Assuntos
Alelos , Conexinas/genética , Transtornos da Audição/genética , Mutação , Regiões Promotoras Genéticas , Conexina 26 , HumanosRESUMO
The aim of the study was to find the correlation between specific risk factors for hearing impairment as well as between risk factors and TEOAE screening results in neonates at risk for hearing impairment. Seventy-one newborns at risk for hearing impairment have been included in the study. Strong correlations between specific risk factors were found. Investigation of the relationship between specific risk factors and TEOAE signal-to-noise ratio (SNR) showed that in children with genetic risk factors, TORCH (toxoplasmosis, rubella, CMV, herpes virus, others) infections and in those treated with ototoxic drugs, the values of SNRs were significantly lower than in children at risk who did not present those factors. In case of hyperbilirubinaemic children the values of SNR were significantly higher than in the controls. In our opinion these relationships may be partially explained by the positive predictive values of these risk factors, but other intrinsic factors may also be involved.
Assuntos
Guias como Assunto , Transtornos da Audição/diagnóstico , Transtornos da Audição/epidemiologia , Emissões Otoacústicas Espontâneas/fisiologia , Transtornos da Audição/etiologia , Humanos , Recém-Nascido , Valor Preditivo dos Testes , Fatores de RiscoRESUMO
Neonatal hearing screening is becoming a standard of care in increasing number of hospitals and outpatient departments in Poland. A project of central data collecting system applicable to a neonatal hearing screening programme has been elaborated as a preparation to introducing a countrywide screening programme. The data collecting system will be based on the currently existing central system for the registration of neonatal screening tests for metabolic diseases. Data on risk factors for hearing loss and hearing screening test results will be collected. A central data collecting system for a neonatal hearing screening programme will increase the efficiency of the screening programme and facilitate epidemiological studies.
Assuntos
Coleta de Dados , Transtornos da Audição/diagnóstico , Transtornos da Audição/epidemiologia , Triagem Neonatal , Humanos , Recém-Nascido , Polônia/epidemiologia , Avaliação de Programas e Projetos de SaúdeRESUMO
About 27% of malignant tumors in children is located in the head and neck. Besides primary solid tumors, lymph node metastases as well as signs of systemic diseases of the lymphatic tissue are often found in this region. The latter are the most common childhood malignancies. Among primary solid malignant tumors in this region neoplasms of the soft tissues are frequency found. Their prevalence comes next to the tumors of the central nervous system and the orbit. Rhabdomyosarcoma (RMS) represents 50% of cases in this group. Malignant neoplasms originating from epithelial and bone tissue occur rarely in children. The evolution of triple therapy, combining surgery with irradiation and chemotherapy has produced and improvement in prolonged survival rates in these children.
Assuntos
Neoplasias de Cabeça e Pescoço/epidemiologia , Criança , Terapia Combinada , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Prevalência , Taxa de SobrevidaRESUMO
4 cases of malignant tumors of the head and neck diagnosed in our department in 1983-1987 are presented. They are: rhabdomyosarcoma (RMS) of the nose and the ethmoid sinuses, RMS of the nasal vestibulum, nasopharyngeal lymphoma malignum. Diagnostic difficulties were met by the histopathological evaluation of the tumors specimens, but the applied treatment was effective. There are no signs of recurrence during the observation period of 4-8 years.