Impact of Initiating Screening Programs on Referral and Management of Cervical Cancer in Tanzania.

PURPOSE: We investigated the impact of screening rural patients on referral and management of cervical cancer in Tanzania. METHODS: After reviewing more than 10,000 medical records of patients with cervical cancer who visited Ocean Road Cancer Institute (ORCI) from 2005 to 2014, 108 patients were from the rural communities of Bagamoyo and Chalinze. We abstracted demographic, clinical, and lifestyle factors and linked the data set to databases of all 1,151 patients who visited the Bagamoyo screening clinic from 2011 to 2014 and 1,273 patients who visited the Chalinze screening clinic from 2012 to 2014. RESULTS: After initiation of the rural screening clinics, difference in duration from diagnosis to prescribed treatment increased from 50.5 to 88 days (P = .030), and duration from referral to treatment increased from 38.6 to 101.3 days (P = .041). Proportion of patients who received combination chemoradiotherapy increased from 34.3% to 69% (P = .001) and completion of treatment decreased from 94.4% to 72.41% (P = .002) after initiation of the ORCI screening clinic. Patients who visited Muhimbili National Hospital had significantly shorter periods between referral and prescribed treatment than patients who did not use the Muhimbili National Hospital (mean ± standard deviation, 49.4 ± 128.8 and 112.1 ± 195.31 days, respectively; P = .010). Patients who were treated at ORCI had significantly shorter periods between diagnosis and referral to treatment (mean ± standard deviation, 31.4 ± 62.35 and 36.4 ± 121.79 days, respectively; P = .005). CONCLUSION: Future research should focus on investigating barriers to seeking cancer care, benefits of chemoradiotherapy in this population considering the change in prescribed treatment, and time until diagnosis and treatment. Prescription of complex treatments that require more visits to treatment centers may also contribute to decline in completion of treatment.

Changing Patterns of lung, liver, and head and neck non-AIDS-defining cancers relative to HIV status in Tanzania between 2002-2014.

BACKGROUND: Tanzania, like other low-income countries, has an increasing cancer burden that remains underestimated. Infection-associated malignancies, particularly HIV-infection, represent a great proportion of cancer burden in Tanzania and throughout Africa. Availability of HIV treatment and improved survival of HIV patients are suggested factors related to increasing prevalence of non-AIDS-defining cancers (NADCs). This study examined patterns of NADCs and proportions of HIV-positivity at the Ocean Road Cancer Institute (ORCI). METHODS: We reviewed logbooks of all ORCI patients diagnosed and/or treated for lung, liver, and head and neck cancers during 2002-2014. The number of total cancers diagnosed at ORCI during this period was used to calculate proportions of NADCs. We abstracted medical records to obtain demographic and clinical profiles and HIV status information for 1127 patients diagnosed or treated during 2010-2014. Trends in numbers and proportions of NADCs were analyzed using Joinpoint regression. Characteristics of NADC patients were analyzed using multinomial logistic regression. RESULTS: NADCs diagnosed at ORCI increased by 33.8% from 2002 to 2014 while the proportion of NADCs relative to all cancers significantly decreased from 6.8% in 2002 to 5.6% in 2014 (APC = -2.74%). Numbers and proportions of lung and liver cancers increased compared to all cancer diagnoses from 2002 to 2014. The number of head and neck cancers increased while decreasing proportionally compared to all cancer diagnoses from 2002 to 2014. Among patients with pathologically confirmed NADCs between 2010 and 2014, HIV prevalence showed a non-statistically significant decrease from 8.1 to 7.1% (APC = -3.77%). CONCLUSIONS: Absolute numbers of lung, liver, and head and neck cancers increased at ORCI by 1/3 since 2002. Improving survivorship of HIV patients and varying immunodeficiency status may have contributed to the increasing number of NADCs. Total cancer diagnoses nearly doubled during this period, leading to a smaller relative proportion of NADCs diagnosed in 2014 compared to 2002. Late- stage diagnosis and short survival of NADCs included this study may explain possible underestimation and smaller increase in proportion of these particular NADCs compared to other NADCs studied in Tanzania. The slight decrease in proportion of HIV-positive NADC patients during 2010-2014 may suggest increasing patient longevity and more effective HIV management in Tanzania.

PA32†Family centred health care: a palliative care approach to engage communities to address the burden of hiv in tanzania abstract.

BACKGROUND: Tanzania is one of the countries most devastated by HIV and AIDS in the sub Saharan Africa. The Government of Tanzania has called for a community participation to address the burden of HIV in Tanzania(1) however the uptake of this call has been minimal. This paper intends to describe the role of Palliative Medicine in engaging communities to address burden of HIV in Tanzania. AIM: We aim to improve health outcomes of HIV+ children by engaging families through utilisation of palliative care principles in a low resource setting Method Single child with recurrent illness, multiple social spiritual and psychological problems was purposely selected from a pool of HIV+ children attending a PASADA HIV clinic and was offered care through palliative care approach. An interdisciplinary team of health providers was formed, goals of care were identified and care plan developed. Family members empowered with knowledge and skills to live with a HIV+ child and assigned specific role to ensure the boy's physical, psychological and spiritual needs are met. Through retrospective chart review, clinical meetings, counselling sessions with the child, family and providers information was gathered to enrich our understanding of the process. RESULTS: Goals of care were met: cleared infections, tested for HIV, resumed school, and family unified. Hundreds of children benefited from the experience generated and expansion of the approach was governed by community engagement. CONCLUSION: Families when empowered have much potentials that can reverse sufferings due to diseases through application of Palliative Care Principles in practice. REFERENCE: Tanzania Commission for AIDS. 2008 Annual Report.