RESUMO
A 78-year-old woman underwent gastrectomy for type 3 gastric cancer with pyloric stenosis, which was detected in November 1997. Thoracic and abdominal CT and other diagnostic procedures were conducted regularly for 5 years after surgery. The patient was recurrence-free and her clinical course was satisfactory. Starting in early May 2005, however, she began to experience respiratory difficulty at exertion, which exacerbated rapidly thereafter. Examination at a department of respiratory physiology led to a diagnosis of a recurrence of stomach cancer and carcinomatous lymphangiosis+lymphatic metastasis to the peritoneal cavity. She was referred to us for palliative care. The accentuated respiratory difficulty was eased with oxygen inhalation and opioid administration. With improvement in her respiratory condition, a combination of S-1 80 mg/day, CDDP 10 mg x once/week and Lentinan 1 mg x twice/week, was initiated. Within about 2 weeks, her respiratory difficulty was eliminated and after 4 weeks x 2 courses, the tumor images were no longer recognized in the thoracic and abdominal CTs. The combination therapy of S-1/low-dose CDDP/Lentinan is free of evident adverse effects and may be a potent therapeutic alternative as a palliative therapy for malignant stomach cancers in elderly patients or those in a poor systemic condition.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Cisplatino/uso terapêutico , Lentinano/uso terapêutico , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/secundário , Ácido Oxônico/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Tegafur/uso terapêutico , Idoso , Combinação de Medicamentos , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Metástase Linfática/diagnóstico por imagem , Metástase Linfática/patologia , Recidiva , Neoplasias Gástricas/patologia , Neoplasias Gástricas/cirurgia , Fatores de Tempo , Tomografia Computadorizada por Raios XRESUMO
A 79-year-old female who was surgically treated and received adjuvant chemotherapy for primary non-Hodgkin's lymphoma of the descending colon with massive extension into the pancreatic tail, spleen, and left kidney is herein reported. The patient had acute colonic obstruction and an urgent laparotomy was performed because endoscopic decompression using a transnasal ileus tube could not be done. We performed a left colectomy with an en bloc resection of the neighboring organs, followed by the creation of an end colostomy. The patient had no major postoperative complications and is well without any recurrence of lymphomas 6 months after surgery.
Assuntos
Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Linfoma não Hodgkin/patologia , Linfoma não Hodgkin/cirurgia , Idoso , Quimioterapia Adjuvante , Doenças do Colo/etiologia , Neoplasias do Colo/complicações , Colonoscopia , Feminino , Humanos , Imuno-Histoquímica , Obstrução Intestinal/etiologia , Linfócitos/patologia , Linfoma não Hodgkin/complicações , Invasividade NeoplásicaRESUMO
We treated a 77-year-old Japanese man with cutaneous metastases from pancreatic adenocarcinoma. Physical examinations revealed reddish, non-tender and firm nodules in left axilla. Laboratory examination showed a remarkable elevation in the tumor markers of CA 19-9, DUPAN-2 and SPAN-1. Abdominal computed tomography showed a low-density mass in the tail of the pancreas, and histological examination of nodule in the axilla revealed a metastatic adenocarcinoma. The immunohistochemistry of CA 19-9 in the excised nodule was positive. Cutaneous metastasis from pancreatic adenocarcinoma is usually rare, and the prognosis is poor, as the disease is usually advanced.
Assuntos
Adenocarcinoma/diagnóstico , Adenocarcinoma/secundário , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/secundário , Adenocarcinoma/terapia , Idoso , Humanos , Masculino , Neoplasias Pancreáticas/terapia , Neoplasias Cutâneas/terapiaRESUMO
Arteriovenous malformation of the pancreas is a rare condition that may cause upper gastrointestinal bleeding. A 58-year-old man with an arteriovenous malformation of the pancreas is described. The patient had recurrent episodes of melena. The diagnosis was confirmed by angiographic study and color Doppler ultrasonography. Therapeutic embolization of the arteriovenous malformation was successfully carried out. In conclusion, transcatheter arterial embolization should be chosen for the patient with the pancreatic arteriovenous malformation.