[Role of membrane protectors and antioxidants in the process of perfusion and preservation of donor lungs]. / Rol' membranoprotektorov i antioksidantov v protsesse perfuzii i konservatsii donorskikh legkikh.

Comparative study of the effect of four perfusion and preservation solutions on lung function, conducted in experiments on 69 inbred dogs, revealed the following regular features. Euro-Collins and electrolyte solutions cause a marked increase of the capillary-hydrostatic pressure, a significant decrease of colloido-osmotic pressure of the plasma, and, as a result, reduction of the ient between them. This is manifested by edema of the lungs. The use of LPD solution is attended by moderate edema of the lungs in moderately increased capillary hydrostatic pressure and mildly reduced colloido-osmotic pressure of the plasma. Perfusion and preservation of the lungs with the LPD solution, containing membrane protectors and antioxidants, for 12 hours is marked by practically unchanged indices of capillary-hydrostatic pressure, plasma coloido-osmotic pressure, and the gradient between them. Edema of the lungs does not develop in this case.

[The quality of the preservation of lungs using different solutions (an experimental study)]. / Kachestvo konservatsii legkikh razlichnymi rastvorami (éksperimental'noe issledovanie).

Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.

Extracorporeal mechanical pulsatile pump and its significance for myocardial function recovery and circulatory support.

The authors performed 12 acute (on dogs) and 12 chronic (on calves) assisted circulation experiments with the use of the total extracorporeal mechanical pump (TEMP) artificial ventricles. The functional morphological research of the myocardium suggests that in addition to the possibility of the biological heart function full replacement, the artificial ventricle also helps recover damages in both the myocardial infarction and distal zones. The critical time period up to the onset of artificial circulation is not more than 2 h, and after that myocardial changes are irreversible.

[Use of left cardiac shunting in severe acute heart failure]. / Primenenie levostoronnego shuntirovaniia serdtsa pri tiazheloi ostroi serdechnoi nedostatochnosti.

The efficiency of assisted circulation by means of an artificial ventricle joined in through left atrial-aortal shunt in severe cases of acute heart failure was assessed in an experimental study on calves. Myocardial insufficiency was produced by coronary ligation. Assisted circulation was conducted for 2-6 hours. The recovery of cardiac pumping function was noted in 56.3% of observations, an evidence of high efficiency of the method. The experimental results showed the efficiency of an asynchronous operation regimen of the artificial ventricule in the presence of acute arrhythmias and hypotension.