Environmental threatening concern and efficient removal of pharmaceutically active compounds using metal-organic frameworks as adsorbents.

An alarming number of contaminants of emerging concern, including active residues from pharmaceuticals and personal care products (PPCPs), are increasingly being introduced in water systems and environmental matrices due to unavoidable outcomes of modern-day lifestyle. Most of the PPCPs based contaminants are not completely eliminated during the currently used water/wastewater treatment processes. Therefore, highly selective and significant removal of PPCPs from environmental matrices remains a scientific challenge. In recent years, a wide range of metal-organic frameworks (MOFs) and MOF-based nanocomposites have been designed and envisioned for environmental remediation applications. MOF-derived novel cues had shown an adsorptive capability for the extraction and removal of an array of trace constituents in environmental samples. Noteworthy features such as substantial surface area, size, dispersibility, tunable structure, and repeated use capability provide MOFs-derived platform a superiority over in-practice conventional adsorptive materials. This review provides a comprehensive evaluation of the efficient removal or mitigation of various categories of PPCPs by diverse types of MOF-derived adsorbents with suitable examples. The growing research investigations in this direction paves the way for designing more efficient porous nanomaterials that would be useful for the elimination of PPCPs, and separation perspectives.

Rhodol-conjugated polymersome sensor for visual and highly-sensitive detection of hydrazine in aqueous media.

Hydrazine is a hazardous environmental pollutant, which contaminates land, air and water posturing a severe risk to human health. For the first-hand estimation, a qualitative approach (colorimetric) for recognition of hydrazine could suffice. However, for accurate measurement, under the threshold limit value (TLV), a quantitative technique is desired. We report the polymersome-based sensor for visual detection and quantification of hydrazine in water. The rhodol-functionalized amphiphilic hyperbranched multiarm copolymer (HSP-RDL) was self-assembled into vesicles. The HSP-RDL vesicle probe exhibited high sensitivity and selectivity for hydrazine recognition in presence of various competitive species such as cations, anions, and neutral species. The fast responsive pink color change from colorless could be visualized with naked eye due to spirolactone ring opening by hydrazinolysis triggered strong fluorescence emission. The vesicle probe could detect hydrazine in water with a limit of detection (LOD) value of 2 nM (0.0652 ppb), which is lower than TLV (10 ppb) given by USEPA (United States Environmental Protection Agency). Furthermore, the vesicle probe could quantify hydrazine (recovery ≥ 99 %) in a wastewater sample collected from Huangpu river. The membrane-permeable characteristics of HSP-RDL led hydrazine detection in live cells through confocal fluorescence microscopy.

TiO2/SiO2 decorated carbon nanostructured materials as a multifunctional platform for emerging pollutants removal.

Aquatic ecosystem contaminated with hazardous pollutants has become a high priority global concern leading to serious economic and environmental damage. Among various treatment approaches, carbon nanostructured materials have received particular interest as a novel platform for emerging pollutants removal owing to their unique chemical and electrical properties, biocompatibility, high scalability, and infinite functionalization possibility with an array of inorganic nanomaterials and bio-molecules. Within this framework, carbon nanotubes (CNTs) are widely used due to their hollow and layered structure and availability of large specific surface area for the incoming contaminants. Carbon nanotubes can be used either as single-walled, multi-walled, or functionalized nanoconstructs. TiO2/SiO2-functionalized CNTs are among the most promising heterogeneous photocatalytic candidates for the degradation of a range of organic compounds, heavy metals reduction, and selective oxidative reactions. Herein, we reviewed recent development in the application of TiO2 and SiO2 functionalized nanostructured carbon materials as potential environmental candidates. After a brief overview of synthesis and properties of CNTs, we explicitly discussed the potential applications of TiO2/SiO2 functionalized CNTs for the remediation of a variety of environmentally-related pollutants of high concern, including synthetic dyes or dye-based hazardous waste effluents, as polycyclic aromatic hydrocarbons (PAHs), pharmaceutically active compounds, pesticides, toxic heavy elements, remediation of metal-contaminated soil, and miscellaneous organic contaminants. The work is wrapped up by giving information on current challenges and recommended guidelines about future research in the field bearing in mind the conclusions of the current review.

Aqueous monitoring of toxic mercury through a rhodamine-based fluorescent sensor.

Mercury is a toxic heavy element, which contaminates air, land, and water, thus posing environment and human health-related threats to the ecological system. Considering the adverse ecological effects, there is an urgent need to design and develop strategic tools to detect a broader spectrum of toxic elements in different environments. The development of point-of-care tools, e.g., sensor-based devices offers a noteworthy solution to detect and monitor real-time generation or release of environmentally-related toxic elements from different sectors, even with or without partial treatments. For a first-hand estimate, a qualitative method (colorimetric) for detection of mercury could suffice. Benefiting from the colorimetric recognition methodology, herein, we developed a new system (2-(5-bromothiazol-2-yl)-3',6'-bis(diethylamino)spiro[isoindoline-1,9' xanthen]-3-one) for the detection of mercury ions. The newly developed chemical sensor is composed of a fluorescent part (rhodamine b) and a binding site (2-amino-5-bromothiazole). A highly selective and sensitive response accompanied by visual color change (colorless to pink) towards Hg²âº was observed among miscellaneous metal cations. This colorimetric change confirmed that the coordination complex exists as spirocyclic ring opened derivative of rhodamine moiety. Furthermore, the binding affinity and detection limit was also calculated from the absorbance and emission data. The calculated values are in the order of 4.72 × 104 M⁻¹ and 6.9 µM, respectively. In addition, the results reveal that the complex between the chemical sensor (S) and Hg²âº is reversible in the presence of ethylenediaminetetraacetate (EDTA²â»). Finally, the newly developed sensor S was employed to detect Hg²âº in the wastewater. The fluorescence intensity was measured at 583 nm with S followed by spiking with Hg²âº at different concentrations and related linearly. In summary, taken together all the properties suggest that the newly developed sensor might display great potential in the field of environmental monitoring of toxic elements.

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release.

In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Both external/internal and even dual/multi-responsive behavior of polymeric carriers is considered an essential element of engineering so-called 'smart' DDS, which controls the effective and efficient dose loading, sustained release, individual variability, and targeted permeability in a sophisticated manner. So far, an array of DDS has been proposed, developed, and implemented. For instance, redox, pH, temperature, photo/light, magnetic, ultrasound, and electrical responsive DDS and/or all in all dual/dual/multi-responsive DDS (combination or two or more from any of the above). Despite the massive advancement in DDS arena, there are still many challenging concerns that remain to be addressed to cover the research gap. In this context, herein, an effort has been made to highlight those concerning issues to cover up the literature gap. Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings.

Hazardous contaminants in the environment and their laccase-assisted degradation - A review.

In recent years, owing to the serious ecological risks and human health-related adverse effects, the wide occurrence of hazardous contaminants along with their potential to enter the environment have gained great public concerns. In this context, significant actions are urgently required to tackle the ignorance and inefficient monitoring/removal of emerging/(re)-emerging contaminants (ECs) in the environment from different routes of concerns, i.e., industrial waste, pharmaceutical, personal care products (PCPs), toxic effluents, etc. Laccases are multinuclear copper-containing oxidoreductases and can carry out one electron oxidation of a broad spectrum of environmentally related contaminants. In biotechnology, this group of versatile enzymes is known as a green catalyst/green tool with enormous potentialities to tackle ECs of high concern. In this review, we endeavored to present up-to-date literature concerning the potential use of immobilized laccases for the degradation and remediation of various types of environmental pollutants present in the environment. Both, pristine and immobilized, laccases have shown great capacity to oxidative degradation and mineralization of endocrine disrupting chemicals (EDs) in batch treatment processes as well as in large-scale continuous reactors. These properties make laccase as particularly attractive biocatalysts in environmental remediation processes, and their use might be advantageous over the conventional treatments. This review summarizes the most significant recent advances in the use of laccases and their future perspectives in environmental biotechnology.

Environmentally-related contaminants of high concern: Potential sources and analytical modalities for detection, quantification, and treatment.

In recent years, emerging contaminants (ECs) of high concern are broadly distributed throughout the environmental matrices because of various industrial practices and anthropogenic inputs, i.e., human-made activities. With ever increasing scientific knowledge, technological advancement, socio-economic awareness, people are now more concern about the widespread distribution of environmentally related ECs of high concern. As, ECs possess serious ecological threats and potential risks to human health and aquatic life, even at minor concentrations. The controlled or uncontrolled discharge and long-term persistence of ECs that includes micro-pollutants, endocrine disruptors (EDs), pesticides, pharmaceuticals, hormones, toxins, and industrially-related synthetic dyes and dyes-containing hazardous pollutants, etc. pose a significant challenge to policy regulators, engineers, and scientific community. The conventional treatment technologies are proved ineffective for the complete elimination and removal of an array of contaminants of emerging environmental concern in various biological and environmental samples. In order to overcome the aforementioned ecological threats, tremendous research efforts have been made to boost the efficiency of remediation techniques or develop new modalities to detect, quantify and treat the samples efficiently. The boom in biotechnology and environmental engineering offers potential opportunities to develop advanced and innovative remediation techniques in the field of water treatment. This review discusses the environmental and health hazards associated with a widespread distribution of micro-pollutants, pesticides, pharmaceuticals, hormones, and industrially-related synthetic dyes and dyes-containing hazardous pollutants, etc. in the water bodies, i.e., surface water, groundwater, and industrial wastewater streams. Life-cycle distribution of emerging (micro)-pollutants with suitable examples from various industrial sources viewpoints is also discussed. The later part of the review focuses on innovative and cost-effective remediation (removal) approaches from phase-changing treatment technologies for these ECs of high concern.

Catalytic potential of bio-synthesized silver nanoparticles using Convolvulus arvensis extract for the degradation of environmental pollutants.

Herein, we reported a facile, green and environmental friendlier biosynthesis of silver nanoparticles using the Convolvulus arvensis extract. The influences of various physicochemical factors such as the concentration of the plant extract, reaction time, and different pH levels were investigated by UV-Vis spectroscopy. The UV-Visible absorption spectrum of biogenic silver nanoparticles at λmax around ~400 nm suggested the biosynthesis of silver nanoparticles. Fourier transform infrared spectroscopy was employed to confirm the chemical transformation and role of various phyto-reductants in the conversion of Ag+ to Ag0. The surface morphology, topography, and elemental composition were analyzed by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. X-ray diffraction corroborated the face-centered cubic crystalline structure. The dynamic light scattering and zeta potential demonstrate the size distribution (90.9 nm) and surface charge (-18.5). Finally, the newly developed C. arvensis based silver nanoparticles were exploited as a catalyst for the catalytic reduction of azo dyes in the presence of NaBH4 as a reducing agent, and reducing the activity of C. arvensis based silver nanoparticles was evaluated by a decrease in optical density using UV-Vis spectrophotometer. The nanoparticles developed herein displayed potential efficiency for the degradation of all the tested dye pollutants. Conclusively, plant-based synthesis of nanoparticles provides an environmentally-responsive option for the reduction of highly environmental-polluted organic compounds including toxic azo dyes as compared to chemical and physical methods.

Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements-A Review.

In recent decades, environmental pollution has emerged as a core issue, around the globe, rendering it of fundamental concern to eco-toxicologists, environmental biologists, eco-chemists, pathologists, and researchers from other fields. The dissolution of polluting agents is a leading cause of environmental pollution of all key spheres including the hydrosphere, lithosphere, and biosphere, among others. The widespread occurrence of various pollutants including toxic heavy metals and other emerging hazardous contaminants is a serious concern. With increasing scientific knowledge, socioeconomic awareness, human health problems, and ecological apprehensions, people are more concerned about adverse health outcomes. Against this background, several removal methods have been proposed and implemented with the aim of addressing environmental pollution and sustainable and eco-friendly development. Among them, the biosorption of pollutants using naturally inspired sources, e.g., marine algae, has considerable advantages. In the past few years, marine algae have been extensively studied due to their natural origin, overall cost-effective ratio, and effectiveness against a broader pollutant range; thus, they are considered a potential alternative to the conventional methods used for environmental decontamination. Herein, an effort has been made to highlight the importance of marine algae as naturally inspired biosorbents and their role in biosorption. Biosorption mechanisms and factors affecting biosorption activities are also discussed in this review. The utilization of marine algae as a biosorbent for the removal of numerous potentially toxic elements has also been reviewed.

Fluorescent sensor based models for the detection of environmentally-related toxic heavy metals.

The quest for industrial and biotechnological revolution has been contributed in increasing environmental contamination issues, worldwide. The controlled or uncontrolled release of hazardous pollutants from various industrial sectors is one of the key problems facing humanity. Among them, adverse influences of lead, cadmium, and mercury on human health are well known to cause many disorders like reproductive, neurological, endocrine system, and cardiovascular, etc. Besides their presence at lower concentrations, most of these toxic heavy metals are posing noteworthy toxicological concerns. In this context, notable efforts from various regulatory authorities, the increase in the concentration of these toxic heavy metals in the environment is of serious concern, so real-time monitoring is urgently required. This necessitates the exploration for novel and efficient probes for recognition of these toxic agents. Among various methodologies adopted for tailoring such probes, generally the methodologies, in which changes associated with spectral properties, are preferred for the deceptive ease in the recognition process. Accordingly, a promising modality has emerged in the form of radiometric and colorimetric monitoring of these toxic agents. Herein, we review fluorescent sensor based models and their potentialities to address the detection fate of hazardous pollutants for a cleaner environment. Second, recent advances regarding small molecule and rhodamine-based fluorescent sensors, radiometric and colorimetric probes are discussed. The information is also given on the photoinduced electron transfer (PET) mechanism, chelation enhancement fluorescence (CHEF) effect and spirocyclic ring opening mechanism.