RESUMO
N,N'-methylenebis(acrylamide) (MBA)-crosslinked poly(acrylic acid) (PAA) particles with low degree of cross-linking were synthesized using distillation precipitation polymerization. Size and size distribution of particles were obtained using dynamic light scattering and field emission scanning electron microscopy( and results showed that microspheres had a narrow size dispersity. Proton nuclear magnetic resonance results indicated that amount of cross-linker in structure of particles is a little more than the molar percentage of feeded MBA because of greater activity ratio of MBA than AA. pH-responsive behavior of samples was investigated using UV-vis. absorption at 480 nm where each sample showed a sudden deplete in UV absorbance at a peculiar pH. Synthesized particles were used as carriers of anti-cancer drug doxorubicin using two different approaches including physically loading of drug and drug conjugation via an acid-labile hydrazone linkage. Release results showed that in the first case, amount of released drug has an inverse relationship with the amount of cross-linker in the structure and also, by adding an acid-labile linkage, the amount of burst release decreased drastically. Also, the amount of released drug for conjugated systems was much lesser than particles with physically loaded drug. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 342-348, 2018.