Association between high-sensitivity C-reactive protein with arterial stiffness in healthy Korean adults.

BACKGROUND: The detection of preclinical arterial dysfunction may improve the ability to predict the subsequent risk of its outcomes and lead to optimal strategies to prevent overt vascular damage. The aim of this study was to investigate whether high high-sensitivity C-reactive protein (hsCRP) is associated with increased arterial stiffness in Korean adults. METHODS: The association between the hsCRP and cardiac-ankle vascular index (CAVI) was evaluated in 1347 healthy adults. Multivariate logistic analyses were done to identify the association of the hsCRP levels and high CAVI (≥ 8.0). RESULTS: The age and gender adjusted mean values of the CAVI were significantly higher in the intermediate and high hsCRP groups than in the low hsCRP group. For all the study subjects, an intermediate and high hsCRP was associated with a high CAVI after adjusting for covariates. However, this association was observed only in female subjects in gender-specific analyses and did not change after further adjustment for other variables. CONCLUSIONS: Even within the normal range, a high hsCRP level was a predictor of high CAVI in healthy adult females. This finding suggests that the risk of arteriosclerosis may be high in females whose hsCRP level is > 0.1mg/dl even in low-risk females.

Epidermal growth factor receptor as a predictor of tumor downstaging in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy.

PURPOSE: To examine retrospectively whether levels of epidermal growth factor receptor (EGFR) expression can predict tumor downstaging after preoperative chemoradiotherapy in patients with locally advanced rectal cancer. METHODS AND MATERIALS: A total of 183 patients with rectal cancer (cT3-T4 or N+) were enrolled in this study. Preoperative chemoradiotherapy consisted of 50.4 Gy of pelvic radiation with concurrent 5-fluorouracil and leucovorin bolus intravenous chemotherapy in 94 patients or oral capecitabine and leucovorin in 89 patients. EGFR expression in pretreatment paraffin-embedded tumor biopsy specimens was assessed by immunohistochemistry. EGFR expression was determined from the intensity and extent of staining. Tumor downstaging was defined as a reduction of at least one T-stage level. RESULTS: Tumor downstaging occurred in 97 patients (53%), and the tumors showed a pathologic complete response in 27 patients (15%). Positive EGFR expression was observed in 140 (76%) of 183 patients. EGFR expression levels were low in 113 patients (62%) and high in 70 patients (38%). On logistic regression analysis, the significant predictive factor for increased tumor downstaging was a low level of EGFR expression and preoperative chemotherapy using oral capecitabine (odds ratio, 0.437; p = 0.012 vs. odds ratio, 3.235; p < 0.001, respectively). CONCLUSION: A high level of EGFR expression may be a significant predictive molecular marker for decreased tumor downstaging after preoperative chemoradiotherapy in locally advanced rectal cancer.