[DR. ARIEH LEIB SHIMONI-MEKLER - EYE, EAR, NOSE AND THROAT SPECIALIST].

Although the inauguration of the new hospital in Zefat built by Baron Rothschild took place in 1910, the building was not used as a hospital until World War I when it was confiscated by the Turks for patients affected with typhus, and later it was converted into a military hospital. The second inauguration of the renewed hospital was in June 1919, and the medical activity was assigned to the American Zionist Medical Unit for Palestine' (AZMU), later - 'Hadassah Medical Organization'. Among the first doctors that were sent to Zefat by AZMU was Dr. Arieh Leib Shimoni-Mekler - Eye, Ear, Nose and Throat specialist. Dr. Shimoni-Mekler worked in the hospital during the years 1921-2.

[Dr. Moshe Sherman--the first otolaryngologist in Eretz-Israel: 100 years since his arrival].

On 4.8.1911 Dr. Moshe Sherman landed at the port of Jaffa. He was the first otolaryngologist in Eretz-Israel and for one year he was the only specialist in the country. Dr. Sherman was born in Nikolayev (Russia) in 1881. He started his medical education in Odessa, continued in Berlin, graduated in 1907 at the University of Dorpat (Estonia) and pursued postgraduate studies in otolaryngology at Moscow University. He settled in Jaffa, started a private practice and soon became a famous specialist. He volunteered at the Jewish hospital in Jaffa--"Shaar Zion", and twice a year spent several weeks in Jerusalem seeing patients and performing small operations. On January 1912 Dr. Sherman, together with another 5 physicians, laid the foundations for the first doctors' organization in Israel: "The Medical Society of Jaffa and Jaffa district". In 1918 Dr. Sherman was elected consultant at the Hadassah Hospital in Tel Aviv, and in 1932 a department for ear, nose and throat diseases was established there under his management. He was the founder and first chairman of the Ototaryngology Society in Eretz-Israel, and in 1935 was elected the chairman of the Jewish Medical Association in Eretz-Israel (later--its honorary president). He was the initiator and founder of the "World Fellowship", and the Editor in Chief of 'Harefuah' and "Michtav Lachaver". Dr. Sherman was the author of numerous papers related to his specialty and to the history of Jewish organizations in Eretz-Israel and, later, in the State of Israel. Dr. Sherman died in Tel Aviv on July 17th 1969.

Implanted upper airway stimulation device for obstructive sleep apnea.

OBJECTIVES/HYPOTHESIS: Previous feasibility studies have shown that electrical stimulation of the hypoglossal nerve can improve obstructive sleep apnea (OSA). The current study examined the safety and preliminary effectiveness of a second generation device, the Upper Airway Stimulation (UAS) system, and identified baseline predictors for therapy success. STUDY DESIGN: Two consecutive open prospective studies. METHODS: UAS systems were implanted in patients with moderate to severe OSA who failed or were intolerant of continuous positive airway pressure (CPAP). The study was conducted in 2 parts. In part 1, patients were enrolled with broad selection criteria. Apnea hypopnea index (AHI) was collected using laboratory-based polysomnography at preimplant and postimplant visits. Epworth Sleepiness Scale (ESS) and Functional Outcomes of Sleep Questionnaire (FOSQ) were also collected. In part 2, patients were enrolled using selection criteria derived from the experience in part 1. RESULTS: In part 1, 20 of 22 enrolled patients (two exited the study) were examined for factors predictive of therapy response. Responders had both a body mass index ≤32 and AHI ≤50 (P < .05) and did not have complete concentric palatal collapse. Part 2 patients (n = 8) were selected using responder criteria and showed an improvement on AHI from baseline, from 38.9 ± 9.8 to 10.0 ± 11.0 (P < .01) at 6 months postimplant. Both ESS and FOSQ improved significantly in part 1 and 2 subjects. CONCLUSIONS: The current study has demonstrated that therapy with upper airway stimulation is safe and efficacious in a select group of patients with moderate to severe OSA who cannot or will not use CPAP as primary treatment.

[A prophet without honor in his own country: Dr. Ernst Wodak (1891-1962)].

Among all otolaryngologists who lived in Israel during the first half of the 20th century, one was most prominent - Dr. Ernst Wodak. Ernst Wodak was born in Czechoslovakia in 1891 and he graduated from the German University of Prague in 1915. Dr. Wodak was a knowledgeable clinician and an outstanding researcher. He was mainly interested in the vestibular system, and already started to publish the results of his observations in 1914. In a short time Dr. Wodak became famous all over Europe. He was on the Editorial Boards of the Acta Oto-Laryngologica, and of the Excerpta Medica, and a member of the International Collegium Otolaryngologicum. In 1939, following the invasion of Czechoslovakia by the Germans, Dr. Wodak had to leave his work, and soon after he immigrated to Israel and settled in Tel-Aviv. For 5 years he volunteered in the ENT department in 'Hadassah' Hospital. Even though he was already famous worldwide, Dr Wodak was not appreciated by most of his colleagues nor by the academic authorities. He could not continue his research and was forced to work only in his private clinic and mainly performed plastic and cosmetic operations. In spite of his frustration, Dr. Wodak did not lose the drive to publish and continued to contribute important papers to medical journals both in Israel and abroad. He published more than 200 papers and also wrote a few books. Dr Wodak died on 27.4.1962 following a prolonged period of pain and suffering, away from his wife and daughter and abandoned by most of his friends.

Abrupt tonsillar hemorrhage from a metastatic hemangiosarcoma of the breast: case report and literature review.

We describe a case of primary breast hemangiosarcoma with tonsillar metastasis that manifested as a profuse oropharyngeal hemorrhage. The patient was a 54-year-old woman who presented to the emergency department with oral bleeding. A thorough examination revealed a distorted morphology of the left tonsil and a hemorrhage originating from it. Conservative methods to control the hemorrhage failed, and tonsillectomy was carried out. Histopathologic analysis revealed that the left tonsil contained hemangiosarcoma cells of the same kind that had been removed from the breast. Primary hemangiosarcomas of the breast are rare; when they do occur, they usually recur locally and spread hematogenously. To the best of our knowledge, this is the first case of a primary breast hemangiosarcoma with tonsillar metastasis to be reported in the literature. We present a detailed analysis of this case, and we review the relevant literature on metastatic tonsillar tumors, with attention to the role of therapeutic embolization.

[Frontal sinus fractures: five years of treatment experience].

BACKGROUND: Frontal sinus fractures are commonly encountered in major trauma centers. They are almost exclusively seen in young adults and are usually caused by high velocity impacts. The intimate association of the frontal sinuses with structures such as frontal lobes and the eyes makes the appropriate management of this injury essential. PURPOSE: To review patients that suffered from frontal sinus fractures and underwent surgery, and to evaluate the efficacy and complications of this treatment. METHODS: This is a retrospective study. The study population included all the patients that suffered from frontal sinus fracture and underwent a surgical intervention between the years 1998-2002. The data that was collected included demographic parameters, cause of injury, timing and kind of surgery, postoperative complications and patient satisfaction. RESULTS: A total of 47 patients were operated on due to frontal sinus fractures during the years 1998-2002. Only 38 had adequate follow-up. Seventy percent of the patients suffered from bitable fractures. The other 30% had only anterior wall fractures. A total of 47% of the patients had additional facial fractures and 39% had intracranial injuries. Most of the patients were operated on during the first 24 hours (50%). The incidence of major postoperative complications was 2.5% (1 patient had meningitis). Minor complications occurred in 15% of the patients (mainly decreased forehead sensation). CONCLUSIONS: Frontal sinus fractures are commonly seen in major trauma centers. High index of suspicion, careful physical examination and imaging assistance are essential for accurate diagnosis. Lack of appropriate treatment can lead to serious intracranial complications. The surgical intervention achieves good cosmetic and functional outcomes in a majority of the patients.

Safe extraction of an impacted open safety pin from the esophagus: report of 9 cases.

PURPOSE: Foreign body ingestion is a common problem in children. An infrequent ingested item is an open safety pin (SP), which may become lodged in the esophagus and presents the endoscopist a challenge to his surgical judgment and technical skills. MATERIALS AND METHODS: We present 9 cases of infants with open SPs impacted in the esophagus and discuss the different options to treat these cases. RESULTS AND CONCLUSIONS: The management of open SP ingestion is discussed, along with a review of the literature regarding this rare condition.

[Safe extraction of an impacted open safety pin from the esophagus: a new technique and five case studies].

Esophageal foreign bodies are common, especially in children less than 5 years old. However, the presence of an open safety pin in the esophagus is quite rare. When this occurs, immediate removal of the safety pin is recommended due to its propensity to pierce the esophagus and surrounding structures causing severe and sometimes even lethal complications. Between the years 1990 and 2003, fifteen infants were referred to the Department of Otolaryngology-Head and Neck Surgery at the Rambam Health Care Campus with a history of safety pin ingestion. Plain neck, chest and abdomen radiographs showed the presence of an open safety pin impacted in the esophagus and pointing upwards in nine of the cases, and in the remainder (six infants) a closed pin was demonstrated in the stomach or in the duodenum. This report focuses on five cases in which during esophagoscopy only the clasp of the safety pin was visible, whereas the sharp point was impossible to be grasped, as it seemed to be stuck in the mucosa of the esophagus. In these cases the pin was pushed into the stomach, where it was closed, and then it was pulled outside without any harm to the mucosa or the gastric and esophageal walls. We present a new technique on how to safely close an open safety pin in the stomach and remove it, without any complications, using a flexible endoscope.

Does otitis media in early childhood affect reading performance in later school years?

OBJECTIVE: To evaluate reading performance in children with recurrent otitis media during childhood once middle-ear diseases have resolved and the children grew older. STUDY DESIGN AND SETTING: Seventy-five children with middle-ear problems during childhood and poor reading performance in first grades and 60 healthy controls free of middle ear diseases were enrolled in the study. All children underwent an otologic and audiologic evaluation followed by reading tests. RESULTS: Reading performance was not affected once otitis media had been cured and hearing restored; reading scores of the healed children were almost the same as those of the otitis-free children (3.39% and 3.1%, respectively). Children who still suffer from middle-ear problems and hearing loss had an average percentage of reading mistakes of 7.3%. CONCLUSIONS AND SIGNIFICANCE: Once children are cured from their middle-ear diseases and hearing is restored, previously noted reading impairments are no longer evident. Reading is still impaired among children who continue to suffer from middle-ear problems and hearing loss even when they grow older. EBM RATING: B-2b.

Percutaneous tracheotomy in bone marrow transplant patients with severe thrombocytopenia.

OBJECTIVE: Evaluation of percutaneous tracheotomy in bone marrow transplant patients with severe thrombocytopenia. DESIGN: A retrospective outcome study. PATIENTS: A retrospective study of 26 percutaneous tracheotomies was performed at the Bone Marrow Transplant Unit, Rambam Medical Center, Haifa, Israel. Age, sex, underlying disease, reason for intubation, complete blood count, coagulation profile, and the incidence of renal failure were collected. All patients received 6 units of platelets one hour prior to the procedure. RESULTS: The mean platelets count was 14,300 +/- 5500. Twenty-five of the 26 percutaneous tracheotomies were completed successfully, without any intraoperative complications. One patient suffered from moderate bleeding during the procedure, which was immediately stopped and converted to open tracheotomy. In the postoperative period 4 patients suffered from mild bleeding around the stoma, which was managed conservatively. No other late complications were encountered. CONCLUSIONS: Percutaneous tracheotomy can be safely performed in patients with severe thrombocytopenia when the surgeon and anesthesiologist are experienced in the procedure, and platelets are given perioperatively.

Reading performance in children with otitis media.

OBJECTIVE: To examine whether middle ear diseases and the associated hearing loss in early childhood affect reading performance later at school. STUDY DESIGN AND SETTING: One hundred and sixty children, 6.5 to 8 years of age, were enrolled in this study: 80 children with a history of recurrent infections and/or prolonged periods of effusions of the middle ear before the age of 5 years, and 80 healthy children without any history of middle ear disease. Data were collected from the medical records of the children. Every child underwent a complete otological and audiological evaluation, followed by special reading tests. RESULTS: The study group performed more poorly, in all reading tests, as compared to the controls ( P < 0.001). CONCLUSION: Children with recurrent or prolonged middle ear diseases during the first five years of life tend to be at greater risk for delayed reading than aged-matched controls with no previous middle ear diseases.

Delayed diagnosis of tracheoesophageal prosthesis aspiration.

In 1980, Singer and Blom published the results of their study on use of the tracheoesophageal puncture prosthesis for restoration of voice after total laryngectomy. Since then, the placement of tracheoesophageal puncture prostheses has been an integral part of rehabilitation after laryngectomy. Complications of this procedure have been recognized and are usually minimal. Inadvertent aspiration of the prosthesis is rare. Usually, patients seek help immediately after the incident. We report a case of unnoticed aspiration of a Blom-Singer prosthesis in a patient with a laryngectomy.

Extension of nasopharyngeal lymphoma to the middle and external ear.

We describe a patient with nasopharyngeal lymphoma who was admitted for chemotherapy. At admission, otoscopic examination revealed a large polyp occluding the left external ear canal. The polyp was removed, and histopathologic examination showed the same tumor that was found previously in the nasopharynx. Magnetic resonance imaging showed an infiltrative process that involved the left side of the nasopharynx and extended toward the left middle and external ear. To our knowledge, this is the first case report of a direct extension of nasopharyngeal lymphoma into the middle and external ear.

Antioxidants in treatment of idiopathic sudden hearing loss.

OBJECTIVE: Assuming that superoxide anion radicals (O(2)-) may play a role in damage to the inner ear, the authors investigated the possible benefit of vitamin E as an antioxidant in the treatment of idiopathic sudden hearing loss. STUDY DESIGN: Prospective, double-blind study. SETTING: The Department of Otolaryngology of Rambam Medical Center serves as a tertiary referral center for a population of 1.2 million people. PATIENTS: A total of 66 patients, aged 15 to 70 years, with diagnoses of idiopathic sudden hearing loss of less than 7 days' duration during 1998 to 2001, were included in the study. All were treated with bed rest, steroids, magnesium, and carbogen inhalation. The study group received vitamin E in addition. RESULTS: The recovery rate, calculated as hearing gain divided by the difference in hearing level between the affected and unaffected ear, was better than 75% in 41 of 66 (62.12%) patients. This rate was achieved in 26 (78.78%) patients in the study group treated with vitamin E, compared with 15 (45.45%) patients in the control group. CONCLUSIONS: Patients treated with the addition of vitamin E achieved better recovery than did the control patients. Further studies should be directed toward a better understanding of the role of antioxidants in idiopathic sudden hearing loss.

Stapedius muscle myoclonus.

Myoclonus of the middle ear is a very rare condition. We present the case of a 20-year-old soldier who was exposed to intense artillery noise during a fierce battle and immediately afterward complained of an incapacitating tinnitus in both ears. Microscopic examination of the ears demonstrated rapid rhythmic movements of the tympanic membrane coinciding with the tinnitus, which was also easily heard by the examiner. There was no evidence of palatal myoclonus, and thus the diagnosis of middle ear myoclonus was made. Exploratory tympanotomy confirmed the diagnosis of stapedial muscle myoclonus. Bilateral sectioning of the stapedial tendons brought immediate relief of the tinnitus to the patient. We review the literature of middle ear myoclonus and discuss the symptoms, evaluation, and management of this rare condition.

Paper patching for chronic tympanic membrane perforations.

OBJECTIVE: This study was designed to evaluate the results of paper-patch myringoplasty in patients with chronic perforations of the tympanic membrane of different sizes. STUDY DESIGN AND SETTING: A retrospective survey of paper-patch myringoplasties performed in a tertiary referral academic medical center on 77 patients with chronic perforations of the eardrum was carried out. Data consisted of the causes of the perforations, time the perforations had been present, their size, number of patch applications, duration of application, and number of successfully closed perforations. RESULTS: Closure rate was 63.2%, 43.5%, and 12.5% for small, medium, and large perforations, respectively. Small perforations needed the least number of repeated applications and the least time for closure. CONCLUSIONS AND SIGNIFICANCE: Paper patching is technically simple, time saving, safe to perform, cost effective, and suitable as an outpatient procedure and has a good success rate, It should be tried in perforations smaller than 5 mm before a patient is referred for surgery.

Percutaneous dilation tracheotomy versus surgical tracheotomy: our experience.

BACKGROUND: Percutaneous dilation tracheotomy (PDT) is becoming a popular alternative to surgical tracheotomy. In our department, we recently adopted the use of the PDT in intensive care unit patients. Here, we compare the results of the use of these 2 techniques on 150 patients, all performed by the same surgeon. We discuss the pros and cons of PDT and present our experience with the technique compared with surgical tracheotomy (ST). MATERIALS AND METHODS: A prospective study of 75 PDTs and a retrospective study of 75 surgical tracheotomies (ST) were performed at the Department of Otolaryngology-Head and Neck Surgery, Rambam Medical Center, Haifa, Israel. Age, sex, duration of intubation before surgery, time interval between the decision to perform and the performance of tracheotomy, and cost were compared. RESULTS: One hundred fifty tracheotomies were reviewed. The indication for tracheotomy in both groups was prolonged mechanical ventilation. Seven patients were found unsuitable for PDT and underwent ST. Complications included 3 cases of mild postoperative hemorrhage in the ST group, and 1 case of subcutaneous emphysema, 1 case of stomal cellulitis and 2 cases of mild postoperative hemorrhage in the PDT group. The average waiting interval was between 2 to 5 days for ST and 1 to 24 hours for PDT. The intraoperative time for ST was 20 minutes; for PDT, 5 minutes. The cost was 565 dollars for ST and 274 dollars for PDT. CONCLUSIONS: PTD provides an easy, less expensive, and convenient alternative to ST and should be added to the otolaryngologists' armamentarium of surgical airway procedures. The procedure is advantageous for the patient. Complication rates of both techniques are similar and low; however, PDT is a blind technique of obtaining a surgical airway and therefore holds more potential for serious complications. It is our conclusion that this technique is suitable for many, but not all, critical care patients and that the procedure should be performed only by surgeons who are capable of urgently obtaining a surgical airway or exploring the neck should the PDT fail.

Bilateral tinnitus due to middle-ear myoclonus.

Tinnitus is a common otological symptom. Usually it is subjective (perceived only by the patient); very rarely is it objective (heard by both the patient and the examiner) Objective tinnitus due to middle-ear myoclonus is extremely rare, with only a few case reports published in the literature. We present three cases of objective tinnitus caused by middle-ear myoclonus. All patients were cured by tympanotomy with stapedial and tensor tympani tendon section.