Coupling of single cutaneous afferents in the hand with ankle muscles, and their response to rapid light touch displacements.

Light touch reduces sway during standing. Unexpected displacement of a light touch reference at the finger can produce rapid responses in ankle muscles when standing, suggesting cutaneous receptors in the hand are functionally coupled with ankle muscles. Using microneurography in the median nerve, we tested the hypotheses: 1) that cutaneous afferent activity of mechanoreceptors of the hand would modulate electromyographic (EMG) activity of ankle muscles, and 2) that displacement of a light touch contact across a receptor's sensory territory would be encoded in the afferent activity. Spike-triggered averaging of EMG activity of tibialis anterior (TA) and soleus (SOL) demonstrated that 34 of 42 (81%) cutaneous afferents recorded modulated activity of ankle muscles with latencies between 40 and 119 ms. Cutaneous afferents of all types (slow and fast adapting, types I and II) demonstrated responses in TA and SOL, in both the ipsilateral and contralateral leg. Activity from 11 cutaneous afferents was recorded while a light touch contact was displaced across their receptive fields. Afferent activity increased with stimulus onset and remained elevated for the stimulus duration for all afferents recorded. These results suggest that cutaneous afferents from the hand consistently form connections with motor pools of the leg at latencies implicating spinal pathways. In addition, the same population of afferents is readily excited by the displacement of a light touch contact. Therefore, cutaneous receptors of the hand can be recruited and used to alter motoneuron pool excitability in muscles important to balance control, at latencies relevant for rapid balance responses.NEW & NOTEWORTHY Light touch provides cutaneous feedback argued to contribute to balance control and shown to reduce postural sway. We demonstrate that activity of cutaneous afferents in the median nerve modulates motor pool excitability of ankle muscles at short latencies and that these afferents respond when a light touch contact is displaced. These findings suggest that cutaneous receptors of the hand can contribute to rapid regulation of muscle activity important to standing balance.

Lung volume recruitment improves volitional airway clearance in amyotrophic lateral sclerosis.

INTRODUCTION/AIMS: In this study we evaluated the effects of lung volume recruitment treatment (LVR), a low-tech, low-cost, manual "breath-stacking" technique used to help people cough with enough force to clear their airways, thereby reducing the risk of aspiration and choking, on five volitional airway clearance and protection behaviors used by people living with amyotrophic lateral sclerosis (PwALS). METHODS: Using a repeated-measures cross-over design, 29 PwALS performed five volitional airway clearance and protection behaviors in LVR treatment and in no-treatment, control conditions. Peak cough flow (PCF) was used to measure maximum expiratory rate during forced expiration, throat clearing, hawking, post-swallow coughing, and the supraglottic swallowing maneuver. Comparisons were made as a function of condition (treatment or control) and three time-points (pretreatment, and 15 and 30 minutes posttreatment). RESULTS: LVR treatment had a significant positive effect on maximum expiratory rates during all tested airway clearance and protection behaviors. Increased PCF values lasted for up to 30 minutes post-LVR for all tested behaviors in the treatment condition. DISCUSSION: We found that LVR treatment could increase control over airway clearance in PwALS, as well as provide improved airway protection for up to 30 minutes, the duration of a typical meal. This study has implications for patient care. These include offering patients control over some of the most feared symptoms of ALS, particularly choking during activities of daily living, and enhanced ALS respiratory care in low-resource settings. Findings may have implications for other neurodegenerative disorders in which dysphagia occurs with retained sensory function.

Influence of a light touch reference on cutaneous reflexes from the hand during standing.

Light touch of a stable reference reduces sway during standing. However, unexpected displacement of a light touch reference leads to short-latency reactions in ankle muscles consistent with a balance reaction, that are replaced by responses in arm muscles on subsequent trials. We anticipated that the excitability of sensorimotor pathways arising from finger cutaneous afferents would reflect these changes in behavior. We hypothesized that (1) interlimb cutaneous reflexes in muscles of the ipsilateral leg, derived from median nerve (MED) stimulation would be facilitated when touch was stable, but reduced when touch was unreliable, (2) intralimb MED reflexes in muscles of the homonymous arm would be facilitated when touch was unreliable and participants tracked the touch reference with arm movements, and (3) radial nerve (RAD) evoked reflexes would be unaffected, given that the RAD innervation territory is not involved in the light touch task. Cutaneous reflexes were evoked using a transcutaneous train of pulses (5 × 1.0 ms square-wave pulses; 300 Hz) and recorded using electromyography of muscles of the ipsilateral arm and leg. As hypothesized, interlimb MED reflexes recorded in soleus (SOL) were larger when touching the stable reference (mean ± SD % MVC; 4.78 ± 1.57) than when not touching a reference (1.00 ± 1.05) or when touching an unstable reference (1.07 ± 1.16). In addition, intralimb MED reflexes in anterior deltoid (AD) were larger when touching an unstable reference (4.50 ± 1.31), compared to touching a stable reference (1.34 ± 1.01) or not touching (1.50 ± 1.00). In contrast, interlimb RAD reflexes in SOL were larger when not touching (4.29 ± 4.34), compared with touching a stable (1.14 ± 1.84) or unstable reference (3.11 ± 4.15). These findings indicate that cutaneous reflexes from the hand are scaled with a rapid change in motor behavior when a touch reference becomes unstable, suggesting that spinal sensorimotor pathways are functionally reweighted based in part upon the reliability of tactile inputs.

Self-directed rehabilitation training intensity thresholds for efficient recovery of skilled forelimb function in rats with cervical spinal cord injury.

Task specific rehabilitation training is commonly used to treat motor dysfunction after neurological injures such as spinal cord injury (SCI), yet the use of task specific training in preclinical animal studies of SCI is not common. This is due in part to the difficulty in training animals to perform specific motor tasks, but also due to the lack of knowledge about optimal rehabilitation training parameters to maximize recovery. The single pellet reaching, grasping and retrieval (SPRGR) task (a.k.a. single pellet reaching task or Whishaw task) is a skilled forelimb motor task used to provide rehabilitation training and test motor recovery in rodents with cervical SCI. However, the relationships between the amount, duration, intensity, and timing of training remain poorly understood. In this study, using automated robots that allow rats with cervical SCI ad libitum access to self-directed SPRGR rehabilitation training, we show clear relationships between the total amount of rehabilitation training, the intensity of training (i.e., number of attempts/h), and performance in the task. Specifically, we found that rats naturally segregate into High and Low performance groups based on training strategy and performance in the task. Analysis of the different training strategies showed that more training (i.e., increased number of attempts in the SPRGR task throughout rehabilitation training) at higher intensities (i.e., number of attempts per hour) increased performance in the task, and that improved performance in the SPRGR task was linked to differences in corticospinal tract axon collateral densities in the injured spinal cords. Importantly, however, our data also indicate that rehabilitation training becomes progressively less efficient (i.e., less recovery for each attempt) as both the amount and intensity of rehabilitation training increases. Finally, we found that Low performing animals could increase their training intensity and transition to High performing animals in chronic SCI. These results highlight the rehabilitation training strategies that are most effective to regain skilled forelimb motor function after SCI, which will facilitate pre-clinical rehabilitation studies using animal models and could be beneficial in the development of more efficient clinical rehabilitation training strategies.

Retraining walking over ground in a powered exoskeleton after spinal cord injury: a prospective cohort study to examine functional gains and neuroplasticity.

BACKGROUND: Powered exoskeletons provide a way to stand and walk for people with severe spinal cord injury. Here, we used the ReWalk exoskeleton to determine the training dosage required for walking proficiency, the sensory and motor changes in the nervous system with training, and the functionality of the device in a home-like environment. METHODS: Participants with chronic (> 1 yr) motor complete or incomplete spinal cord injury, who were primarily wheelchair users, were trained to walk in the ReWalk for 12 weeks. Measures were taken before, during, immediately after, and 2-3 months after training. Measures included walking progression, sitting balance, skin sensation, spasticity, and strength of the corticospinal tracts. RESULTS: Twelve participants were enrolled with 10 completing training. Training progression and walking ability: The progression in training indicated about 45 sessions to reach 80% of final performance in training. By the end of training, participants walked at speeds of 0.28-0.60 m/s, and distances of 0.74-1.97 km in 1 h. The effort of walking was about 3.3 times that for manual wheelchair propulsion. One non-walker with an incomplete injury became a walker without the ReWalk after training. Sensory and motor measures: Sitting balance was improved in some, as seen from the limits of stability and sway speed. Neuropathic pain showed no long term changes. Change in spasticity was mixed with suggestion of differences between those with high versus low spasticity prior to training. The strength of motor pathways from the brain to back extensor muscles remained unchanged. Adverse events: Minor adverse events were encountered by the participants and trainer (skin abrasions, non-injurious falls). Field testing: The majority of participants could walk on uneven surfaces outdoors. Some limitations were encountered in home-like environments. CONCLUSION: For individuals with severe SCI, walking proficiency in the ReWalk requires about 45 sessions of training. The training was accompanied by functional improvements in some, especially in people with incomplete injuries. TRIAL REGISTRATION: NCT02322125 Registered 22 December 2014.

The effect of light touch on standing sway when the stability of the external touch reference becomes unreliable.

Lightly touching a stable reference is associated with sway reduction during standing. Unexpected displacement of the touch reference results in a false-positive balance reaction in some participants, but only with the first such disturbance. This study investigated whether light touch reduces standing sway (1) after the touch reference becomes unreliable, and (2) when participants are aware the touch reference is unreliable. 40 healthy adults, 20 that were naïve to the possibility of a touch reference displacement and 20 that were made aware prior to testing, were asked to stand while lightly touching (< 1 N) a reference with normal vision or vision occluded. Motion of the center of pressure was used to estimate standing sway before and after a single displacement, and then multiple displacements, of a touch reference. Sway area was always reduced while touching the reference, compared to standing with vision occluded without touch, even when the reference was known to be unreliable. In addition, sway area was further reduced following a single touch displacement in Naïve participants when vision was occluded. These results suggest that tactile cues from the finger interact with postural control in a complex manner, depending upon the expectation and experience of the characteristics of the touched object. Taken together, light touch can (1) be used as a spatial reference that assists in sway stabilization, (2) be a source of movement variability that impacts the performance of a skilled task, or (3) introduce noise in the sensory channels impacting fidelity.

Activation of ankle muscles following rapid displacement of a light touch contact during treadmill walking.

The first exposure of a rapid displacement of a light touch reference induces an inappropriate balance corrective response during standing in a proportion of participants that is extinguished with repeated exposures. We hypothesized that if the spatial touch reference was critical to performing of a task the evoked response would be more consistently expressed across participants and observed with repeated exposures to the disturbance. To test this, 20 participants received either forward (N = 10) or backward right-touch displacements at right-heel strike during motorized treadmill walking without visual feedback. Electromyographic recordings from four arm, four leg and one neck muscle were sampled along with joint kinematic and step cycle data. Rapid displacement of the touch surface elicited responses in all 20 participants. However, the frequency of first trial responses was not different from what was observed during standing. In contrast, responses were observed in all participants with subsequent trials. None of the participants tripped or stumbled as a result of the touch perturbations; however, the step cycle duration was consistently shorter following the first forward-touch displacement. A post-experiment questionnaire revealed that many participants often perceived the touch plate displacement as a disturbance to the treadmill belt speed, suggesting the disturbance was occasionally misinterpreted. The activation of ankle muscles following the unexpected slip of a touch reference during walking suggests that tactile information from the finger is a relevant sensory cue for the regulation and control of stepping and stability.

Balance reactions to light touch displacements when standing on foam.

We hypothesized that standing on an unstable surface would increase the relevance of light touch to standing balance, such that unexpected displacement of a touch reference would result in more consistent expression of balance corrections, compared to standing on a firm surface. Ten healthy participants stood on a foam block atop a force plate without vision, while lightly touching a reference. The touch plate was unexpectedly displaced forwards 10 times. Responses in tibialis anterior (TA) were observed more frequently across the 10 trials compared with standing on a firm surface. However, the responses evoked in trials 2-10 were functionally distinct from those following the first trial. We suggest the first trial responses represent balance corrective responses induced by the slip of the finger relative to the reference. In contrast, the subsequent responses in TA are likely related to an arm-tracking reaction that emerges, indicating a rapid repurposing of the tactile feedback.

The amplitude of interlimb cutaneous reflexes in the leg is influenced by fingertip touch and vision during treadmill locomotion.

Light touch at the fingertip has been shown to influence postural control during standing and walking. Interlimb cutaneous reflexes have been proposed to provide a neural link between the upper and lower limbs to assist in interlimb coordination during activities such as walking. In this study, we tested the hypothesis that cutaneous sensory pathways linking the arm and leg will be facilitated if subjects use light touch to assist with postural control during treadmill walking. To test this, interlimb cutaneous reflexes from the median nerve, serving the skin contact region, and radial nerve, serving an irrelevant sensory territory, were tested in the legs of subjects walking on treadmill in an unstable environment. Interlimb cutaneous reflexes were tested while subjects (a) touched or (b) did not touch a stable contact with their fingertip, and while the eyes were either (c) open or (d) closed. Reflexes arising from both nerves were facilitated when vision was removed that was then ameliorated when touch was provided. These changes in reflex amplitude during the eyes closed conditions were mirrored by changes in background muscle activity. We suggest that this facilitation of interlimb reflexes from both nerves arises from a generalized increase in excitability related to the postural anxiety of walking on a treadmill with the eyes closed, which is then restored by the provision of light touch. However, the influence of touch when the eyes were open differed depending upon the nerve stimulated. Radial nerve reflexes in the legs were suppressed when touch was provided, mirroring a suppression in the background muscle activity. In contrast, median nerve reflexes in the leg were larger when touch was provided with the eyes open, despite a suppression of background muscle activity. This nerve-specific effect of touch on the amplitude of the interlimb cutaneous reflexes suggests that touch sensory information from the median nerve was facilitated when that input was functionally relevant.

Balance-corrective responses to unexpected perturbations at the arms during treadmill walking.

The arms have been shown to be involved in the regulation of balance during walking. The use of a walking aid enhances balance by increasing the base of support and reducing the load on the legs by partly transferring it to the arms. However, when actively engaged during a balance task, perturbations to the arms can destabilize balance. Previous studies have investigated postural adjustments associated with focal arm movements during standing and walking. However, balance-corrective reactions to unexpected perturbations to the arms during walking have not been well studied. In the present study, subjects walked on a treadmill while grasping a pair of handles when sudden perturbations were delivered by displacing the handles in the forward or backward direction. Instructing subjects to oppose the displacement of the handles resulted in strong responses in the arms that were accompanied by activation of muscles in the legs, comparable to those observed in other balance disturbance studies. Conversely, when subjects were instructed to allow the handles to move when displaced, no responses were observed in the arms. However, similar responses were observed in the legs whether subjects opposed the displacement of the handles or not when perturbations were applied at heel strike. The results from this study show that balance reactions can be elicited in the legs in response to perturbations applied at the arms, and that the expression of these responses is affected by the task engaged in by the arms.

The effect of light touch on the amplitude of cutaneous reflexes in the arms during treadmill walking.

Light touch contact of the tip of one finger can influence the postural control of subjects standing or walking on a treadmill. It is suggested that haptic cues from the finger provide an important sensory cue for the control of posture. In the current study, we used intra-limb cutaneous reflexes in the arms to test the hypothesis that transmission in sensory pathways relevant to the light touch contact would be modulated when light touch is used to increase stability during walking in an unstable environment. Subjects walked on a treadmill and received periodic pulls to the waist. Cutaneous reflexes were evoked from stimulation of the median and radial nerves while the subjects either (a) lightly touched or (b) did not touch a stable contact with the tip of their index finger, while the eyes were either (c) open or (d) closed. The results showed that cutaneous reflexes were modulated by both touch and vision. The effect of touch depended on the nerve being stimulated. The provision of touch in the absence of vision resulted in facilitation of median nerve reflexes evoked in the posterior deltoid and the triceps brachii, but resulted in the suppression of radial nerve reflexes. The nerve-specific influence of touch observed in the responses suggests that cutaneous afferent pathways are facilitated in the presence of touch if they transport sensory information from functionally relevant sensory cues.

The contribution of light touch sensory cues to corrective reactions during treadmill locomotion.

The arms play an important role in balance regulation during walking. In general, perturbations delivered during walking trigger whole-body corrective responses. For instance, holding to stable handles can largely attenuate and even suppress responses in the leg muscles to perturbations during walking. Particular attention has been given to the influence of light touch on postural control. During standing, lightly touching a stable contact greatly reduces body sway and enhances corrective responses to postural perturbations, whereas light touch during walking allows subjects to continue to walk on a treadmill with the eyes closed. We hypothesized that in the absence of mechanical support from the arms, sensory cues from the hands would modulate responses in the legs to balance disturbing perturbations delivered at the torso during walking. To test this, subjects walked on a treadmill while periodically being pulled backwards at the waist while walking. The amplitude of the responses evoked in tibialis anterior to these perturbations was compared across 4 test conditions, in a 2 × 2 design. Subjects either (a) lightly touched or (b) did not touch a stable contact, while the eyes were (c) open or (d) closed. Allowing the subjects to touch a stable contact resulted in a reduction in the amount of fore-aft oscillation of the body on the treadmill, which was accompanied by a reduction in the ongoing electromyographic activity in both tibialis anterior and soleus during undisturbed walking. In contrast, the provision of touch resulted in an increase in the amplitude of the evoked responses in tibialis anterior to the backward perturbations that was more evident when subjects walked with the eyes closed. These results indicate that light touch provides a sensory cue that can be used to assist in stabilizing the body while walking. In addition, the sensory information provided by light touch contributes to the regulation of corrective reactions initiated by balance disturbances encountered during walking.

The effects of lung volume recruitment on coughing and pulmonary function in patients with ALS.

Our objective was to study the intensity and duration of the effects of lung volume recruitment, a manual breath stacking technique, on pulmonary function and coughing in individuals with amyotrophic lateral sclerosis (ALS). Twenty-nine individuals with ALS participated in this study. A cross-over research design was used to compare effects of lung volume recruitment to a control condition. Treatment outcome measures included forced vital capacity (FVC), sniff nasal pressure (SnP) and peak cough flow (PCF). Results demonstrated that LVR had a significantly positive effect on FVC for up to 15 min following treatment but did not have a facilitative effect on SnP at any time-point. LVR had a significantly positive effect on PCF during unassisted coughing at both 15 min and 30 min following treatment, and there was no significant decrease in flow rates from baseline to 30 min later. In conclusion, lung volume recruitment may be an effective treatment for improving coughing and pulmonary function in individuals with ALS. Future research should be focused on determining patient characteristics that contribute to response to treatment, as well as randomized controlled trials of the technique.

Weighted vests, stereotyped behaviors and arousal in children with autism.

The homeostatic theory of stereotyped behaviors assumes that these behaviors modulate arousal. Weighted vests are used to decrease stereotyped behaviors in persons with autism because the input they provide is thought to serve the same homeostatic function. This small-n, randomized and blinded study measured the effects of wearing a weighted vest on stereotyped behaviors and heart rate for six children with autism in the classroom. Weighted vests did not decrease motoric stereotyped behaviors in any participant. Verbal stereotyped behaviors decreased in one participant. Weighted vests did not decrease heart rate. Heart rate increased in one participant. Based on this protocol, the use of weighted vests to decrease stereotyped behaviors or arousal in children with autism in the classroom was not supported.

Training of walking skills overground and on the treadmill: case series on individuals with incomplete spinal cord injury.

BACKGROUND AND PURPOSE: Walking in the home and community is an important goal for individuals with incomplete spinal cord injury (iSCI). Walking in the community requires various skills, such as negotiating curbs, doors, and uneven terrain. This case report describes the use of a method to retrain walking overground that is intensive, variable, and relevant to daily walking (skill training). The aims of this case series were to determine the effectiveness of skill training in a small group of people with iSCI and to compare skill training with body-weight-supported treadmill training (BWSTT) in the same individuals. CASE DESCRIPTION: Four individuals who were a median of 2.7 years (interquartile range [IQR]=12.8) after iSCI participated in alternating phases of intervention, each 3 months long. All patients started with BWSTT. Two patients subsequently engaged in skill training while the other 2 patients engaged in BWSTT, after which a third phase of intervention (opposite to the second) was repeated. OUTCOMES: The Modified Emory Functional Ambulation Profile, the 10-Meter Walk Test, the 6-Minute Walk Test, the Berg Balance Scale, and the Activities-specific Balance Confidence Scale were administered before training, monthly throughout training, and 3 months after training. DISCUSSION: Overall improvements in walking speed met or exceeded the minimal clinically important difference for individuals with iSCI (> or = 0.05 m/s), particularly during the skill training phase (skill training: median=0.09 m/s, IQR=0.13; BWSTT: median=0.01 m/s, IQR=0.07). Walking endurance, obstacle clearance, and stair climbing also improved with both types of intervention. Three of the 4 patients had retained their gains at follow-up (retention of walking speed: median=92%, IQR=63%). Thus, the findings suggest that skill training was effective in this small group of individuals.

Whole-body responses: neural control and implications for rehabilitation and fall prevention.

Humans are one of the unique species that utilize bipedal gait to ambulate in our environment. Despite this fact, coordination of the arms with the legs and the rest of body is essential for many daily activities. As such, whole-body responses have emerged as the preferred strategy following perturbations to balance during both standing and walking. Complex neural circuitry may allow for this coordination through the use of propriospinal pathways linking lumbar and cervical pattern generators in the spinal cord, with supraspinal centers altering this control depending on the context of the situation. Based on these findings, we argue that whole-body reactions may be exploited for rehabilitation purposes. Preliminary results have indicated training programs designed to elicit whole-body responses are effective in reducing falls and improving functional mobility in older adults with and without neurological impairment.

Adaptation of cutaneous stumble correction when tripping is part of the locomotor environment.

We recently showed that cutaneous reflexes evoked by stimulating the superficial peroneal (SP; innervates foot dorsum) nerve are modulated according to the level of postural threat. Context-related modulation was observed mainly in contralateral (c) responses but not in the ipsilateral responses. This lack of effect on ipsilateral (i) cutaneous reflexes might have been caused by the general nature of the whole body perturbation. We therefore hypothesized that context-relevant mechanical perturbations applied to the dorsum of the foot by an instrumented rod at early swing during walking would produce differences in ipsilateral cutaneous reflex amplitudes, consistent with the functional relevance of the SP nerve in stumble correction responses. Subjects walked on a motorized treadmill under four conditions: 1) normal, 2) normal with mechanical perturbations at the foot dorsum, 3) arms crossed, and 4) arms crossed with mechanical perturbations at the foot dorsum. Electrical stimulation of the SP nerve was delivered at five phases of the step cycle, and cutaneous reflexes were compared between all conditions for each phase of the step cycle. Reflex responses were generally found to be modulated in amplitude during walking conditions in which mechanical perturbations were delivered, particularly in ipsilateral tibialis anterior (iTA), which showed a marked reduction in inhibition. The results indicated cutaneous reflexes in iTA and contralateral medial gastrocnemius (cMG) were influenced by the threat of a trip, induced by applying mechanical perturbations to the foot dorsum during walking. This task-related gating of cutaneous reflexes was not generalized to all muscles, thus suggesting a functional role in the maintenance of stability during locomotion.

Context-dependent modulation of interlimb cutaneous reflexes in arm muscles as a function of stability threat during walking.

Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in the leg muscles after stimulation at the foot are modulated according to the level of postural threat during walking. We hypothesized that the amplitude of interlimb cutaneous reflexes would similarly be modulated when subjects walk in unstable environments. Subjects walked on a treadmill under four walking conditions: 1) normal; 2) normal with unpredictable anterior-posterior (AP) perturbations; 3) arms crossed; and 4) arms crossed with unpredictable AP perturbations. Interlimb reflexes evoked from electrical stimulation of the right superficial peroneal or sural nerves were recorded bilaterally, at four points of the step cycle. These reflexes were compared between conditions in which the arms were moving in a similar manner: 1) normal versus AP walking and 2) arms crossed versus arms crossed with AP perturbations. Differences in reflex amplitudes between arms-crossed conditions were observed in most upper limb muscles when subjects were perturbed while walking compared with undisturbed walking. This effect was less apparent when the arms were swinging freely. The results indicate that the strength of interlimb connections is influenced by the level of postural threat (i.e., the context of the behavior), thereby suggesting that these reflexes serve a functional link between the legs and arms during locomotion.

Control of frontal plane motion of the hindlimbs in the unrestrained walking cat.

This study describes the patterns of activity of hip abductor and adductor muscles and relates their activity to the frontal plane motions of the hindlimbs during unrestrained walking in the cat to provide insight into the function of these muscles in maintaining stability during walking. Electromyographic activity was recorded from hindlimb muscles while cats walked across a walkway. Four video cameras were used to record the movement of the animal in three dimensions. To further delineate the role of the hip abductors and adductors in regulating frontal plane movements of the legs, medial-lateral translations of the walking surface were periodically introduced. During walking, the hip abducts throughout much of the stance phase and adducts during swing. Normally, the abductors and adductors are co-active during much of the stance phase and are quiescent during swing. Consequently, the adduction observed during swing is likely the result of passive events. It is argued that the activity of the hip abductors during stance phase plays a prominent role in regulating frontal plane motion of the legs during walking. However, when medial-lateral stability is disturbed, both the hip abductors and adductors respond to stabilize the frontal plane motion of the body mass while also adjusting the frontal plane swing trajectory and subsequent paw placement. The balance corrective reactions observed in the cat after medial-lateral perturbations of the support surface reasonably approximate the reactions observed previously in humans, indicating that the cat is a reasonable model to explore the neural mechanisms of lateral stability during walking.

Neural control of walking balance: if falling then react else continue.

Many different corrective reactions can be used to regain balance during walking. However, the nervous system does not hesitate to decide which reaction will be used. A rule-based finite state control system that preselects appropriate reactions is a practical way to simplify this task. The proposed model suggests that much of this is achieved by groups of spinal interneurons.