Adapting multilingual vision language transformers for low-resource Urdu optical character recognition (OCR).

In the realm of digitizing written content, the challenges posed by low-resource languages are noteworthy. These languages, often lacking in comprehensive linguistic resources, require specialized attention to develop robust systems for accurate optical character recognition (OCR). This article addresses the significance of focusing on such languages and introduces ViLanOCR, an innovative bilingual OCR system tailored for Urdu and English. Unlike existing systems, which struggle with the intricacies of low-resource languages, ViLanOCR leverages advanced multilingual transformer-based language models to achieve superior performances. The proposed approach is evaluated using the character error rate (CER) metric and achieves state-of-the-art results on the Urdu UHWR dataset, with a CER of 1.1%. The experimental results demonstrate the effectiveness of the proposed approach, surpassing state of the-art baselines in Urdu handwriting digitization.

Investigating Machine Learning Techniques for Predicting Risk of Asthma Exacerbations: A Systematic Review.

Asthma, a common chronic respiratory disease among children and adults, affects more than 200 million people worldwide and causes about 450,000 deaths each year. Machine learning is increasingly applied in healthcare to assist health practitioners in decision-making. In asthma management, machine learning excels in performing well-defined tasks, such as diagnosis, prediction, medication, and management. However, there remain uncertainties about how machine learning can be applied to predict asthma exacerbation. This study aimed to systematically review recent applications of machine learning techniques in predicting the risk of asthma attacks to assist asthma control and management. A total of 860 studies were initially identified from five databases. After the screening and full-text review, 20 studies were selected for inclusion in this review. The review considered recent studies published from January 2010 to February 2023. The 20 studies used machine learning techniques to support future asthma risk prediction by using various data sources such as clinical, medical, biological, and socio-demographic data sources, as well as environmental and meteorological data. While some studies considered prediction as a category, other studies predicted the probability of exacerbation. Only a group of studies applied prediction windows. The paper proposes a conceptual model to summarise how machine learning and available data sources can be leveraged to produce effective models for the early detection of asthma attacks. The review also generated a list of data sources that other researchers may use in similar work. Furthermore, we present opportunities for further research and the limitations of the preceding studies.

Efficacy of maize differing in particle size in low-density protein diets fed to broilers from day 1 to 21 of age.

1. This study evaluated the efficacy of maize differing in particle size in low-density protein diets on performance, the digestive tract and litter characteristics in broilers. Four dietary treatments; control commercial diet with a typical crude protein content 22.50% (CON); CON + 20% maize with particle size 350 µm (M350), crude protein 19.90%; CON + 20% maize with particle size 2600 µm (M2600), crude protein 19.90%); CON + 20% whole maize (WM), crude protein 19.90%, were fed ad libitum to broiler chicks up to 21 d of age.2. No differences in body weight gain, feed intake and FCR were found between the WM and CON. WM increased body weight gain compared to M350 and M2600. M350, M2600 and WM increased (p = 0.004) gizzard relative weight compared with CON on day 14. Both WM and M2600 reduced (p = 0.001) gastric isthmus diameter on d 14 and 21 compared with CON and M350.3. No differences were seen in mucosa for the Lamina propria and the extent of Tunica muscularis of gizzard on d 21 and ileum mucosal depth on d 14 between WM and CON diets. However, WM reduced villus-to-crypt ratio compared with CON on d 21. The M350 reduced (p < 0.05) gizzard digesta particle size compared with CON, M2600 and WM on d 14.4. Both WM and M350 decreased (p < 0.05) nitrogen excretion compared to birds fed CON. Feeding WM increased nitrogen efficiency compared with M350 and M2600 diets, but was similar to birds fed CON. Feeding M350, M2600 or WM decreased (p < 0.05) litter moisture and footpad dermatitis (FPD) scores compared with results from birds fed CON.5. Overall, diluting the protein level in broiler diets with whole maize appeared better than fine or coarse maize in terms of growth performance, digestive tract development, nitrogen excretion and litter parameters. This may lead to economic benefits by reducing grinding costs and dependence on rich protein resources contributing to sustainable meat production and food security.

Insights into the consequence of (Al-Zn) dual-doping on structural, morphological, and optoelectrical properties of CdO thin films.

The present study explores the structural, morphological, optical, and electrical properties of spray pyrolyzed (Al-Zn) dual-doped CdO thin films. The un-doped and (Al-Zn) dual-doped CdO thin films have been deposited on glass substrate using spray pyrolysis route at 325 °C. The physical properties of the doped samples were analyzed as a function of Zn concentration (2-5 mol%) with constant Al (3 mol%) concentration. XRD analysis confirms the successful incorporation of (Al-Zn) dual-doping into CdO crystal as well as the polycrystalline nature was evident. No phase transitions were apparent from XRD data while revealing the single cubic structure of all the samples. The surface morphology of the samples studied by SEM. It shows the formation of rock-shaped microstructure and the variation of grain size with doping concentrations. Optical analysis was done using UV-vis spectroscopy within the range of 300-1200 nm. Maximum value of transmittance was attained for 3% (Zn-Al)-doped CdO sample. The dual doping exhibits the broadening of band gap values (2.61-3.84 eV) whereas a decrease in extinction coefficient was noticed as a function of Zn doping concentration. Electrical analysis was done using the four-probe method and a high resistivity was seen for higher Zn concentration. Obtained results and precise comparison with some similar films suggested that 2% Zn and 3% Al co-doping can be a suitable candidate for optoelectronic devices.

Image synthesis of apparel stitching defects using deep convolutional generative adversarial networks.

In industrial manufacturing, the detection of stitching defects in fabric has become a pivotal stage in ensuring product quality. Deep learning-based fabric defect detection models have demonstrated remarkable accuracy, but they often require a vast amount of training data. Unfortunately, practical production lines typically lack a sufficient quantity of apparel stitching defect images due to limited research-industry collaboration and privacy concerns. To address this challenge, this study introduces an innovative approach based on DCGAN (Deep Convolutional Generative Adversarial Network), enabling the automatic generation of stitching defects in fabric. The evaluation encompasses both quantitative and qualitative assessments, supported by extensive comparative experiments. For validation of results, ten industrial experts marked 80% accuracy of the generated images. Moreover, Fréchet Inception Distance also inferred promising results. The outcomes, marked by high accuracy rate, underscore the effectiveness of proposed defect generation model. It demonstrates the ability to produce realistic stitching defective data, bridging the gap caused by data scarcity in practical industrial settings.

Depolymerized carrageenan expresses elicitor-like activity on Mentha arvensis L. under arsenic stress: Insights into arsenic resilience and monoterpene synthesis.

Heavy metals contaminate agricultural land by limiting the productivity of crops and making them or their products unfit for consumption. Arsenic (As) is a potentially hazardous metalloid that severely impacts plants' survival. Menthol mint (Mentha arvensis L.) bears volatile compounds that are harshly exaggerated by diverse environmental factors like drought, salinity, heavy metal, temperature, photoperiod, and luminosity stresses. In this study, the phytotoxicity of As was examined in M. arvensis L. and its alleviation through the supplementation of oligomers of carrageenan. Noticeably, scanty information is available regarding the effect of irradiated carrageenan (ICA) on As-stressed plants. In order to observe the same in the case of M. arvensis L., the effect of ICA on As-treated plants was explored. The ICA concentration (foliar-applied) selected for the study was 80 mg L-1, 100 mg L-1 and 120 mg L-1, and that of As (soil-applied) was 80 mg kg-1 soil. Excess accumulation of As resulted in reduced growth, enzymatic activities, and yield and quality parameters of M. arvensis L. under As toxicity. However, the foliage application of ICA strengthens the antioxidant machinery and other physiological and oxidative stress biomarkers of the plant by facilitating the activity of superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), and proline, and, therefore aids in alleviating the toxicity generated by As. Nevertheless, ICA supplementation proves beneficial in enhancing the monoterpene synthesis (essential oil production and its active constituents) of M. arvensis L. by maintaining a steady-state equilibrium between reactive oxygen species (ROS) production and its scavenging process.

Slide-tags enables single-nucleus barcoding for multimodal spatial genomics.

Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex tissues are constructed1-6. However, missing from these measurements is the ability to routinely and easily spatially localize these profiled cells. We developed a strategy, Slide-tags, in which single nuclei within an intact tissue section are tagged with spatial barcode oligonucleotides derived from DNA-barcoded beads with known positions. These tagged nuclei can then be used as an input into a wide variety of single-nucleus profiling assays. Application of Slide-tags to the mouse hippocampus positioned nuclei at less than 10 µm spatial resolution and delivered whole-transcriptome data that are indistinguishable in quality from ordinary single-nucleus RNA-sequencing data. To demonstrate that Slide-tags can be applied to a wide variety of human tissues, we performed the assay on brain, tonsil and melanoma. We revealed cell-type-specific spatially varying gene expression across cortical layers and spatially contextualized receptor-ligand interactions driving B cell maturation in lymphoid tissue. A major benefit of Slide-tags is that it is easily adaptable to almost any single-cell measurement technology. As a proof of principle, we performed multiomic measurements of open chromatin, RNA and T cell receptor (TCR) sequences in the same cells from metastatic melanoma, identifying transcription factor motifs driving cancer cell state transitions in spatially distinct microenvironments. Slide-tags offers a universal platform for importing the compendium of established single-cell measurements into the spatial genomics repertoire.

E-beam irradiation-induced synthesis of hydroxyethyl cellulose/(Cu2O-rGO)/BiVO4-based nanocomposite for photocatalytic remediation of wastewater under visible light.

Using E-beam irradiation as an eco-friendly technique for initiation and crosslinking, a series of Hydroxyethyl Cellulose-poly vinyl alcohol copolymer hydrogels were synthesized as templates for cuprous oxide (Cu2O), reduced graphene oxide (rGO) and bismuth vanadate (BiVO4) nanoparticles to be used as nanocomposites photocatalysts for methylene blue (MB) dye decolorization using visible light. Preparation conditions were optimized to ensure the construction of a good network architecture and therefore the highest gelation degree. For the preparation of (Cu2O@rGO)/BiVO4 nanocomposites, a series of rGO was decorated by Cu2O using the precipitation method, followed by mixing with BiVO4 which was synthesized hydrothermally. (EDX), (XRD), (TEM), and (SEM) were used for nanoparticle characterization. The thermal characteristics of the fabricated nanocomposites were evaluated using thermal gravimetric analysis. The presence of rGO enhanced the decolorization efficiency of MB about 20 % higher than that of (HEC-PVA)/Cu2O which achieves only (59 %) decolorization efficiency. After the addition of BiVO4 NPs, the decolorization efficiency increased to reach 90 % after 150 min at pH 11 using a 10 ppm MB solution. The developed (HEC-PVA)/(Cu2O@rGO)/BiVO4 photocatalyst exhibits efficient reusability for 5 cycles. Treated dyed water shows a germination index (GI) of 82 % suggesting its suitability for irrigation of playgrounds and gardens.

Use of wheat dilution to improve digestive function in broilers: application in low protein diets.

1. This study evaluated the effect of wheat dilution increasing in particle size in low crude protein diets on growth performance, digestive tract, nitrogen efficiency and litter quality in broiler chickens.2. Ross 308 male broiler chicks (n = 336) were allocated to one of four dietary treatments (each with 7 pens, 12 chicks per pen); Control (CON; commercial pellet diet with standard crude protein, CP: 22.50%), W578 (CON +20% wheat of geometric mean diameter (GMD) of 578 µm; CP: 20.25%), W1326 (CON +20% wheat of GMD 1326 µm; CP: 20.25%) and WW (CON +20% whole wheat, CP: 20.25%), from d 0 to 21 of age.3. Body weight gain was increased (P < 0.05) for birds fed CON compared to the low crude protein diets. However, WW increased (P < 0.05) body weight gain compared to W578 and W1326, while feed intake and feed conversion ratio on CON and WW were similar (P > 0.05). Birds fed W1326 showed the poorest (P < 0.05) FCR compared to CON, W578 and WW.4. Gizzard relative weight (g/kg body weight) was increased (P < 0.05) on WW compared to CON on d 14 and 21, whereas gastric isthmus diameter was significantly reduced on W1326 and WW compared with CON and W578.5. There were no differences (P > 0.05) in the depth of gizzard mucosa of lamina propria between CON and WW at d 14 and 21. Birds fed WW increased (P < 0.05) gizzard tensile strength compared to W578 and W1326, whereas no difference was observed between WW and CON on d 14.6. No significant differences were seen for ileum villus height and mucosal layer between CON and WW on d 21, however, feeding CON increased the extent of the mucosal layer compared to W578 and W1326.7. Nitrogen excretion (g/kg BWG) was significantly lower (P > 0.05) on W1326 and WW compared with CON and W578. Litter nitrogen, moisture, and footpad scores significantly decreased (P < 0.05) for birds fed WW compared with CON.8. Diluting dietary protein content from 22.50 to 20.25% resulted in lower body weight gain in broilers. However, dilution with whole wheat resulted in comparable FCR, reduced nitrogen excretion, litter moisture and footpad dermatitis compared with a standard protein diet.

Preparation, Optimization and In vitro Evaluation of Doxorubicin-loaded into Hyaluronic Acid Coated Niosomes Against Breast Cancer.

Doxorubicin (DOX) is widely used against solid tumors. Niosomes are self-assembled nanocarriers of non-ionic surfactants. DOX loaded into cationic niosomes (DOX-Nio) was prepared via thin film hydration method. DOX-Nio was then decorated with a hyaluronic acid (DOX-HA-Nio) via electrostatic interaction. DOX-Nio and DOX-HA-Nio displayed a particle size of 120.0±1.02 and 182.9±2.3 nm, and charge of + 35.5±0.15 and -15.6±0.25 mV, respectively, with PDI < 0.3. DOX-HA-Nio showed a good stability regarding size and charge over 4 weeks at 4 °C and maintain their integrity after lyophilization. HPLC results showed a 94.1±4.2 % encapsulation efficiency of DOX with good entrapment and slow, prolonged DOX release even after 48 hrs. Cell viability assay showed an IC50 of 14.26 nM for the DOX-HA-Nio against MCF-7 cell line with micromolar IC50 results against CD-44 negative cell lines (NIH/3T3). DOX-HA-Nio was proven to be an effective, targeted nanocarrier for DOX against MCF-7 cell line.

The molecular cytoarchitecture of the adult mouse brain.

The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within individual anatomical structures remain incompletely known. To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq1,2-a recently developed spatial transcriptomics method with near-cellular resolution-across the entire mouse brain. Integration of these datasets revealed the cell type composition of each neuroanatomical structure. Cell type diversity was found to be remarkably high in the midbrain, hindbrain and hypothalamus, with most clusters requiring a combination of at least three discrete gene expression markers to uniquely define them. Using these data, we developed a framework for genetically accessing each cell type, comprehensively characterized neuropeptide and neurotransmitter signalling, elucidated region-specific specializations in activity-regulated gene expression and ascertained the heritability enrichment of neurological and psychiatric phenotypes. These data, available as an online resource ( www.BrainCellData.org ), should find diverse applications across neuroscience, including the construction of new genetic tools and the prioritization of specific cell types and circuits in the study of brain diseases.

Real-World Evidence to Evaluate the Efficacy and Safety of Vonoprazan in Gastrointestinal Disorders in the Pakistani Population.

BACKGROUND AND AIM: While proton pump inhibitor (PPI) therapy has proven to be effective in managing gastroesophageal reflux disease (GERD), a notable portion of patients who experience GERD symptoms may not respond to this treatment. Research suggests that roughly 30% of individuals with a presumed GERD diagnosis may continue to experience symptoms, whether partially or completely, even when receiving PPI therapy. The aim of this study was to assess the treatment of gastrointestinal diseases with a novel potassium-competitive acid blocker (P-CAB), vonoprazan, in terms of its effectiveness and safety in the Pakistani population. METHODS: This prospective, multicenter, observational study was conducted in Pakistan. This study included 1,642 patients from January 2023 to August 2023, aged 18 years, with gastrointestinal disorders. All demographic data, medical history, GERD severity assessment questionnaire (GerdQ), and laboratory parameters, including stool assessment for Helicobacter pylori (H. pylori), were observed. Patients were orally treated with vonoprazan at doses of 10 mg or 20 mg, once or twice daily. Statistical analysis was done by one-way ANOVA. RESULTS: Out of 1,642 patients, 840 (51.2%) were males and 802 (48.8%) were females, with a mean age of 39.81±14.61 years. The mean GerdQ score at baseline was 20.37±15.87, 7.24±8.15 at the second week of treatment, and 3.70±6.31 at the fourth week of treatment (p<0.001). 90.74% of patients achieved H. pylori eradication. Most patients were acid regurgitation and heartburn-free for >70% of days. Most of the patients, 1,283 (78.13%), exhibited good treatment compliance. Mild adverse events were reported in 37 (2.3%) patients. CONCLUSIONS: The use of vonoprazan significantly reduced the likelihood of GERD by improving symptoms and was also highly effective in the elimination of H. pylori infections. Vonoprazan was generally well tolerated.

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.

In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. We show that PCs directly inhibit parabrachial nuclei (PBN) neurons that project to numerous forebrain regions. Suppressing the PC-PBN pathway influences many regions in the forebrain and is aversive. Molecular profiling shows that PCs directly inhibit numerous types of PBN neurons that control diverse behaviors that are not involved in motor control. Therefore, the PC-PBN pathway allows the cerebellum to directly regulate activity in the forebrain, and may be an important substrate for cerebellar disorders arising from damage to the posterior vermis.

Xylo-oligosaccharide-based prebiotics upregulate the proteins of the Sus-like system in caecal Bacteroidetes of the chicken: evidence of stimbiotic mechanism.

The present study was conducted to investigate the stimbiotic mechanism of xylo-oligosaccharide (XOS) in degrading the complex polysaccharides by the caecal bacteria of the chicken, by applying a proteomic approach. A total of 800 as-hatched Ross 308 broiler chicks were equally divided into 4 experimental pens (200 chicks per pen) at a commercial poultry barn, allocating 2 pens per treatment. Birds were fed ad libitum with 2 dietary treatments; CON (without XOS) and XOS (with 0.1g XOS/kg diet) from d 0 to 35. From each pen, 60 Individual birds were weighed weekly whereas caecal content was obtained from 5 birds cervically dislocated on d 35. The caecal bacteria were lysed and their proteins were quantified using label-free quantitative proteomic mass spectrometry. The results showed that XOS significantly increased (P < 0.05) bird weight on d 7, 14, 21, and 28, and body weight gain on d 7, 14, 21, and 35 compared to CON. However, no difference (P > 0.05) in body weight gain was observed from d 0 to 35 between CON and XOS. The proteomic analysis of caecal bacteria revealed that 29 proteins were expressed differently between the CON and the XOS group. Out of 29, 20 proteins were significantly increased in the XOS group compared to CON and 9 of those proteins belonged to the starch-utilizing system (Sus)-like system of the gram-negative Bacteroidetes. Bacteroides thetaiotaomicron (Bt) is a significant constituent of the human gut microbiota, known for its remarkable ability to hydrolyze most glycosidic bonds of polysaccharides. This microorganism possesses a 5-protein complex in its outer membrane, named the starch utilization system (Sus), responsible for adhering to, breaking down, and transporting starch into the cell. Sus serves as an exemplar system for numerous polysaccharide utilization loci that target glycans found in Bt and other members of the Bacteroidetes phylum. The proteins of the Sus-like system are involved in the degradation of complex polysaccharides and transportation of the oligosaccharides into the periplasm of the caecal bacteria where they are further broken down into smaller units. These smaller units are then transported into the cytoplasm of the cell where they are utilized in metabolic pathways leading to potential generation of short-chain fatty acids, thus improving the nutritive value of residual feed. In conclusion, XOS supplementation upregulates the expression of the proteins of the Sus-like system indicating its role as a stimbiotic.

Early Alzheimer's disease pathology in human cortex involves transient cell states.

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with varying degrees of AD pathology. We next performed a systematic cross-disease and cross-species integrative analysis to identify a set of cell states that are specific to early AD pathology. These changes-which we refer to as the early cortical amyloid response-were prominent in neurons, wherein we identified a transitional hyperactive state preceding the loss of excitatory neurons, which we confirmed by acute slice physiology on independent biopsy specimens. Microglia overexpressing neuroinflammatory-related processes also expanded as AD pathology increased. Finally, both oligodendrocytes and pyramidal neurons upregulated genes associated with ß-amyloid production and processing during this early hyperactive phase. Our integrative analysis provides an organizing framework for targeting circuit dysfunction, neuroinflammation, and amyloid production early in AD pathogenesis.

Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive.

Animals adapt to varying environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here we find that thyroid hormone- a prominent regulator of metabolism in many peripheral organs- activates cell-type specific transcriptional programs in anterior regions of cortex of adult mice via direct activation of thyroid hormone receptors. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulators across both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread remodeling of cortical circuits. Indeed, whole-cell electrophysiology recordings revealed that thyroid hormone induces local transcriptional programs that rewire cortical neural circuits via pre-synaptic mechanisms, resulting in increased excitatory drive with a concomitant sensitization of recruited inhibition. We find that thyroid hormone bidirectionally regulates innate exploratory behaviors and that the transcriptionally mediated circuit changes in anterior cortex causally promote exploratory decision-making. Thus, thyroid hormone acts directly on adult cerebral cortex to coordinate exploratory behaviors with whole-body metabolic state.

Efficacy of oat hulls varying in particle size in mitigating performance deterioration in broilers fed low-density crude protein diets.

Dietary fibres with increased particle size may develop foregut more efficiently in meat poultry fed diets moderately low in crude protein. The study investigated the performance of broilers fed low-density crude protein diets with the inclusion of oat hulls increasing in particle size. Ross 308 male broiler chicks (n = 336) were divided into 48 pens, 12 pens per treatment (7 chicks per pen). Pens were allocated to 4 dietary treatments in mash form; positive control (PC), a standard crude protein diet, negative control (NC), around 5% lower in protein with 5% celite as an inert material, OH400: 5% lower protein diet with 5% oat hulls of geometric mean diameter (GMD) 400 µm, OH850: 5% lower protein diet with 5% oat hulls of GMD 850µm. Birds were fed ad libitum from d 1 to 35 in 3 phases; starter: d 0 to 10, grower: d 10 to 24 and finisher: d 24 to 35. Growth performance was calculated at the end of the trial. Two birds per pen were sampled on d 24 and 35 to collect data on proventriculus and gizzard weights and pooled ileal digesta. Apparent ileal digestibility of amino acids on d 24, and metabolizable energy on d 24 and 35 were recorded for each pen. Litter was sampled from each pen on d 34 to analyze litter N and moisture content. Footpad dermatitis scores of all birds per pen were recorded on d 35. Overall, no difference (P > 0.05) in body weight gain and feed intake was found between the treatments. However, NC and OH400 showed poorer FCR than PC, whereas FCR on PC and OH850 was similar (P > 0.05). Gizzard absolute weight and relative to body weight, and gizzard to proventriculus ratio were higher (P < 0.05) on OH850 compared to PC and NC on d 24 and 35. Gizzard digesta particle size was reduced (P < 0.05) on OH850 compared to all other diets on d 24 and 35. Amino acids digestibility coefficients for aspartic acid and valine increased (P < 0.05) in birds fed OH850 compared to PC, whereas coefficients for several other amino acids were improved compared to NC and OH400. The apparent ileal digestibility of metabolizable energy was similar (P > 0.05) between PC and OH850. Litter moisture and nitrogen, and footpad dermatitis scores were reduced (P < 0.05) on OH850 compared to PC. In conclusion, the inclusion of coarse oat hulls of GMD 850 µm in low-density crude protein diets can be beneficial for the broilers in developing the foregut, utilizing the nutrients efficiently and reducing litter nitrogen and moisture, and footpad scores.