[Multiple cerebral infarcts associated with livedo secondary to anti-cancer therapy with interleukin 2 and interferon alpha]. / Infarctus cérébraux multiples associés à un livedo secondaires à un traitement anticancéreux par interleukine 2 et interféron alpha.

Anticancer drugs rarely cause strokes. We report the case of a woman treated for a kidney cancer by IL2 and IFN alpha, having developed multiple strokes associated with a livedo. The responsibility of IL2 and IFN alpha seemed likely. The association with a transitory livedo suggested that the pathological process might be a cerebral angiopathy with arterial vasospasms.

[Human orf and erythema multiforme]. / Orf et érythème polymorphe.

BACKGROUND: Orf is a disease of sheep due to a parapoxvirus. Transmission in man is possible, and is generally benign, self-limited condition. Although, rare complications have been mentioned. We report a case of Orf with erythema multiforme in a young girl. CASE REPORT: A 13-year-old girl presented to our department with an erythema multiform. The cutaneous examination revealed painless erythematous nodule of her right index finger developed 15 days after a contact with a lamb. The diagnosis of Orf complicated by erythema multiforme was made on the basis of her typical history. Lesions heal with symptomatic therapy in 15 days. DISCUSSION: Orf presents in sheeps as a pustular dermatitis or a vesicular oral mucosal lesions, and in man as a single lesion on the site of infection. This lesion generally heals without complications, although secondary infection is not uncommon. Twenty one cases of erythema multiforme have been recorded following infection with the Orf virus. In typical cases, the diagnosis is established by a history of contact with infected animals and the appearance of the lesion. Electron microscopic examination can be helpful sometimes. Lesions regress in 4 to 5 weeks without specific treatment.

[Multifocal angioeccrine hamartoma associated with venous insufficiency]. / Hamartome angioeccrine plurifocal associé à une insuffisance veineuse.

INTRODUCTION: Angioeccrine hamartoma is an uncommon skin disease. The typical aspect is that of a sometimes painful hemangioma often associated with localized hypersudation. There is almost always only one lesion, generally with a distal localization. Angioeccrine hamartoma usually occurs in childhood but neonatal and adult forms have been described. CASE REPORT: We observed a case of plurifocal angioeccrine hamartoma on the lower left limb in a 55-year-old man with homolateral venous insufficiency. DISCUSSION: The plurifocal nature of the lesions and the association with venous insufficiency in the same territory would suggest that vascular disorders would be an underlying factor, especially since treatment of the venous disorder lead to initial improvement in the skin manifestations.