Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism.

Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol) is a biologically active natural product derived from Magnolia and has been shown to have excellent biological activities. This paper discusses research progress on the use of honokiol in the treatment of lung cancer, as studies have confirmed that honokiol can exert anti-lung-cancer effects through multiple pathways and multiple signaling pathways, such as inhibiting angiogenesis, affecting mitochondrial function and apoptosis, regulating of autophagy and epithelial-mesenchymal transition (EMT). In addition, honokiol combined with other chemotherapy drugs is also a way in which it can be applied.

Shape of concentration-response curves between long-term particulate matter exposure and morbidities of chronic bronchitis: a review of epidemiological evidence.

Numerous studies have assessed the concentration-response (C-R) relationships between long-term exposure to particulate matter (PM) and mortality from cardiopulmonary diseases, but few studies have evaluated the C-R relationships between PM exposure and morbidity of chronic respiratory diseases or their symptoms, and to date no systematic review has been published on the characteristics of the C-R curves between PM exposure and respiratory disease morbidity. Screening of all available studies in Medline identified ten studies with figures or scatter plots showing the C-R relationships between PM exposure and chronic bronchitis or chronic cough/phlegm. The C-R relationships showed ballistic 'S' shaped curves, linear in the low to moderate PM range and flattening out in the high PM range. Moreover, the shape and level of the C-R curves differed markedly between susceptible and nonsusceptible populations. New evidence from a prospective cohort study confirmed that the C-R relationship between PM reduction and beneficial effects on respiratory health may be due to the decreased incidence of respiratory symptoms and increased recovery in individuals with symptoms of bronchitis. Additional studies are needed to assess the C-R relationships between different PM contents and chronic health parameters, especially in geographic areas with high PM pollution and in more susceptible populations. Evidence from prospective cohort studies in developing countries with areas of high PM pollution may help evaluate the burden of chronic respiratory disease attributable to PM pollution and air quality standards.

[Mortality trend on chronic obstructive pulmonary disease in Liaoning province, 1984-2010].

OBJECTIVE: To evaluate the mortality trend of chronic obstructive pulmonary disease (COPD) among residents in Liaoning province during the period of 1984-2010. METHODS: The cut-points were ascertained by Monte Carlo Permutation test in COPD mortality trend lines of Poisson regression with Joinpoint Regression Program. The annual percent changes (APC) before and after the cut-points and the average annual percent change (AAPC) of COPD mortality were examined during the period. RESULTS: Significant declining trends on COPD mortality among the urban population during 1984-2010 and that of rural population during 1999-2009 were found. The standardized urban COPD mortality rate by Chinese population declined from 243.93 per 100 thousand in 1984 to 33.13 per 100 thousand in 2010. The urban 26 years AAPC was -5.8%. While the mortality in the rural population decreased from 251.33 per 100 thousand in 1999 to 102.25 per 100 thousand in 2009 in the same population. The rural 10 years' AAPC was -6.8%. The total trend of COPD mortality reduction was mainly resulted from the fast decline of bronchitis mortality. The AAPC of COPD mortality of the urban population was -9.0% and greater than that of the rural population (-6.8%) from 1999 to 2009. The urban population had a lower COPD mortality than that of the rural population. In urban area, males had a higher COPD mortality than females, however, in the rural area, males had a lower COPD mortality than the females. CONCLUSION: The COPD mortality among the residents of Liaoning province declined significantly from 1984 to 2010. Further studies are needed to confirm the viewpoint of WHO that the prevalence of COPD would have a continuous increasing trend in China.

[Decomposition of life expectancy at birth by age and causes of death among residents of Liaoning province, 1975 - 2005].

OBJECTIVE: To analyze the impact of mortality by age and causes of death on life expectancy at birth among residents of Liaoning province. METHODS: The study included mortality data of urban and rural residents in two periods (1973 - 1975 and 2004 - 2005). Both Abridged Life Table and Arriaga method were used to calculate and to decompose life expectancy changes by age and causes of death. RESULTS: From 1975 - 2005, the life expectancy increased by 4.68 years in urban residents and 4.91 for rural residents with a higher increment among females than males. Most part of the increase (76.27% and 82.81% for urban and rural male, 58.76% and 62.13% for urban and rural female) in life expectancy within the last 30 years could be explained by the decrease of mortality in the populations at age 0 - 4 and 55 - 74. Diseases related to respiratory system and infectious disease were contributing the most to the gap in life expectancy between the two periods. Mortality of heart disease was a negative contributor to the changes in life expectancy among both rural and urban residents while the mortalities of cerebro-vascular diseases and malignant tumors were the negative contributors for rural residents. CONCLUSION: The increase of life expectancy in the last 30 years was mainly resulted from the decrease of mortality on both respiratory and infectious diseases. Control of chronic diseases is the key point to increase the life expectancy among the residents of Liaoning province.