Formation of hen egg white lysozyme derived amyloid-based hydrogels using different gelation agents: A potential tool for drug delivery.

Amyloids are highly stable protein fibrillar aggregates that get deposited in various parts of our body and cause detrimental diseases. But in nature, the presence of functional amyloids is also noted in bacteria that help them by forming hyphae, biofilm, protein reservoirs, signalling messengers, etc. Keeping this perspective in mind, the idea behind this research was to develop functional amyloids in the form of hydrogel and analyse its potential in the biomedical sector as a drug-delivery tool. The synthesis and characterisation of three types of amyloid-based hydrogels have been reported in this work. Hen Egg-White Lysozyme (HEWL) protein was chosen as the principal ingredient as it is extensively used as a standard protein for studying amyloidogenesis and has inherent antibacterial properties. Comparative studies of different hydrogel properties exhibited variations in the hydrogels based on compositional differences in them. Finally, a drug release assay was done on the synthesized hydrogels to explore their potential as drug delivery tools.

A Comprehensive Review on Inorganic Nanoparticles as Effective Modulators of Amyloidogenesis.

Many degenerative disorders have started to develop as a result of the deposition of insoluble protein fibrillar clumps known as amyloid. This deposition mostly limits normal cellular function and signaling. This build-up of amyloid in vivo results in a variety of illnesses in the body, including type 2 diabetes, several neurodegenerative diseases (such as Alzheimer's disease and spongiform encephalopathy), and Alzheimer's disease. Growing interest has been demonstrated in nanoparticles as a potential treatments for amyloidosis throughout the past few decades. Inorganic nanoparticles are one of them and have also been in substantial research as a potential anti-amyloid drug. Inorganic nanoparticles have emerged as a good study candidates because of their nano size, distinctive physical characteristics, and capacity to traverse the blood-brain barrier. In the current review, we have focused on the effects of different types of inorganic nanoparticles on amyloidogenesis and attempted to understand their underlying mechanism of action.