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1.
Oral Dis ; 2024 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-38191825

RESUMO

OBJECTIVE: Malignant soft tissue sarcoma (MSTS) is a rare disease, but is seen in patients undergoing orthopedic surgery. Although the association of periodontal disease with various cancers occurring in the oral cavity, gastrointestinal tract, lungs, and prostate, has been reported, the association between periodontal disease and MSTS remains unclear. This study investigated the association between periodontal disease and MSTS in patients undergoing orthopedic surgery. SUBJECTS AND METHODS: One hundred fifteen patients who underwent orthopedic surgery between 2017 and 2021 were retrospectively enrolled (mean age = 66.8 ± 10.7 years). The patient background was adjusted by the propensity score (PS). Subsequently, the association of periodontal disease with MSTS was analyzed using PS inverse probability of treatment weighting (IPTW). Periodontal status was determined by evaluating the periodontal inflamed surface area, which was calculated by measuring the periodontal probing pocket depth and detecting bleeding on probing. RESULTS: Multivariate logistic regression analysis after adjustment by the PS showed that severe periodontitis was significantly associated with MSTS (odds ratio 2.81, p = 0.04). Furthermore, IPTW showed that severe periodontitis was significantly associated with MSTS (odds ratio 3.21, p = 0.01). CONCLUSION: The results indicate an association between periodontal inflammation and MSTS.

2.
Int J Dent Hyg ; 22(2): 394-400, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-36760162

RESUMO

OBJECTIVES: This study examined the association between the number of remaining teeth and the incidence of postoperative respiratory complications in patients undergoing heart valve surgery. METHODS: We retrospectively enrolled 157 patients who underwent heart valve surgery between April 2010 and March 2019. Data on patient characteristics including systemic and oral conditions were extracted and postoperative respiratory complications were set as outcomes. Patients were divided into two groups according to the number of remaining teeth (≥20, <20). After adjusting for confounding factors with propensity scoring, logistic regression analysis was performed to examine the association of remaining teeth number with the incidence of postoperative respiratory complications. In addition, subgroup analysis was performed by stratifying the data into quintiles based on the propensity score. RESULTS: Univariate analysis showed significant differences between the two groups in factors, including age, past cardiac surgery experience, New York Heart Association functional classification class IV, denture use, tooth extraction before surgery, occlusal support, and periodontitis. Logistic regression analysis showed that patients with <20 remaining teeth had a significantly higher incidence of postoperative respiratory complications than those with ≥20 remaining teeth, with an odds ratio of 29.800 (p = 0.004). Subgroup analysis showed that the odds ratio for the patients with <20 remaining teeth was 9.000 (p = 0.038). CONCLUSIONS: The results suggest that heart valve surgery patients shall get attention on oral disease prevention by dental care practitioners to maintain a sufficient number of teeth for the prevention of postoperative respiratory complications.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Humanos , Estudos Retrospectivos , Fatores de Risco , Complicações Pós-Operatórias/epidemiologia , Valvas Cardíacas/cirurgia
3.
Oral Dis ; 29(3): 1324-1332, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34923726

RESUMO

OBJECTIVE: There is a well-known relationship between oral hygiene and infective endocarditis. Epidemiological evidence regarding perioperative oral management (POM) for cancer surgery has been accumulated, but this evidence is not sufficient for cardiac surgery. Therefore, our purpose was to investigate whether POM can prevent postoperative complications in patients undergoing heart valve surgery. SUBJECTS AND METHODS: Using single-arm medical information, we retrospectively enrolled 301 patients who underwent heart valve surgery between April 2010 and March 2019. The patient background was adjusted by the propensity score (PS). We then analyzed the impact of POM on postoperative bloodstream infection (PBSI), postoperative pneumonia, and mortality using PS inverse probability of treatment weighting (IPTW). RESULTS: IPTW revealed that the POM group had a lower incidence of PBSI than the control group, with an odds ratio of 0.316 (p = 0.003). The mortality in the POM group was significantly lower than that in the control group (p = 0.023). Fourteen patients died in the present study and 6 of them were infection-related. CONCLUSIONS: POM was significantly associated with decreased incidence of PBSI and mortality. The results suggest that POM is beneficial for the prevention of PBSI and mortality in patients undergoing heart valve surgery.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Sepse , Humanos , Estudos Retrospectivos , Complicações Pós-Operatórias/prevenção & controle , Valvas Cardíacas/cirurgia
4.
Support Care Cancer ; 30(12): 10285-10290, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36239800

RESUMO

PURPOSE: During head and neck radiotherapy, backscatter from metallic dental restorations (MDRs) causes oral mucositis. Currently, two MDR handling methods are used: the replacement of MDRs with provisional restorations (MDR removal) and fabrication of dental spacers before radiotherapy. We compared the effects of these two methods on the incidence of oral mucositis during head and neck radiotherapy. METHODS: We enrolled 76 patients with MDRs who underwent radiotherapy for head and neck cancer between April 2016 and March 2020. We set grade 2 oral mucositis as an outcome. After adjustment of all covariates using the propensity score (PS), we analyzed the data using a Cox proportional hazards model. In addition, subgroup analysis was performed by stratifying the data into quintiles based on the PS. RESULTS: For the incidence of grade 2 oral mucositis due to head and neck radiotherapy, the hazard ratio for the MDR removal group relative to the dental spacer group was 0.344 (95% confidence interval, 0.121-0.980; P = 0.046). Subgroup analysis showed that the hazard ratio for the MDR removal group was 0.339 (95% confidence interval, 0.122-0.943; P = 0.038). CONCLUSION: The results suggest that MDR replacement is superior to dental spacer fabrication in reducing the incidence of oral mucositis during head and neck radiotherapy, although MDR removal carries several associated risks.


Assuntos
Neoplasias de Cabeça e Pescoço , Estomatite , Humanos , Estomatite/epidemiologia , Estomatite/etiologia , Estomatite/prevenção & controle , Neoplasias de Cabeça e Pescoço/radioterapia , Neoplasias de Cabeça e Pescoço/complicações , Radioterapia/efeitos adversos
5.
Int Dent J ; 72(6): 819-824, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35525805

RESUMO

OBJECTIVES: The effect of perioperative oral management on the prevention of postoperative complications remains unclear in cardiac surgery. Exploratory factor analysis was performed to examine whether a lack of perioperative oral management was associated with postoperative complications of heart valve surgery. MATERIALS AND METHODS: We retrospectively enrolled 365 patients who underwent heart valve surgery between April 2010 and March 2019. We extracted data on patient characteristics and set postoperative pneumonia and postoperative bloodstream infection as outcomes. A logistic regression analyses were performed to examine the effect of factors on the incidence of postoperative complications. RESULTS: Significant risk factors for postoperative pneumonia included dialysis, long operative time, and long-term intubation. Similarly, risk factors for postoperative bloodstream infection were long-term intubation and lack of perioperative oral management. Subsequently, we identified the risk factors for long-term intubation, which were common to both complications, and found they were emergency status, combined valvular disease, long operative time, and lack of perioperative oral management. CONCLUSIONS: We demonstrated that a lack of perioperative oral management could be a risk factor for postoperative bloodstream infection and long-term intubation in heart valve surgery. The results suggest that perioperative oral management is effective in preventing postoperative complications of heart valve surgery.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Assistência Perioperatória , Pneumonia , Sepse , Humanos , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Valvas Cardíacas/cirurgia , Pneumonia/prevenção & controle , Complicações Pós-Operatórias/prevenção & controle , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
6.
Chem Biodivers ; 9(2): 318-30, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22344908

RESUMO

Three prenylated chalcones, 4-hydroxyderricin (1), xanthoangelol (2), and xanthoangelol F (3), isolated from Angelica keiskei, were transformed by the fungus Aspergillus saitoi. These chalcones were converted to flavanones (i.e., 4, 8, and 12), and prenyl-chain-hydrated (i.e., 5, 7, 9-11, and 13) and ring-B-hydroxylated (i.e., 6) chalcones. The structures of three new metabolites, 7, 9, and 13, were established as 2″,3″-dihydro-4,3″-dihydroxyderricin, 6″,7″-dihydro-7″-hydroxyxanthoangelol, and 6″,7″-dihydro-7″-hydroxyxanthoangelol F, respectively. Upon evaluation of cytotoxic activities of compounds 1-13, the metabolite 7 exhibited potent cytotoxicity against HL60 cells, and this cell death was revealed to be mostly due to apoptosis. In addition, compounds 1-4, 7-10, 12, and 13 were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. All compounds tested showed inhibitory effects against EBV-EA activation with potencies higher than that of ß-carotene. Furthermore, the metabolite 13 exhibited inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter.


Assuntos
Angelica/química , Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Transformação Celular Neoplásica/efeitos dos fármacos , Chalconas/farmacologia , Neoplasias Cutâneas/prevenção & controle , 9,10-Dimetil-1,2-benzantraceno/toxicidade , Animais , Antígenos Virais/metabolismo , Aspergillus/efeitos dos fármacos , Aspergillus/crescimento & desenvolvimento , Testes de Carcinogenicidade , Carcinógenos/toxicidade , Chalconas/química , Humanos , Camundongos , Estrutura Molecular , Prenilação , Neoplasias Cutâneas/induzido quimicamente , Acetato de Tetradecanoilforbol/farmacologia , Células Tumorais Cultivadas
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