Validation of an Inhaled Therapy Beliefs Questionnaire in Patients with Chronic Obstructive Pulmonary Disease.

Background: To carry out a validation questionnaire that assesses beliefs about inhaled treatments in patients with chronic obstructive pulmonary disease (COPD), as knowing patients' beliefs could help to improve medication adherence and health outcomes. Methods: We evaluated data from 260 COPD patients from electronic medical record databases from five primary healthcare centers, in a descriptive, cross-sectional study with a sample size calculated for a 10-item questionnaire, with an estimated Cronbach's alpha of 0.70 and a 95% confidence level. Study participants were selected via systematic random sampling. Variables: Ten-item Inhaled Therapy Beliefs Questionnaire, CCTI-Questionnaire v.2.0, time for completion, age, sex, educational level, spirometry severity (GOLD criteria), exacerbations (previous year), characteristics of inhaled treatment, and smoking habit. A two-year follow-up in a subsample of 77 patients from one health center was utilized. The Morisky-Green test, pharmacy dispensing data, test-retest (kappa coefficient), and an exploratory analysis of the adherence-belief relationship (ji-squared) were measured. Results: The 10-item questionnaire showed good viability (3 min completion time) when performed face-to-face or telephonically; its psychometric properties were acceptable, with an internal consistency (Cronbach's alpha) score of 0.613. Three factors explained 47.58% of the total variance (p < 0.0001): use (factor 1), effects (factor 2), and objectives (factor 3) of inhalers. The two-year follow-up ultimately considered 58 out of the 77 patients (10 deceased, 4 unlocated, 2 mistakes, 2 no inhaled treatment, and 1 withdrawal). Non-adherence was 48.3% in terms of the Morisky-Green test; 31% in terms of pharmacy dispensing data; and 40.4% considering both methods. There was low test-retest reliability, indicated by items 4, 8, and 9 of the CCTI-Questionnaire (Kappa = 0.4, 0.26, and 0.34; p-value < 0.0001, 0.008, and 0.001, respectively). There was mild correlation between beliefs and adherence. Conclusions: The ten-item CCTI-Questionnaire v.2.0 demonstrated acceptable psychometric properties regarding feasibility, reliability, and content validity.

Alteration of the ankle brachial index, follow-up of patients at risk of peripheral arterial disease, a descriptive longitudinal study.

Background The objective of this study was to detect peripheral arterial disease (PAD) by measuring the ankle-brachial index (ABI) in patients attending medical offices in primary health care who presented a moderate or high risk on the risk scale of Framingham. Design longitudinal descriptive. Setting urban health center. Materials and methods Patients at risk of peripheral arterial disease of the lower limbs: diabetes mellitus (DM), cardiovascular disease (CVD), high cardiovascular risk (HCR) (SCORE>5%), and/or compatible symptoms. Consecutive sampling, n=136 (expected prevalence 8%, alpha 0.05, precision 0.95, projected losses 20%). Dependent variable: ankle-brachial index (ABI). Independent variables: hypertension (HBP), age, sex, CVD, DM, glycosylated hemoglobin (HbA1C), hyperlipidemia (HLP), LDL cholesterol (LDL), smoking, body mass index (BMI), pulses, treatment. Multivariate analysis: linear regression. Confidence level 95%. Results From a sample of 136 patients, 90 were male (66.2%) and 46 were female (33.8%), with a mean age of 72.2 years (in 2021), and a standard deviation (SD) of 7. The prevalence of abnormal ABI (ABI <0.9) was 11%, with a mean ABI of 0.7 (SD 0.18). The bivariate analysis showed a significant relationship between abnormal ABI and pulse palpation (p<0.0001). Excluding patients with ABI ≥ 1.4, in the multivariate analysis (coefficient of determination 0.977), the B coefficients and their 95% confidence intervals (CI) are as follows: age B=0.006, 95% CI (0.002-0.010) (p=0.003); diabetes B=0.289, 95% CI (0.1-0.479) (p=0.003); pulse palpation B= -0.199, 95% CI (-0.289- -0.11) (p<0.0001). Conclusions Doctor consultations in primary care are a favorable context for making an early diagnosis of PAD, by measuring the ABI. The performance of the ABI should be included as part of the annual examination for chronic patients who regularly attend consultations, particularly those with moderate or high cardiovascular risk. In this way, preventive measures could be intensified to prevent future cardiovascular complications in these patients. The predictors of ABI are age, diabetes, and palpation of pulses.

Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study.

BACKGROUND: Oleocanthal and oleacein are olive oil phenolic compounds with well known anti-inflammatory and anti-oxidant properties. The main evidence, however, is provided by experimental studies. Few human studies have examined the health benefits of olive oils rich in these biophenols. Our aim was to assess the health properties of rich oleocanthal and oleacein extra virgin olive oil (EVOO), compared to those of common olive oil (OO), in people with prediabetes and obesity. METHODS: Randomised, double-blind, crossover trial done in people aged 40-65 years with obesity (BMI 30-40 kg/m2) and prediabetes (HbA1c 5.7-6.4%). The intervention consisted in substituting for 1 month the oil used for food, both raw and cooked, by EVOO or OO. No changes in diet or physical activity were recommended. The primary outcome was the inflammatory status. Secondary outcomes were the oxidative status, body weight, glucose handling and lipid profile. An ANCOVA model adjusted for age, sex and treatment administration sequence was used for the statistical analysis. RESULTS: A total of 91 patients were enrolled (33 men and 58 women) and finished the trial. A decrease in interferon-γ was observed after EVOO treatment, reaching inter-treatment differences (P = 0.041). Total antioxidant status increased and lipid and organic peroxides decreased after EVOO treatment, the changes reaching significance compared to OO treatment (P < 0.05). Decreases in weight, BMI and blood glucose (p < 0.05) were found after treatment with EVOO and not with OO. CONCLUSIONS: Treatment with EVOO rich in oleocanthal and oleacein differentially improved oxidative and inflammatory status in people with obesity and prediabetes.

[The effect of a falls prevention program in elderly people in primary health care. What does Tai Chi practice provide?] / Efecto de un programa de prevención de caídas en personas mayores en atención primaria. ¿Qué aporta la práctica de Tai Chi?

OBJECTIVE: Falls in the elderly are a major health problem. There are multiple experiences of intervention in primary care. Aim: To evaluate the impact of a multifactorial intervention in the prevention of falls in elderly people. To compare the differential effect of the practice of Tai Chi. METHODS: Non-randomized before-after quasi-experimental design in an urban health center between the years 2014-2017. The study population was those over 65 years old with a high risk of falls. The intervention consisted of an individual assessment of risk factors: sensory problems, balance, orthostatic hypotension, treatments (psychotropic drugs, hypotensive drugs), barriers, technical aids. It was intervened in its correction. Tai Chi group participation is proposed. The dependent variables (baseline and year measurements) were Barthel, Unipodal Station Test (TEU), number of falls per year, Anxiety/Depression Goldberg Scale (EADG), number of medical consultations per year, walking aids, Daily Dose Defined of analgesics (DDD)/ year. The before-after analysis was performed using the Chi2 and T Student statistics for paired samples. RESULTS: A total of 93 patients participated with an average age of 76+06,65, 84.9% women. Falls/year baseline 1.65 + 0.24; no significant differences between groups with or without Tai Chi in any baseline variable. At one year, average reduction of falls/year 0.53 (IC95% 0,07-0,99) (p=0.023), EADG anxiety 1.4±0.33 points (p<0.0001), EAGD depression 0.73±0.26 points (p=0.007). 44 patients practiced Tai Chi; finding: reduction of 1.88 (IC95% 0.90-2.80) points (p<0.0001) in EADG anxiety and 0.86 points (IC95% 0.12-1.60) (p=0.024) in EADG depression; 30.9% of patients abandoned technical aids (p<0.0001); 11% started psychotropic drugs. 49 patients did not practice Tai Chi; of them: EADG anxiety reduction of 1,020 points (IC95% 0.07-1.96) (p=0.035); 41.2% of patients initiated psychotropic drugs (p=0.001); none of the patients abandoned technical aids and 14.3% started them (p<0.001). CONCLUSIONS: The intervention reduced the number of falls, anxiety, the use of psychotropic drugs, depression, and the use of walking aids, with differential benefit of Tai Chi in these last three aspects.

OBJETIVO: Las caídas en las personas mayores son un problema de salud de primer orden. Existen múltiples experiencias de intervención en atención primaria. El objetivo de este trabajo fue evaluar el impacto de una intervención multifactorial en prevención de caídas en personas mayores y comparar el efecto diferencial de practicar Tai Chi. METODOS: Diseño cuasiexperimental antes-después no aleatorizado en un centro de salud urbano entre los años 2014-2017. La población de estudio fueron los mayores de 65 años con alto riesgo de caídas. La intervención consistió en una valoración individual de factores de riesgo: problemas sensoriales, equilibrio, hipotensión ortostática, tratamientos (psicofármacos, hipotensores), barreras arquitectónicas, ayudas técnicas. Se intervino en su corrección. Se propone la participación en grupo de Tai Chi. Las variables dependientes (mediciones basal y al año) fueron: Índice de Barthel, Test Estación Unipodal (TEU), número de caídas/año, Escala Ansiedad/Depresión de Goldberg (EADG), número de consultas médicas/año, uso de ayudas para la marcha, Dosis Diaria Definida(DDD) analgésicos/año. Se realizó el análisis antes-después utilizando Chi2 y T Student para muestras apareadas. RESULTADOS: Participaron un total de 93 pacientes, con una edad media de 76±6,65 años y un 84,90% mujeres. Número de Caídas/año basal 1,65±0,24; sin diferencias significativas entre grupos con/sin Tai Chi en ninguna variable inicial. Al año, reducción media de caídas/año a 0,53 (IC95% 0,07-0,99) (p=0.023), EADG ansiedad 1,40±0,33 puntos(p<0,0001), EADG depresión 0,73±0,26 puntos (p=0.007). Practicaron Tai Chi 44 pacientes, encontrándose: reducción de 1,88 (IC95% 0,90-2,80) puntos (p<0.0001) en EADG ansiedad y 0,86 puntos (IC95% 0,12-1,60) (p=0,024) en EADG depresión; 30,90% de pacientes abandonaron ayudas técnicas (p<0.0001); iniciaron psicofármacos 11%. No practicaron Tai Chi 49 pacientes, en ellos se redujo 1,02 puntos la EADG ansiedad (IC95% 0,07-1,96) (p=0,035); 41,20% de pacientes iniciaron psicofármacos (p=0,001); ningún paciente abandonó ayudas técnicas y 14,30% las iniciaron (p<0,001). CONCLUSIONES: La intervención redujo las caídas, la ansiedad, el uso de los psicofármacos, la depresión, y el uso de ayudas para la marcha, con beneficio diferencial del Tai Chi en estos tres últimos aspectos.

[Polio and post-polio syndrome, viewed by patients and health professionals in primary care]. / Polio y postpolio. Visión de pacientes y profesionales en atención primaria.

OBJECTIVE: Polio affects the quality of life of those who have suffered from it and causes health problems including the post-polio syndrome. The main goals of this work were to know the patients perspective of how they have been affected by the disease and establish the knowledge of post-polio syndrome among patients and primary health care professionals. METHODS: Interpretive qualitative research based on the Grounded Theory carried out in two health-care centers in the city of Malaga, one of them with care-rural clinics. Four focal groups were established with the participation of thirteen patients and two focus groups with twenty-six professional participants. Intentional sampling is performed until saturation. The analysis follows an inductive strategy using the Atlas Ti5.2 software. RESULTS: The people affected by polio reports their personal histories of suffering counteracted by strong family support and an active coping attitude, marked by great effort exertion, willpower and endurance. These people made a positive assessment of their lives minimising the limitations. They presented compatible symptoms with post-polio syndrome, which remain unidentified due to the lack of knowledge of it among patients and health-care professionals. The health care provided was considered deficient due to several causes as for instance lack of involvement, communication problems. CONCLUSIONS: The day-to-day polio experience is focused on personal overcoming with major roles played by family support, difficult relationships with the healthcare system and lack of knowledge of the post-polio syndrome.

OBJETIVO: La polio afecta a la calidad de vida de las personas que la han padecido y ocasiona problemas de salud entre los que se encuentra el síndrome postpolio. Los objetivos de este estudio fueron conocer la perspectiva de pacientes sobre cómo les ha afectado la enfermedad y describir el conocimiento sobre el síndrome postpolio de pacientes y profesionales de atención primaria. METODOS: Investigación cualitativa interpretativa basada en la Teoría Fundamentada, realizada en dos centros de salud de la ciudad de Málaga, uno de ellos con consultorios rurales. Se realizaron cuatro grupos focales con participación de trece pacientes y dos grupos focales con veintiséis profesionales participantes. Muestreo intencional hasta saturación. El análisis siguió una estrategia inductiva con ayuda del programa Atlas Ti 5.2. RESULTADOS: Los pacientes relataron una historia personal de sufrimiento, contrarrestada por un fuerte apoyo familiar y afrontamiento activo (categoría central), marcado por el sobreesfuerzo, la superación y una alta resiliencia. Realizaron una valoración positiva de sus vi- das, minimizando las limitaciones. Presentaron síntomas compatibles con el síndrome postpolio, no identificado por el gran desconocimiento de pacientes y profesionales. La atención sanitaria fue considerada deficitaria (falta de implicación y problemas de comunicación). CONCLUSIONES: La vivencia de la polio está centrada en la superación personal, con gran relevancia del apoyo familiar, las difíciles relaciones con el sistema sanitario y el desconocimiento del síndrome postpolio.

[Coming out of the whirlwind of abuse. Qualitative research on gender violence]. / El torbellino de la violencia. Relatos biográficos de mujeres que sufren maltrato.

OBJECTIVES: To analyse the experience from the point of view of women who have suffered domestic violence. To identify factors related to continuing or resolving the problem. DESIGN: Qualitative interpretative research from a phenomenological perspective. POPULATION SAMPLE: Women, detected in primary care, who have suffered domestic violence and have recognised the problem, and who accepted to participate in this research. MULTICENTRE STUDY: Six health centres in the city of Malaga. METHODS AND TECHNIQUES: The technique used is the biographical narration using individual open interviews between social workers and women. This narration was tape-recorded and verbatim transcribed to written text. Grounded theory. Qualitative analysis was made with ATLAS-TI 5.2. OUTCOMES: A total of 35 narrations were analysed. The abuse situation was described as "whirl-wind" metaphor (blindness-isolation-helplessness-suffering-destiny-dependence-fantasies -about love, protection, happiness, change- and vicious circles). Enduring experience is reported to be related to several factors: inculcated gender values, family-ideal, uncertainty, annulment, personal failure sensation, love, support defects, self-image, children protection, multiple fears and material aspects. They identified two types of "exit": passive and active with different mechanisms and repercussions. Exit experience is related to: limit situations, children intervention, family ideal attempts, and fear-loss. Leaving is a transitional process or "pathway". Institutional support is not always guaranteed and emotional support is better evaluated than a legal one. CONCLUSIONS: Enduring and coming out are reported as two qualitatively different states, which involve many cultural and personal factors. There is a gap between these two states with a process that varies depending on the involvement of the women in decision-making.