RESUMO
The levels of plasma fibronectin (FN) were investigated in patients during heart surgery using artificial circulation. Plasma FN levels were assessed by electroimmunoassay (rocket immunoelectrophoresis) and bioassay (aggregation of gelatin-coated microparticles). The application of gelatinol in hemodilution++ composition led to the depletion of bioactive Fn from 140 to 0 micrograms/ml, whereas immunoreactive Fn levels were slightly elevated. The in vitro experiments have shown that gelatinol inhibits the aggregation of gelatinol-coated microparticles and chemiluminiscence of neutrophils, stimulated by gelatin-coated particles. Gelatinol elimination from hemodilution++ composition resulted in the reduction of postoperative mortality and accelerated tissue reparation.
Assuntos
Circulação Extracorpórea , Fibronectinas/sangue , Gelatina/administração & dosagem , Cardiopatias Congênitas/cirurgia , Doenças das Valvas Cardíacas/cirurgia , Hemodiluição , Valva Aórtica/cirurgia , Fibronectinas/antagonistas & inibidores , Cardiopatias Congênitas/sangue , Doenças das Valvas Cardíacas/sangue , Humanos , Técnicas In Vitro , Cuidados Intraoperatórios , Valva Mitral/cirurgiaRESUMO
Under consideration is the experience with 64 operations of palliative areflux gastro-enteroanastomoses for inoperable cancer of distal portion of the stomach. The absence of lethal issues and such complications as suture incompetency at the anastomosis site, peritonitis, postoperative reflux-gastritis are felt by the authors to be due to the advantages of this operative technic. In 39 of 64 patients palliative surgery was soon followed by chemotherapy. The longer survival from 4--6 months to 11 months was noted only after palliative operations.