RESUMO
In experiments on dogs, in whom a severe hemorrhagic shock was simulated the central cardiodynamics functions have been restored, the metabolic acidosis eliminated thrombocytic link of homeostasis normalized, the animals life span increased significantly under the influence of sorbilact intravenous infusion in the dose 10 ml/kg. Probable mechanisms of sorbilact therapeutic effect are considered.
Assuntos
Soluções Hipertônicas/uso terapêutico , Choque Hemorrágico/tratamento farmacológico , Animais , Cães , Feminino , Masculino , Concentração OsmolarRESUMO
A new complex action hemocorrective <
Assuntos
Substitutos Sanguíneos/uso terapêutico , Modelos Animais de Doenças , Fígado/efeitos dos fármacos , Albumina Sérica/uso terapêutico , Choque Hemorrágico/terapia , Ácido Sórbico/uso terapêutico , Doença Aguda , Animais , Cães , Avaliação Pré-Clínica de Medicamentos , Feminino , Fígado/fisiopatologia , Masculino , Choque Hemorrágico/fisiopatologia , Fatores de TempoRESUMO
Severe hemorrhagic shock was simulated in experiment on 5 dogs. The intravenous transfusion of a complex action hemocorrector Lactosorbal in the dose of 10 ml/kg provided the cardio- and haemodynamics indexes restoration, carbohydrate metabolism and acid-base equilibrium normalization, what promoted an experimental animals survival. Possible mechanisms of therapeutic action of preparation were considered.
Assuntos
Substitutos Sanguíneos , Albumina Sérica/administração & dosagem , Choque Hemorrágico/terapia , Ácido Sórbico/administração & dosagem , Animais , Substitutos Sanguíneos/administração & dosagem , Transfusão de Sangue , Cães , Estudos de Avaliação como Assunto , Feminino , Hemodinâmica , Masculino , Choque Hemorrágico/metabolismo , Choque Hemorrágico/fisiopatologiaRESUMO
A method is presented of complex medical treatment of patients with nephrolithiasis including intravenous systemic alkalinization of the urine with 1/6 M solution of sodium lactate, litholysis by citrates, use of urostatics and mineral waters of local origin. It is shown that complex medical treatment of nephrolithiasis including systemic alkalinization of the urine with a 1/6 M sodium lactate solution may be considered as a method of choice in obstructing calculi as non-operative treatment.
Assuntos
Cálculos Renais/tratamento farmacológico , Lactatos/administração & dosagem , Adolescente , Adulto , Idoso , Terapia Combinada , Avaliação de Medicamentos , Feminino , Humanos , Infusões Intravenosas , Ácido Láctico , Masculino , Pessoa de Meia-Idade , SoluçõesRESUMO
In 9 dogs with severe hemorrhagic shock, the effect of hemocorrector "Lactoprotein" on the indices of coagulative hemostasis and rheologic blood properties was studied. It was established that in intravenous transfusion of lactoprotein at a dose of 10 ml/kg permitting to lead the animals out from the state of shock, the syndromes of disseminated intravascular coagulation and high viscosity of the blood were cupped off. However, by the end of 48 hours of observation, fibrinogen level in the blood of the animals increased sharply, while antithrombin-III concentration and hematocrit decreased. Together with recommendation to use lactoprotein in the complex of shock therapy at all the stages of medical evacuation, the conclusion about necessity to perform at the early postshock period the differential component hemo- and anticoagulative therapy has been made.