RESUMO
Introduction: Metastasectomy of oligometastatic prostate cancer has the potential to contribute to improving prognosis. We report on a case of metastasectomy of solitary liver tumor after radical prostatectomy. Case presentation: An 80-year-old man underwent radical prostatectomy for prostate cancer, followed by radiotherapy after the operation because of increased serum prostate-specific antigen levels of 0.529 ng/mL. Levels increased further to 0.997 ng/mL even after salvage therapy. The patient then received androgen deprivation therapy. Levels remained stable for 3 years, but rapidly increased to 19.781 ng/mL in the following 6 months. Abdominal computed tomography revealed a solitary liver tumor, and no metastasis to other sites was identified. The patient underwent liver segmentectomy. Microscopic examination of excised specimens revealed prostate cancer cells. Five years after surgery, serum prostate-specific antigen maintained to the lowest level so far. Conclusion: Metastasectomy might be a beneficial therapeutic option to improve the prognosis for solitary metastasis from prostate cancer.
RESUMO
A 79-year-old woman with symptomatic pyloric stenosis was diagnosed with advanced gastric cancer. CT revealed that the tumor had invaded into the pancreatic head.Since no contraindications were found at laparotomy, we performed pancreatoduodenectomy. The histopathologic diagnosis was pT4b (panc), pN3a (11/35), P0, CY0, H0, M0, pStage â ¢C, R0. The patient received adjuvant chemotherapy with S-1 for 1 year. The patient has survived without recurrence for more than 2 years. The efficacy of pancreatoduodenectomy for advanced gastric cancer is still controversial. Pancreatoduodenetomy may be indicated for selected cases of advanced gastric cancer, if an R0 resection can be achieved.
Assuntos
Pâncreas/cirurgia , Neoplasias Gástricas/cirurgia , Idoso , Antimetabólitos Antineoplásicos/uso terapêutico , Combinação de Medicamentos , Feminino , Gastrectomia , Humanos , Invasividade Neoplásica , Ácido Oxônico/uso terapêutico , Pâncreas/patologia , Pancreaticoduodenectomia , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/patologia , Tegafur/uso terapêutico , Fatores de TempoAssuntos
Esclerose Cerebral Difusa de Schilder/fisiopatologia , Hipóxia-Isquemia Encefálica/diagnóstico , Doença de Parkinson/diagnóstico , Idoso , Astrócitos/patologia , Atrofia/patologia , Feminino , Humanos , Hipóxia-Isquemia Encefálica/complicações , Imageamento por Ressonância Magnética , Neurônios/patologia , Doença de Parkinson/complicações , Tegmento Mesencefálico/patologiaAssuntos
Encéfalo/patologia , Hipóxia-Isquemia Encefálica/patologia , Emaranhados Neurofibrilares/patologia , Doença de Parkinson/patologia , Paralisia Supranuclear Progressiva/patologia , Proteínas tau , Idoso , Biomarcadores , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Diagnóstico Diferencial , Erros de Diagnóstico/prevenção & controle , Feminino , Humanos , Hipóxia-Isquemia Encefálica/metabolismo , Hipóxia-Isquemia Encefálica/fisiopatologia , Emaranhados Neurofibrilares/metabolismo , Doença de Parkinson/metabolismo , Doença de Parkinson/fisiopatologia , Valor Preditivo dos Testes , Coloração e Rotulagem , Paralisia Supranuclear Progressiva/fisiopatologia , Expansão das Repetições de TrinucleotídeosRESUMO
A 49-year-old woman underwent upper gastrointestinal endoscopic examination for epigastric discomfort, revealing giant folds on the greater curvature of the stomach. Histological examinations of biopsy specimens taken from the giant folds showed signs of chronic inflammation, and Helicobacter pylori was also identified. She underwent first-step H. pylori eradication. On follow-up endoscopy, H. pylori was not identified. However, endoscopic findings were unchanged and repeated biopsies showed dense infiltration of atypical plasma cells. No proliferation of centrocyte-like cells was seen. Immunohistochemically, plasma cells were positive for lambda-chain. Primary gastric plasmacytoma was diagnosed. Total gastrectomy was carried out with splenectomy and regional lymph node dissection. The patient remains disease free as of 6 years postoperatively.