RESUMO
Tissue reactions to the grafting of samples of composite hydrogel based on polyacrylamide and cellulose of different origin (plant and bacterial) were studied in 48 laboratory outbred rats and 24 rabbits of chinchilla breed. The observations were carried out on Days 5, 14, 45 and 90 after placement of implants in the muscle, joint cavity, deep defects of the articular cartilage and subchondral bone. The study has revealed no migration and degradation of the samples. On Day 90, the signs of their biointegration (regardless of their nature) were detected in the muscles and in one case (the sample containing bacterial cellulose) in the cavity of the knee joint of the rat. The materials had good biocompatibility with muscle, cartilage and bone tissues, did not cause perifocal inflammation and effectively functioned as a prosthetic articular cartilage until the end of the study period.
Assuntos
Resinas Acrílicas , Celulose , Reação a Corpo Estranho , Hidrogéis , Teste de Materiais , Resinas Acrílicas/química , Resinas Acrílicas/farmacologia , Animais , Celulose/química , Celulose/farmacologia , Feminino , Reação a Corpo Estranho/metabolismo , Reação a Corpo Estranho/patologia , Hidrogéis/química , Hidrogéis/farmacologia , Coelhos , RatosRESUMO
The siloxan film with programmed physiochemical characteristics possessing antimicrobial properties is proposed for the prevention of cicatrization in the knee joint area. Using this film as a pad after mobilizing operations on the knee joint has shown its high efficiency and considerably improved results of treatment.
Assuntos
Cicatriz/prevenção & controle , Contratura/cirurgia , Articulação do Joelho/cirurgia , Próteses e Implantes , Silicones , Siloxanas , Humanos , Técnicas de SuturaRESUMO
214 patients with posttraumatic contractures of the knee joint were treated at the Leningrad Research Institute of Orthopaedics and Traumatology in 1970-1985. In 67 patients the Thompson-Kaplan operation was performed. Since 1980 an operation worked out at the Institute has been made in 194 patients. Their treatment results were much better, especially in the patients with the most severe contractures of the knee joint which developed after diaphyseal and intraarticular fractures of the femur as well as after preceding osteomyelitis or purulent gonitis.