[On the neurophysiological basis of color-impulse therapy in pathogenic treatment of eye diseases].

Color-impulse therapy (CIT) is one of the accepted treatment options in current ophthalmology. Many publications deal with the effect of CIT on eye diseases, however its pathogenic basis is poorly studied. An attempt to explain CIT effect from the neurophysiological point is made. Survey of number of publications is performed to prove sanogenic effect of CIT on pathogenesis of different pathological eye conditions.

[Peripheral blood circulation in the skin and the regulatory mechanisms in the course of primary transmural myocardial infarction].

Laser Doppler flowmetry was used to study the indicators characterizing the peripheral blood circulation in the skin, regulatory mechanisms, and the compensatory capacities of the microcirculatory bed in 32 patients aged 45-60 years in the course of primary transmural myocardial infarction during exercise tests. Significant disturbances of the mechanism responsible for regulating the peripheral blood circulation system and chiefly its active components were detected in the presence of adequate blood filling of microvessels. There was a drastic decrease in the reserves of skin microvascular endothelial activity during ionophoresis of sodium nitroprusside and acetylcholine, the maximum degree of disturbances being observed on day 10 of myocardial infarction development.

[The effect of thymic peptides on the development of streptozotocin-induced diabetes mellitus]. / Vliianie peptidov timusa na razvitie streptozototsinindutsirovannogo sakharnogo diabeta.

Streptosotocin was administered to 21 test animals and 19 control ones. Preventively, the former were given T-activin, the latter--saline. 73% of the test animals were free of hyperglycemia, insulinopenia, activation of lipid peroxidation, morphologic evidence of beta-cell damage. In control animals diabetes mellitus arose in 84% manifesting with marked hyperglycemia, insulinopenia, LPO activation, morphological signs of beta-cell damage, lymphocytic infiltration of the islets. From the results obtained it can be concluded that T-activin has a prominent protective effect against diabetes mellitus (chi-square = 6.34, p < 0.05) which can be explained by its antioxidant and immunotropic activity.

[Effect of low-intensity laser irradiation as affected by maximum tolerable exercise]. / Vliianie nizkointensivnogo lazernogo izlucheniia pri deistvii na organizm predel'no dopustimoi fizicheskoi nagruzki.

The investigations on albino noninbred male rats showed that low-intensity laser radiation ("Uzor" semiconductor laser, wavelength 0.89 mu, 1500 Hz, exposure 8 min) substantially increased physical work capacity during the maximum tolerable exercise. In addition, the plasma concentrations of thyroxine and malonic dialdehyde increased and the levels of lactic acid and triiodothyronine decreased.

[Study of the glucocorticoid function of the adrenals in patients with diabetes mellitus using a minor dexamethasone test]. / Issledovanie gliukokortikoidnoi funktsii nadpochechnikov u bol'nykh sakharnym diabetom s pomoshch'iu malogo deksametazonovogo testa.

The purpose of the paper is to define the state of glucocorticoid function in 37 male and female patients with types I and II diabetes mellitus of various degree of compensation before and after dexamethasone blockade of the hypothalamohypophyseoadrenal system (0.5 mg 4 times for 2 days). The level of cortisol in the plasma was determined by a radioimmunoassay using Sorin kits. Statistical data processing was performed using the d-3-28 computer. In patients with types I and II diabetes mellitus at the stage of compensation the level of plasma cortisol did not differ from that of persons without diabetes mellitus; in decompensation of types I and II diabetes mellitus its considerable increase was noted. After the dexamethasone test the more pronounced was a degree of decompensation of diabetes mellitus, the higher was the level of cortisol, i.e. there was resistance to dexamethasone inhibiting action, especially in type I which could be accounted for by deeper metabolic derangements in this type of diabetes mellitus and an increase in the threshold of sensitivity of the hypothalamic centers to dexamethasone. Therefore the minor dexamethasone test could be used for determination of a degree of metabolic compensation of patients with diabetes mellitus.

[Functional state of the thyroid gland during systemic graft vs host reaction]. / Funktsional'noe sostoianie shchitovidnoi zhelezy pri sistemnoi reaktsii transplantat protiv khoziaina.

Triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) serum content was measured in mice during systemic "graft-versus-host" reaction (GVHR), using radioimmunoassay. It was demonstrated that on the 3rd day after GVHR induction the levels of these hormones did not differ from the control values. T3 and T4 concentrations and 125I absorption by thyroid gland diminished by day 10. At the same time TSH level remained unchanged. On day 24 after GVHR induction T3 and T4 content was significantly reduced, although TSH concentration exceeded the control value. 125I absorption was enhanced as compared to the value observed on day 10. The data obtained show the vigorous inhibition of thyroid gland function during systemic GVHR.

[Hypophyseal-thyroid system function of animals in the early periods after tumor transplantation]. / Funktsional'noe sostoianie gipofiz-tireoidnoi sistemy zhivotnykh v rannie sroki posle perevivki opukholi.

The signs of disintegration of hypophyseal-thyroid system function with predominant iodine uptake by thyroid gland cells are detected in the animals during the first 3 days after sarcoma M-1 inoculation. Dissimilar changes in magnesium ion levels are seen in the peripheral blood plasma and thyroid tissue homogenate of the animals with inoculated tumor and injected with non-specific antigenic stimulant.

[Further study of the hormonal regulation of natural immunity to weak transplantation antigens in inbred mice]. / Dal'neishee izuchenie gormonal'noi reguliatsii estestvennogo immuniteta k slabym transplantatsionnym antigenam u inbrednykh myshei.

Blood plasma corticosterone level and the extent of immunological reaction to sex-antigen of skin transplant in inbred mice CBA, C57Bl/6, F1 (CBA X 57Bl/6), C3H, AKR was compared. Mice CBA had a high blood plasma corticosterone level and no immunological reaction to sex-antigen. A lower blood corticosterone level and the presence of reaction to sex-antigen was characteristic of mice C57Bl/6, AKR, C3H, F1(CBA X C57Bl/6). The number of endogenous colonies in the spleen of mice CBA was less than in mice C57Bl/6. Mice CBA had a narrow cortical thymus layer in comparison with the wide thymus cortex of mice AKR and C57Bl/6. Adrenalectomy of mice CBA caused a sharp widening of the thymus cortex.

[Indices of body resistance to overheating in the dynamics of acute radiation lesion]. / Nekotorye pokazateli ustoichivosti organizma k peregrevaniiu v dinamike ostrogo luchevogo porazheniia.

Three hours after irradiation in a dose of 800 R rats proved to be less resistant to following overheating (45 degrees C) than control animals. An increase of resistance to acute overheating was revealed at the end of 3 days after the irradiation. At the height of the radiation disease (the end of the 5th day) the period of occurrence of heat stroke and the duration of rat survival failed to differ from those in the control animals. The dynamics of response to overheating correlated to some extent with that of the thyroid gland and the adrenal gland functions in the irradiated animals.

[Thyroid gland function in heatstroke]. / Funktsiia shchitovidnoi zhelezy pri teplovom udare

Development of thermal stroke in rats with the action of high external temperature (45 degrees C) was accompanied by a reduction of accumulation of I131 in the thyroid gland, a fall in the protein-bound-iodine--I131 and in the amount of thyroxin in the peripheral blood plasma, and also by a fall in the rate of disappearance from the blood of Nal131 injected intravenously. A relative decrease of the content of mono- and particularly of diiodthyrosines, and also, slightly, of iodthyronines occurred in the trypsine hydrolyzates of the thyroid gland at the moment of the thermal stroke development.