The clinical forms of systemic neuroendocrine pathology (neuroendocrine cybernosis).

Six forms of regulation of neuroendocrine system pathology are here presented. For this pathogenic category it was proposed the term of "systemic neuroendocrine pathology" (1979) and that of "endocrine cybernosis (1971) for its clinical forms. Clinical and pathogenic peculiarities of endocrine blocking cybernoses with negative feed-back disappearance, substitution cybernose as in Graves-Basedow's syndrome and hormonal circadian rhythm troubles are described. The semiology of the clinical forms is partly known, but their pathogeny is still locally and regionally interpreted. There are primary and secondary lesions, characteristic of each clinical category of the systemic pathology, but the prevailing expression is the systemic one. The treatment of neuroendocrine cybernoses must be dominated by regulatory medication.

Blocking cybernosis in endocrine glands pathology.

The term cybernosis was proposed by Meerloo (1971) in order to designate the cybernetic functional disorders in senescence. Blocking cybernosis or bloking negative feedback is the term used for negative feedback perturbation in a neuro-endocrine subsystem caused by factors dwelling inside or outside it. Using the hypothalamo-hypophyso-adrenocortical subsystem as a model, the author shows that due to an excessive and anarchic secretion of corticoids by a tumor developed in the adrenocortical, the hypothalamo-hypophyseal control centers are blocked. A similar blockade occurs after longterm administration of high doses of a steroid, similar or identical to the natural corticoid hormone, which retro-acts like the latter. In the first case we deal with tumoral blocking cybernosis, in the second, with an iatrogenic one. As in both cases the subsystems are turned off without structural desorganization, the term blockade is more appropriate than that of disorder which implies the existence of a certain functional disability. Tumoral blocking cybernoses were seen by us in thyroid toxic adenoma, corticosteroid secreting adenomas and ovarian tumors; iatrogenic cybernoses occur in the long-term corticosteroid therapy in dermatoses, hirsutism, etc. Blocking cybernoses, both tumoral and iatrogenic, require great caution in their correction. Sudden removal of the blockade is followed by severe disorders producing collapse and coma with their implicit risk.

Tuberculous thyroiditis cured by drug therapy.

A 73-year-old patient suffering from evolutive nodular goiter, free of other local complaints or changes in the general status is presented. A diagnosis of tuberculous thyroiditis with hypothyroidism is reached. This diagnosis is justified by the antecedents of the patient, positive IDR, low iodine uptake, characteristic scintigraphic and echographic picture of the thyroid. Following a treatment with tuberculostatics, potassium iodide and controlled life regimen for a year, thyroiditis was cured as proved by scintigraphic and echographic evidence, and normal iodine uptake and PBI.

Research on the radioprotecting action of thymic polypeptides and timosterin B.

Administration of the TP2 polypeptidic thymic extract results in normalization of the rosette-forming capacity of the T spleen cells in the X-ray irradiated mouse. The radioprotecting effect was also noticed on the inhibition of macrophages migration in the X-ray irradiated rat inoculated with TH Salmonella typhi vaccine and treated with TP2 or with lipidic extract Timosterin B.

Action of thymic polypeptides of low molecular weight on some immune reactions at tissular and humoral level in guinea-pigs and mice.

Administration of the TP2 extract containing thymic polypeptides of low molecular weight (under 10,000 daltons) was found to stimulate the delayed hypersensitivity reaction in guinea-pigs injected with BCG. It was also found to reduce the hemagglutination titre in mice injected with the APR 8 influenza virus and to raise the antiflagellar agglutinins titre in rats injected with TH Salmonella vaccine. The cellular type of immune reactions was stronger than the humoral one.

Morphology of T and B lymphocytes assessed by scanning electron microscopy (SEM) in thyroiditis and Graves's disease.

Scanning Electron Microscopy (SEM) assessment of the T and B lymphocytic sub-population shows alterations in cell immunity in the thyroid gland pathology. The mean per cent figure in 10 normal individuals was 68.8 for T lymphocytes (variation range: 50-83%) and 19.6 for B lymphocytes (variation range: 11-26%); in 12 untreated cases of Graves's disease the mean figure was 78.08% for T and 16.25% for B lymphocytes. The 15 patients with untreated thyroiditis showed a mean of 83.43% for T and 12.78% for B lymphocytes. The increased number of T lymphocytes is a proof of cell immunity alteration.

Circadian rhythms of corticosterone and nucleic acids in the rat adrenal in relation to age.

For 3 successive days, at 0600, 1200, 1800 and 0000, the circadian variations of corticosterone, RNA and DNA were followed up in the adrenals of 3 lots of prebuertal (30 days old), adult (120 days old) and old (28 months old) white Wistar male rats. There is a correlation between the circadian rhythm of corticosterone secretion and the circadian rhythms of RNA and DNA synthesis all along ontogenesis. These rhythms appear to be formed at 30 days of life, but they still differ from the ones in the adult rats by the levels recorded in the second half of the nocturnal period. In old rats the adrenal circadian variations have a considerably smaller amplitude, their curve taking a plateau form. The results support the hypothesis of the circadian rhythm ontogenesis in the rat adrenal.

Changes in the bioelectric activity of the lateral septal nucleus, dorsal hippocampus and medial habenular nucleus after administration of the pineal peptide extract "crinofizin".

New Zealand rabbits with pairs of electrodes implanted chronically in the RFM, dorsal hippocampus, LSN and HM were tasted for electroencephalographic changes in the dorsal hippocampus, lateral septal nucleus and medial habenular nuclei in response to electric stimulation of the mesencephalic reticular formation and after slow i.v. and i.m. injection with the pineal peptidic extract "Crinofizin". Stimulation of RFM with a rectangular current of variable tension (1.5--4 volts) induced synusoidal waves on the EEG of the dorsal hippocampus, LSN and HM with a frequency of 4 to over 8 c/s persisting throughout the electric stimulation. Intramuscular administration of 10 ml pineal extract in doses of 2 ml every 48 hrs led to changes in the EEG traces in that the mean frequency of the synusoidal waves decreased from 3.8 c/s to 1.4 c/s whereas the mean amplitude of the waves was almost threefold the mean amplitude of the background traces.