1.
Cell
; 187(3): 517-520, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38306978
RESUMO
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets." Overcoming these challenges will amplify the impact of structural biology on drug discovery.