.

[Surgical treatment of chronic pancreatitis: indications, timing, methods]. / Khirurgicheskoe lechenie khronicheskogo pankreatita: pokazaniya, sroki, metody.

The review is devoted to complex treatment of chronic pancreatitis considering modern data on pathogenesis of this disease. The authors analyze various aspects of endoscopic and surgical interventions in refractory pain syndrome and complications of chronic pancreatitis, as well as positive and negative aspects of each method. Various surgical interventions and indications are analyzed in detail. One of the important points was analysis of the period between disease onset and surgical treatment that affects quality of life in patients with chronic pancreatitis in mid- and long-term period.

[Actual issues of diagnosis and treatment of diverticulitis]. / Aktual'nye voprosy diagnostiki i lecheniya divertikulita.

The authors reviewed the main researches devoted to pathophysiological mechanisms and international classification of diverticulitis, analyzed multiple-center retrospective and randomized prospective studies. Modern diagnostic and therapeutic approaches, certain unsolved problems in indications for surgeries and their technique, as well as the role of surgical interventions in prevention of recurrences and severe complications of diverticulitis are demonstrated.

[Positioning of mesh implants in endoscopic inguinal hernia repair]. / Sposoby pozitsionirovaniya setchatykh implantov pri endovideokhirurgicheskoi pakhovoi gernioplastike.

OBJECTIVE: To improve the results of endoscopic inguinal hernia repair by determining the optimal access to inguinal region and method of positioning of the mesh implant. MATERIAL AND METHODS: There were 221 patients with inguinal hernia who underwent 278 operations. We formed 2 groups: the main group A consisted of 92 (41.6%) patients who underwent extraperitoneal interventions (TEP/e-TEP); the control group B - 129 (58.4%) patients after transabdominal surgery (TAPP). In each group, 3 subgroups were identified depending on the method of mesh implant positioning: subgroups A1 and B1 - stapler reduced fixation at 1-3 points, subgroups A2 and B2 - glue fixation, subgroups A3 and B3 - vacuum positioning without fixation. Acute, chronic pain syndrome and quality of life were evaluated using visual-analogue scale (VAS), Short-Form Inguinal Pain Questionnaire (sf-IPQ) and SF-36 questionnaire, respectively. RESULTS: All interventions were completed in minimally invasive fashion. Regression of acute pain syndrome after 3, 24, 48, 72 hours and 7 days was as follows: in group A - from 3.39±0.37 to 0.53±0.18 scores, in group B - from 4.47±0.34 to 0.94±0.24 scores. The lowest values were observed in subgroups with non-invasive positioning (p<0.05). Chronic pain syndrome was evaluated by all patients as less than 2 scores in 6 months after surgery. SF-36 values after 6 months ranged from 78±1.5 to 92±1.0 at TEP/e-TEP and from 75±1.6 to 92±1.1 at TAPP. Between-group and within-group differences were not significant (p>0.05). Control examination within 0.5-2 years was performed in 189 (85.5%) patients. No relapses were detected. CONCLUSION: E-TEP technology is a priority. Glue fixation increases the congruence of mesh implants with inguinal region due to enlarged area of immobilization. This ensures safety and reliability of hernia repair, comfort for patients.

[Staged bilateral total extraperitoneal allohernioplasty by e-TEP in a patient with recurrent oblique inguinal hernia on the left and combined strangulated femoral hernia on the right]. / Étapnaia dvustoronniaia total'naia ékstraperitoneal'naia allogernioplastika po metodike e-tep u patsienta s retsidivnoi kosoi pakhovoi gryzhei sleva i kombinirovannoi ushchemlennoi bedrennoi gryzhei sprava.

A case of two-stage minimally invasive surgical treatment of an elderly patient with bilateral inguinal hernia is presented: a recurrent oblique on the left, combined (femoral, obturator, oblique and direct inguinal) on the right with incarceration and necrosis of the small intestine in the femoral canal. Previously, the patient underwent closure of perforated ulcer of duodenum from upper-midline laparotomy, epicystostomy, transvesical adenomectomy from the lower-midline laparotomy. The first stage we performed diagnostic laparoscopy, minilaparotomy, reduction and resection of necrotic small intestine loop. The second stage was carried endovideoscopic total extraperitoneal allohernioplasty by the method of Extended-View Totally Extraperitoneal (e-TEP) on two sides. The positive results of the treatment indicate a high efficiency of video endoscopic alloplasty of occult hernias in a complex case. To diagnose and perform adequate surgical intervention with a combined femoral hernia, when the obturator and inguinal hernias are formed, but clinically do not manifest themselves, it is possible only with endoscopic examination of potential sites of hernia formation in the inguinal region, which is not possible with open plastic hernia of the inguinal region.

[Application of anti-adhesive barrier for recurrent acute adhesive intestinal obstruction]. / Applikatsiya protivospaechnogo bar'era pri retsidiviruyushchei ostroi spaechnoi kishechnoi neprokhodimosti.

Surgical treatment of a patient with recurrent acute adhesive intestinal obstruction is described. Seven plates of anti-adhesive barrier agent made from oxidized regenerated cellulose were applied to small bowel in order to prevent adhesions. Control examination did not reveal viscero-parietal adhesions between hollow organs and delayed passage through the gastrointestinal tract. Long-term results indicate the need for intraoperative prevention of intra-abdominal adhesions in patients with abdominal adhesive disease.

[Single-port transumbilical dissection of multiple liver abscesses after choledochoduodenostomy]. / Odnoportovoe transumbilikal'noe vskrytie mnozhestvennykh abstsessov pecheni posle kholedokhoduodenostomii.

It is presented case report of a patient with multiple cholangiogenic abscesses of right liver lobe in 7 years after primary surgery. High efficiency of minimally invasive technologies for purulent complications of biliary surgery was emphasized. Moreover, it was confirmed that choledochoduodenostomy as a variant of internal biliary drainage is not desirable for complicated course of cholelithiasis.

[Endoscopic surgery and laparoscopy are new insights of evolution of inguinal hernia repair (in Russian only)]. / Éndovideokhirurgiia i laparoskopiia - novyi vitok évoliutsii operativnogo lecheniia pakhovykh gryzh.

This article is devoted to general and particular problems of inguinal hernia repair through the analysis of statistical data and comparison of advantages and disadvantages of various methods of inguinal hernia repair. Particular attention is paid to the analysis of current options of mesh implant fixing during endoscopic hernia repair: TAPP, TER, e-TER. Long-term outcomes are essential to determine surgical technique. The authors consider that careful adherence to the basic principles of minimally invasive surgery can reduce the incidence of complications, recurrences and chronic pain syndrome after inguinal hernia repair. The main advantages of current surgical technologies are accelerated rehabilitation, earlier restoration of social activity, improvement of the quality of life.

[Technical features of laparoscopic cholecystectomy in patients with overweight and obesity]. / Laparoskopicheskaia kholetsistéktomiia u patsientov s izbytochnoi massoi tela.

AIM: To improve surgical treatment of patients with cholelithiasis and obesity by using of different technologies of laparoscopic cholecystectomy. MATERIAL AND METHODS: There were 88 (16.4%) patients with overweight and obesity among 538 patients who underwent laparoscopic cholecystectomy. Conventional laparoscopic cholecystectomy was performed in 33 (6.1%) cases, cholecystectomy through single laparoscopic access - in 12 (2.3%), cholecystectomy via single laparoscopic access with trocar support - in 43 (8.0%) patients with body mass index 25-52.3 kg/m2. The article describes the technical features of laparoscopic cholecystectomy. RESULTS: Complications were absent in 83 (94.3%) of 88 cases after laparoscopic cholecystectomy. The lowest pain severity in early postoperative period was noted in case of single laparoscopic access (p<0.05). CONCLUSION: Conventional and single-port laparoscopic cholecystectomy is advisable in patients with calculous cholecystitis, overweight and obesity.

[Balance of hemostasis and anticoagulation therapy techniques for hip arthroplasty].

UNLABELLED: Studied a rational balance of prevention and control of blood loss and antithrombotic therapy in hip arthroplasty. MATERIAL AND METHODS: In view of literature data about significant blood loss during and after the intervention, as well as the formation of the group of patients who refuse blood transfusions for social (including religious) reasons, taken innovative methods for reducing blood loss and needs for blood transfusions. RESULTS: Complex of techniques, including conducting spinal anesthesia, controlled hypotension with nitroglycerin and pentamine, intraoperative use of systemic hemostatic and preventive use of erythropoietic stimulating agents, was formed in our proprietary technology to reduce blood loss. Its use has allowed to reach a statistically significant reduction of blood loss and transfusion rate in hip arthroplasty patients.

[Methodological and technological aspects of relaparoscopy].

Overall 3457 laparoscopic procedures after open and laparoscopic abdominal operations have been performed including 270 relaparoscopies due to intraabdominal postoperative complications. Basing on their own experience, the authors give methodological and technological recommendations allowing to increase diagnostic and surgical efficacy of relaparoscopy and to reduce the rate of complications.

[Minimally invasive technologies in diagnosis and treatment of the algesic form of adhesive disease]. / Maloinvazivnye tekhnologii v diagnostike i lechenii bolevoi formy spaechnoi bolezni.

The indications to dissection of commissures in the algesic form of adhesive disease are determined. An experience with performing 36 laparoscopic operations is described. In 34 cases adhesiolysis was fulfilled under conditions of the I-III degree of the commissural process. Technical problems appeared while dissecting commissures in 2 patients with the IV degree of the commissural process due to pronounced dystopia of organs of the abdominal cavity. No complications were registered during operations. Control examination of 29 patients did not reveal recurrent diseases.

[Laparoscopic surgery in adhesive disease]. / Laparoskopicheskie operatsii pri spaechnoi bolezni.

Experience in 2277 laparoscopic surgeries performed in patients with history of conventional and minimally invasive surgeries is analyzed. Regularities of commissures formation after some surgeries are determined. Viscero-parietal commissures (VPC) which are the main cause of possible intraoperative complications were revealed in 1746 (76,7%) patients. Diagnostic value of special ultrasonic examination was 95,5%, on the average. Laparoscopic adhesiolysis in different types of adhesive disease was attempted in 195 patients, 170 (87,2%) procedures were finished successfully. Application of Interceed (TC-7) on parietal peritoneum was used in 14 patients to prevent repeated formation of commissures.