Clinical relevance of cagA and vacA and association with mucosal findings in Helicobacter pylori-infected individuals from Chennai, South India.

Helicobacter pylori is associated with a spectrum of severe gastrointestinal conditions. In this study, an attempt was made to correlate endoscopic mucosal patterns with H. pylori infection and examine the pathogenic potential of the strains. Among the 147 dyspeptic individuals studied, 42.2% were H. pylori infected. Association of H. pylori with type 3 and 4 mucosal patterns (P = 0.001) and intestinal metaplasia (P = 0.012) was seen. vacA was associated with histological (P = 0.014) and endoscopy findings (P = 0.009). Association of mucosal patterns with H. pylori infection could be useful for clinicians to decide on the need for eradication therapy.

pH Metric, Spectroscopic and Thermodynamic Study of Complexation Behavior of 2-aminobenzothiazole with Ni (II) in Presence of Amino Acids.

The complexation of 2-aminobenzothiazole (2abt) [A] with Ni(II) in presence of amino acids viz., glycine (gly), L-alanine (ala), L-valine (val) and L-phenylalanine (pal) [B] in 50% (v/v) water-ethanol mixture containing NaClO4 (0.15 M) has been studied by pH metrically at various temperatures (300, 310, 320 and 330 ± 0.1 K). Mixed ligand complexes of types NiAB and NiAB2 were observed and their stability constants were determined. The stabilization of mixed ligand complexes over binary analogues has been derived from Δ log K, log X' and log X values. The thermodynamic parameters ΔG, ΔH and ΔS were derived from the temperature dependence of the equilibrium constants. The complexation behavior has also been studied by means of electronic spectra. On the basis of stability constants and electronic spectra, it is revealed that the mixed ligand complexes have six-coordinated octahedral structure. The binary and mixed ligand complexes were screened for their microbial activities in vitro on common bacteria, fungi and yeast. The DNA cleaving activities were studied by electrophoresis method.

Spectral, XRD, SEM and biological activities of transition metal complexes of polydentate ligands containing thiazole moiety.

Metal complexes of o-vanillidene-2-aminobenzothiazole have been prepared and characterized by elemental and spectral (vibrational, electronic, 1H NMR and EPR) data as well as magnetic susceptibility measurements and thermo gravimetric analysis (TG/DTA). The low molar conductance values reveal the non-electrolytic nature of these complexes. The elemental analysis suggests that the stoichiometry to be 1:2 (metal:ligand). Magnetic susceptibility data coupled with electronic spectra suggest that two ligands coordinate to each metal atom by phenolic oxygen and imino nitrogen to form high spin octahedral complex with Co(II), Mn(II) and Ni(II). The fifth and sixth position of metal ion is satisfied with water molecules. The thermal behaviour (TG/DTA) of the synthesised complexes shows that the complexes loss water molecules in the first step followed by decomposition of the ligand. Spin Hamiltonian parameters predict a distorted tetrahedral geometry for the copper complex. XRD and SEM analysis provide the crystalline nature and the morphology of the metal complexes. The in vitro biological activity of the metal chelates is tested against the Gram positive bacteria (Bacillus amyloliquifacians) and gram negative bacteria (Pseudomonas species), fungus (Aspergillus niger) and yeast (Sacchromyces cereviaceae). Most of the metal chelates exhibited higher biological activities.