RESUMO
This study investigated the antioxidant activity of Cuphea glutinosa (CG) and its effect on Na+, K+-ATPase from cardiac muscle. The ethanolic extract showed higher antioxidant capacity compared to aqueous and ethyl acetate fraction. Ethyl acetate fraction showed ß-sitosterol-3-O-ß-glucoside, kaempferol, quercetin, isoquercetin, gallic acid methyl ester, and gallic acid. The ethanolic extract also reduced the Na+,K+-ATPase activity. CG presented a promising antioxidant activity and inhibitory effect on the Na+, K+-ATPase activity, supporting biochemical evidences the popular use of this plant in the treatment of heart failure.
Assuntos
Antioxidantes/isolamento & purificação , Cuphea/química , Compostos Fitoquímicos/química , ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores , Animais , Antioxidantes/química , Brasil , Coração/efeitos dos fármacos , Insuficiência Cardíaca/tratamento farmacológico , Quempferóis/isolamento & purificação , Miocárdio , Extratos Vegetais/química , Quercetina/isolamento & purificaçãoRESUMO
Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3ß,25-diol, the disaccharide α,ß-trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities.