[Fluoroquinolones in the therapy of gonorrheal-chlamydial infection (a clinical and electron microscopic study)]. / Ftorkhinolony v terapii gonoreino-khlamidiinoi infektsii (kliniko-élektronnomikroskopicheskoe issledovanie).

Highly efficient methods for the treatment of gonorrheal and gonorrheal-chlamydial infections with fluorquinolones were developed and introduced into medical practice. The methods are pathogenetically substantiated. The etiological recovery in the patients treated with tarivid, quintorom and abaktal amounted to 97.8, 96 and 95.6 per cent respectively. The subcellular examinations of ultrathin sections of the pathological material from the patients with gonorrheal-chlamydial infection showed that the association of gonococcus and Chlamydia resulted in hyperproduction of drop-like formations that had a toxic action on leukocytes in the infection foci.

[Protegentin--a combined preparation for the local treatment of suppurative infection]. / "Protégentin"--kombinirovannyi preparat dlia mestnogo lecheniia gnoinoi infektsii.

Protegentin is a formulation in the form of an ointment for local application. Its high efficacy was demonstrated in the treatment of wounds in the 1st phase of the process, extended decubitus, trophic ulcers, wounds of various genesis not healing for prolonged periods, urogenital infections, abscesses, maxillofacial phlegmon and abscessing parodontosis. The ointment showed good draining, proteolytic and bactericidal effects. The tolerance was good. The positive results were observed in 97 per cent of the cases.

[Ofloxacin and ciprofloxacin in the treatment of sexually-transmitted diseases]. / Ofloksatsin i tsiprofloksatsin v terapii infektsii, peredavaemykh polovym putem.

A complex clinico-laboratory++ examination and treatment were made of 76 women with inflammatory processes in the urogenital tract. Gonorrhea, trichomoniasis, chlamydiosis and Ureaplasma infection were detected in 60, 31.4, 41 and 14 per cent of the cases, respectively. There were affections of the rectum by gonococci, chlamydia, ureaplasmas and Trichomonas in 55, 32, 10.6 and 6.6 per cent of the cases, respectively. The frequency of chlamydia in the oropharynx amounted to 30 per cent whereas gonococci and ureaplasma were less frequent i.e. 9 and 1.2 per cent, respectively. The combination of the above pathogens in the rectum were the following: gonococci and chlamydia (15 per cent of the cases), gonococci, chlamydia and Trichomonas (7.3 per cent), gonococci and ureaplasma (7.3 per cent), ureaplasma and chlamydia (7.8 per cent). In the throat the association of gonococci and chlamydia was detected in 3.7 per cent of the cases. It should be indicated that the signs of sex-transmitted diseases were few, which required careful clinico-laboratory examination of the extragenital foci in the patients with inflammatory urogenital diseases. Ofloxacin showed a high efficacy in the treatment of patients with gonorrhea and ureaplasmosis. Its use in treatment of chlamydiosis proved inexpedient while ciprofloxacin was effective in the treatment of the infection.

[The level of penicillin in the blood serum during treatment of gonococcal infection with various doses of bicillin-3 and its combination with etamid]. / Soderzhanie penitsillina v syvorotke krovi pri lechenii gonokokkovoi infektsii razlichnymi dozami bitsillina-3 i kombinatsiei ego s étamidom.

Bicillin-3 has been administered to patients with new gonorrheal urethritis in doses of 3,000,000 U, 2,400,000 U, and 2,400,000 U + ethamide. The latter combination has proved to be the most effective.

[The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits]. / Vliianie nikotinamida, nikotinovoi i askorbinovoi kislot na kontsentratsiiu penitsillina v syvorotke krovi i tkaniakh krolikov.

Measurements of penicillin concentrations in the blood sera and tissues of rabbits have revealed a reduction of this antibiotic levels as the doses of injected ascorbic acid grew. A combination of benzylpenicillin with ascorbic and nicotinic acids improved penicillin penetration into experimental animals' tissues.

[Microbial flora sensitivity to antibacterial agents in chronic pyelonephritis patients who have had acute kidney failure]. / Chuvstvitel'nost' mikrobnoi flory k antibakterial'nym sredstvam u bol'nyklh s khronicheskim pielonefritom, perenesshikh ostruiu pochechnuiu nedostatochnost'.

The analysis of antibioticograms of patients with a history of chronic pyelonephritis and acute renal insufficiency is presented. It was found that the synergistic effect observed with the use of gentamicin in combination with carbenicillin or ampicillin with cephaloridin provides a decrease in the therapeutic doses of the drugs with a purpose of elimination of their side action.

[Methods of determining admixtures in commercial preparations of tetracycline]. / Metody opredeleniia primesei v tovarnykh preparatakh tetratsiklina

The results and conditions of separation and quantitative determination of the admixtures of epi- and anhydro-derivatives of tetracycline in its market products were compared and analyzed using the following chromatographic methods: chromatography in a thin layer of a sorbent in 2 modifications, circular paper chromatography, chromatography on a column of gel Sephadex G-25. The comparison of the results of the study provided recommendation of the column chromatography with gel Sephadex G-25 for separate or summation quantitative determination of 4-epitetracycline. The method of chromatography in a thin layer of a sorbent may be successfully used for semiquantitative determination of the admixture levels in tetracycline market drugs.