The coupled WO3-AgBr nanocatalyst, part II: Synthesis, characterization, and the boosted photocatalytic activity towards metronidazole in an aqueous solution.

The AgBr and WO3 nanoparticles (NPs) were synthesized and coupled, and the coupled AgBr-WO3 binary catalyst, as well as the individual AgBr and WO3 NPs, were then characterized by XRD, FTIR, DRS, and SEM-EDX. XRD results showed the formation of orthorhombic WO3 cubic AgBr crystals. The crystallite sizes of 45, 28, and 45 nm were estimated by the Scherrer formula for the as-prepared AgBr, WO3, and AgBr-WO3 catalysts, respectively. The DRS study estimated band gap energies using both absorption edge wavelengths and the Kubelka-Munk model. The band gap energies of 2.72, 3.06, and 2.92 eV were obtained for the direct electronic transitions of AgBr, WO3, and AgBr-WO3. The ECB (potential position) of AgBr and WO3 were estimated to be 0.01 and 0.52 V, while their EVB values were 2.60 and 3.55 V, respectively. Typical FTIR absorption bands of W‒OH, the W‒O‒W, and AgBr bonds have appeared at 1637 cm-1, 823 (and 766) cm-1, and 1384 cm-1, respectively. The pHpzc of 4 was estimated for the individual and coupled catalysts. In studying the photocatalytic activity of the catalysts in the photodegradation of metronidazole (MNZ) a boosted activity was achieved for the coupled system. This increased activity depends on the maximum AgBr:WO3 mole ratio in a 1:3 mol ratio. Grinding time applied to prepare the coupled catalyst has also varied the photocatalytic activity.

A Comprehensive Review on the Boosted Effects of Anion Vacancy in the Heterogeneous Photocatalytic Degradation, Part II: Focus on Oxygen Vacancy.

Environmental problems, including the increasingly polluted water and the energy crisis, have led to a need to propose novel strategies/methodologies to contribute to sustainable progress and enhance human well-being. For these goals, heterogeneous semiconducting-based photocatalysis is introduced as a green, eco-friendly, cost-effective, and effective strategy. The introduction of anion vacancies in semiconductors has been well-known as an effective strategy for considerably enhancing the photocatalytic activity of such photocatalytic systems, giving them the advantages of promoting light harvesting, facilitating photogenerated electron-hole pair separation, optimizing the electronic structure, and enhancing the yield of reactive radicals. This Review will introduce the effects of anion vacancy-dominated photodegradation systems. Then, their mechanism will illustrate how an anion vacancy changes the photodegradation pathway to enhance the degradation efficiency toward pollutants and the overall photocatalytic performance. Specifically, the vacancy defect types and the methods of tailoring vacancies will be briefly illustrated, and this part of the Review will focus on the oxygen vacancy (OV) and its recent advances. The challenges and development issues for engineered vacancy defects in photocatalysts will also be discussed for practical applications and to provide a promising research direction. Finally, some prospects for this emerging field will be proposed and suggested. All permission numbers for adopted figures from the literature are summarized in a separate file for the Editor.

Synergistic photocatalytic effect of α-Fe2O3-ZnO binary nanocatalyst toward methylene blue: An experimental design study.

Due to the potential ecosystem protection and management applications, searching for highly optimized semiconductor-based solar energy photocatalysts is still a significant challenge. Coupled α-Fe2O3-ZnO nanoparticles were prepared in situ and characterized by various identification techniques such as XRD, SEM-EDX, TEM, DRS, and FT-IR. Its pHpzc was about 8.1. The band gap energies of ZnO, α-Fe2O3, and the coupled α-Fe2O3-ZnO system were 3.22, 2.08, and 2.09 eV, respectively. The boosted photocatalytic activity of the coupled catalysts was designed via the RSM approach, and the optimal RSM conditions were pH 5, 25 min irradiation time, and 0.3 g/L of the α-Fe2O3-ZnO containing 75 % ZnO. The center point conditions' run included 0.5 g/L of the coupled catalyst containing 50 % ZnO, pH 7, and 22.5 min illumination time. The study on scavenger agents showed the highest role of hydroxyl radicals in MB photodegradation by the proposed catalyst.

A comprehensive review on the boosted effects of anion vacancy in the heterogeneous photocatalytic degradation, part I: Focus on sulfur, nitrogen, carbon, and halogen vacancies.

The greenest environmental remediation way is the photocatalytic degradation of organic pollutants. However, limited photocatalytic applications are due to poor sunlight absorption and photogenerated charge carriers' recombination. These limitations can be overcome by introducing anion vacancy (AV) (O, S, N, C, and Halogen) defects in semiconductors that enhance light harvesting, facilitate charge separation, modulate electronic structure, and produce reactive radicals. In continuing part A of this review, in this part, we summarized the recent AVs' research, including S, N, C, and halogen vacancies on the boosted photocatalytic features of semiconductor materials, like metal oxides/sulfides, oxyhalides, and nitrides in detail. Also, we outline the recently developed AV designs for the photocatalytic degradation of organic pollutants. The AV creating and analysis methods and the recent photocatalytic applications and mechanisms of AV-mediated photocatalysts are reviewed. AV engineering photocatalysts' challenges and development prospects are illustrated to get a promising research direction.

Current status of Fe-based MOFs in biomedical applications.

Recently nanoparticle-based platforms have gained interest as drug delivery systems and diagnostic agents, especially in cancer therapy. With their ability to provide preferential accumulation at target sites, nanocarrier-constructed antitumor drugs can improve therapeutic efficiency and bioavailability. In contrast, metal-organic frameworks (MOFs) have received increasing academic interest as an outstanding class of coordination polymers that combine porous structures with high drug loading via temperature modulation and ligand interactions, overcoming the drawbacks of conventional drug carriers. FeIII-based MOFs are one of many with high biocompatibility and good drug loading capacity, as well as unique Fenton reactivity and superparamagnetism, making them highly promising in chemodynamic and photothermal therapy, and magnetic resonance imaging. Given this, this article summarizes the applications of FeIII-based MOFs in three significant fields: chemodynamic therapy, photothermal therapy and MRI, suggesting a logical route to new strategies. This article concludes by summarising the primary challenges and development prospects in these promising research areas.

Current status and prospects of MIL-based MOF materials for biomedicine applications.

This article mainly reviews the biomedicine applications of two metal-organic frameworks (MOFs), MIL-100(Fe) and MIL-101(Fe). These MOFs have advantages such as high specific surface area, adjustable pore size, and chemical stability, which make them widely used in drug delivery systems. The article first introduces the properties of these two materials and then discusses their applications in drug transport, antibacterial therapy, and cancer treatment. In cancer treatment, drug delivery systems based on MIL-100(Fe) and MIL-101(Fe) have made significant progress in chemotherapy (CT), chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy (IT), nano-enzyme therapy, and related combined therapy. Overall, these MIL-100(Fe) and MIL-101(Fe) materials have tremendous potential and diverse applications in the field of biomedicine.

Current status and prospect of ZIF-based materials for breast cancer treatment.

Breast cancer, one of the three most life-threatening cancers in modern times, must be explored for treatments with low side effects and practical efficacy. Metal organic framework materials (MOFs) is made by metal ions as the center for point and organic ligands as a bridge connecting a new type of porous nano-materials, among them, the zinc base zeolite imidazole skeleton material series (ZIFs) because of its excellent biocompatibility and pH slow controlled release ability, is widely used in the tumor microenvironment in basic research and achieved remarkable curative effect. Inspired by this, in this review, we focus on the recent research progress on the application of ZIFs in the treatment of breast cancer, mainly studying the structure of ZIFs such as ZIF-8, ZIF-90 and ZIF-67 and their application in novel therapies for breast cancer treatment, such as targeted drug delivery, photothermal therapy, immunotherapy and gene therapy.We will more fully demonstrate the potential of zif in breast cancer treatment, hoping to provide an avenue for exploring breast cancer treatment.

An experimental design study of photocatalytic activity of the Z-scheme silver iodide/tungstate binary nano photocatalyst.

A binary AgI/ Ag2WO4 photocatalyst was fabricated and characterized by SEM, XRD, UV-Vis DRS, and FT-IR. It was then used to photodegrade sodium ceftriaxone (CTX) in an aqueous solution. The band gap energies of 2.95, 2.78, and 2.62 eV were obtained by the Kubelka-Munk model for Ag2WO4, AgI, and AgI/Ag2WO4 catalysts. The samples have pHPZC values of 6.9, 4.2, and 6.6, respectively. The synergistic photocatalytic activity of the coupled system depended on the AgI:Ag2WO4 mole ratio and grinding time (optimums:mole ratio of 4:1 and time 30 min). The experimental design was used for optimizing the conditions and a quadratic model well-processed the data based on the model F value of 131.87 > F0.05,14,13 = 2.55 and LOF F value of 0.78 < F0.05,10,3 = 8.78. The optimized RSM run included the irradiation time of 85 min, 3.5 mg/L of CTX sample at pH 9, and a catalyst dose of 1.0 g/L. Under the optimized conditions, about 63% of CTX molecules were photodegraded. In the study of the scavenging agents, the direct Z-scheme mechanism accumulated electrons in the CB-AgI and the holes in the VB-Ag2WO4 level, as stronger reducing and oxidizing centers than the accumulated electrons and holes of the type (II) heterojunction mechanism. Compared to a CTX oxidation potential of about 0.06 V, the direct Z-scheme mechanism is more favorable to reduce or oxidize it.

A comparison of adsorption capacity of several synthesis methods of cellulose-based absorbent towards Pb(II) removal: Optimization with response surface methodology.

The effects of various synthesis methods of a novel biodegradable magnetically recyclable cellulose-based adsorbent (a magnetized modified silica aerogel) on Pb(II) removal efficiency were studied. QSM (quince seed mucilage) was modified via hydrothermal and ultrasonic modes. Oven-drying and freeze-drying procedures were then used to obtain the final adsorbents. The adsorbents were named A1 to A4 and B1 to B4, depending on the synthesis and drying techniques. XRD, FTIR, BET, and SEM are characterization techniques for identifying the adsorbents. Average crystallite sizes of 15.5, 8.3, 10.9, and 2.7 nm were obtained for A1, A2, A3, and A4 samples (Scherrer formula). SEM image confirmed a Sticky bullets-like morphology. The pHpzc values of 3.4, 6.0, and 4.1 were also determined for Fe-silica aerogel, Fe-QSM, and Fe-silica aerogel-QSM samples. The highest adsorption efficiency of the A2 adsorbent towards Pb(II) cations was followed via the experimental design by the RSM (response surface methodology) approach. ANOVA results showed model F value 185 (>F0.05, 14, 15 = 2.42) and LOF F-value of 0.3831 (

A Novel Platform of MOF for Sonodynamic Therapy Advanced Therapies.

Metal-organic frameworks (MOFs) combined with sonodynamic therapy (SDT) have been introduced as a new and efficient treatment method. The critical advantage of SDT is its ability to penetrate deep tissues and concentrate energy on the tumor site to achieve a non-invasive or minimally invasive effect. Using a sonosensitizer to generate reactive oxygen species (ROS) under ultrasound is the primary SDT-related method of killing tumor cells. In the presence of a sonosensitizer, SDT exhibits a more lethal effect on tumors. The fast development of micro/nanotechnology has effectively improved the efficiency of SDT, and MOFs have been broadly evaluated in SDT due to their easy synthesis, easy surface functionalization, high porosity, and high biocompatibility. This article reviews the main mechanism of action of sonodynamic therapy in cancer treatment, and also reviews the applications of MOFs in recent years. The application of MOFs in sonodynamic therapy can effectively improve the targeting ability of SDT and the conversion ability of reactive oxygen species, thus improving their killing ability on cancer cells. This provides new ideas for the application of micro/nano particles in SDT and cancer therapy.

Evaluation of the photodegradation activity of bismuth oxoiodide/bismuth sub-carbonate nanocatalyst: Experimental design and the mechanism study.

In this study, a binary BiOI/(BiO)2CO3 catalyst was prepared and used for sulfasalazine (SSZ) photodegradation in an aqueous phase. The semiconductors were identified by XRD, SEM-EDX, and UV-Vis diffuse reflectance spectroscopy (DRS) methods. Applying the Kubelka-Munk model on DRS results, the band gap energies of 2.09, 3.5, and 2.07 eV were obtained for BiOI, (BiO)2CO3, and BiOI/(BiO)2CO3 samples. pHpzc values of 6.3, 10.1, and 8.1 were estimated for BiOI, (BiO)2CO3, and BiOI/(BiO)2CO3, respectively. After observing the boosted photocatalytic activity by the coupled system, the interaction effects of the influencing variables in SSZ photodegradation were evaluated via the response surface methodology (RSM) approach. The optimal RSM-run conditions were 8.5 ppm SSZ at pH 8, which contained 0.28 g/L of the BiOI/(BiO)2CO3 catalyst and 29 min illumination time, resulting in 87% SSZ photodegradation. The effects of some scavenging agents were also studied to elucidate the relative roles of the reactive species in the SSZ photodegradation by the proposed catalyst, that is, hydroxyl radicals ∼ photoinduced electrons > superoxide radicals ∼ photoinduced holes. The proposed catalyst retained good activity after 5 successive reusing runs.

Fluorescence detection platform of metal-organic frameworks for biomarkers.

Sensitive and selective detection of biomarkers is crucial in the study and early diagnosis of diseases. With the continuous development of biosensing technologies, fluorescent biosensors based on metal-organic frameworks have attracted increasing attention in the field of biomarker detection due to the combination of the advantages of MOFs, such as high specific surface area, large porosity, and structure with tunable functionality and the technical simplicity, sensitivity and efficiency and good applicability of fluorescent detection techniques. Therefore, researchers must understand the fluorescence response mechanism of such fluorescent biosensors and their specific applications in this field. Of all biomarkers applicable to such sensors, the chemical essence of nucleic acids, proteins, amino acids, dopamine, and other small molecules account for about a quarter of the total number of studies. This review systematically elaborates on four fluorescence response mechanisms: metal-centered emission (MC), ligand-centered emission (LC), charge transfer (CT), and guest-induced luminescence change (GI), presenting their applications in the detection of nucleic acids, proteins, amino acids, dopamine, and other small molecule biomarkers. In addition, the current challenges of MOFs-based fluorescent biosensors are also discussed, and their further development prospects are concerned.

Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications.

Metal-phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing a crucial role in tumor treatment. As the most common subclass of the MPNs family, Fe-based MPNs are most frequently used in chemodynamic therapy (CDT) and phototherapy (PTT), where they are often used as nanocoatings to encapsulate drugs, as well as good Fenton reagents and photosensitizers to improve tumor therapeutic efficiency substantially. In this review, strategies for preparing various types of Fe-based MPNs are first summarized. We highlight the advantages of Fe-based MPNs under the different species of polyphenol ligands for their application in tumor treatments. Finally, some current problems and challenges of Fe-based MPNs, along with a future perspective on biomedical applications, are discussed.

CaTiO3/g-C3N4 heterojunction-based composite photocatalyst: Part I: Experimental design, kinetics, and scavenging agents' effects in photocatalytic degradation of gemifloxacin.

A critical, challenging environmental issue is explored pollution of water supplies by discharging industrial/pharmaceutical/hospital/urban wastewaters into the aquatic environment. These needs introducing/developing novel photocatalysts/adsorbents/procedures for removing or mineralizing various pollutants in wastewater before discharging them into marine environments. Further, optimizing conditions to achieve the highest removal efficiency is an important issue. In this study, CaTiO3/g-C3N4 (CTCN) heterostructure was synthesized and characterized by some identification techniques. The simultaneous interaction effects of the experimental variables on the boosted photocatalytic activity of CTCN in the degradation of gemifloxcacin (GMF) were studied in RSM design. The optimal values for four parameters were: catalyst dosage: 0.63 g L-1, pH: 6.7, CGMF: 1 mg L-1, and irradiation time: 27.5 min, with approximately 78.2% of degradation efficiency. The quenching effects of the scavenging agents were studied to show the reactive species' relative importance in GMF photodegradation. The results illustrate that the reactive •OH plays a significant role, and the electron plays a minor role in the degradation process. The direct Z-scheme mechanism better described the photodegradation mechanism due to the great oxidative and reductive abilities of prepared composite photocatalysts. This mechanism is an approach to efficiently separating photogenerated charge carriers and improving the CaTiO3/g-C3N4 composite photocatalyst activity. The COD has been performed to study the details of the mineralization of GMF. The pseudo-first-order rat (from the Hinshelwood model) constants of 0.046 min-1 (t1/2 = 15.1 min) and 0.048 min-1 (t1/2 = 14.4 min) were respectively obtained from the GMF photodegradation data and COD results. The prepared photocatalyst retained its activity after five reusing runs.

Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs.

Cancer has become the second leading reason for death in the world. Still, cancer therapy development is exceptionally challenging because the tumor microenvironment is very complex, and individual tumors are very different. In recent years, researchers have found that platinum-based drugs in the form of metal complexes can effectively solve tumor resistance. In this regard, metal-organic frameworks (MOFs) as suitable carriers with high porosity are also exceptional in the biomedical field. Therefore, this article reviews the application of platinum as an anticancer drug and the composite anticancer properties of platinum and MOF materials and prospects for its future development, which provides a new direction for further research in the biomedical field.

A Z-scheme CdS/Ag3PO4 catalyst: Characterization, experimental design and mechanism consideration for methylene blue.

Due to the explosive use of Azo dyes in various industries such as textiles, discharging these industrial effluents into the environment critically polluted water supplies. Accordingly, constructing/developing novel binary catalysts to diminish the pollution extent of such effluents before discharging into environment is an excellent issue in environmental chemistry. Here, a binary CdS/ Ag3PO4 was constructed, and its boosted photocatalytic activity was proven against methylene blue (MB), as a model dye pollutant. The Wurtzite CdS and Ag3PO4 cubic crystal nanoparticles were synthesized and coupled mechanically. The binary sample's lowest photoluminescence (PL) results confirm a higher e/h separation. DRS results confirmed a decreased energy gap for the coupled system. The semiconductors' VB and CV potentials were calculated and used for constructing of Z-scheme mechanism. The photocatalytic activity was followed via an experimental design approach. The model F-value of 89.75 > F0.05,14,13 = 2.42 and LOF F-value of 6.57 < F0.05,10, 3 = 8.79 reveal that the model well processed data. The optimal run conditions were CMB: 5 ppm, Catalyst dose: 1 g/L, pH: 3.25, and irradiation time: 139 min, at which 85% of MB molecules were degraded. Based on the trend of ascorbic acid > isopropanol > formic acid ≈ nitrate obtained for the scavengers' importance in decreasing the photocatalyst activity, superoxide radicals had the highest effect in MB degradation and then •OH. The results showed the direct Z-scheme has the main effect on MB degradation by the binary sample.

Cefotaxime degradation by the coupled binary CdS-PbS: characterization and the photocatalytic process kinetics.

Increased water pollution due to discharging industrial/urban/hospital wastewater has been adopted to introduce/develop novel removal techniques/catalyst/adsorbent. The hexagonal (wurtzite) CdS and the cubic PbS nanoparticles (NPs) were synthesized, coupled, and supported onto clinoptilolite NPs (CNP). Then, the sample was characterized by X-ray powder diffraction (XRD), diffuse reflectance spectroscopy (DRS), Fourier transform infrared (FTIR), and a scanning electron microscope equipped with an energy dispersive X-ray analyzer (SEM-EDX) techniques. The average crystallite size for CdS NPs, PbS NPs, CNP, and CdS-PbS/CNP samples was obtained at about 24, 36, 27, and 14 nm using the Scherrer formula value of nanometer, by the W-H formula, 31, 17, 39, and 51, respectively. Only a detectable slope can be observed from the DRS spectra for CdS NPs at 591 nm corresponding to an Eg value of 2.1 eV. PbS NPs have a broad abruption peak that begins from the visible region and extends to the IR region of the light. A boosted photocatalytic activity of the supported binary catalysts towards cefotaxime (CT) was reached. An apparent first kinetic model was reached with a k-value of 0.021 min-1 corresponding to the t1/2 value of 33 min. A decreased COD trend for the photodegraded CT solutions was reached, and the chemical oxygen demand (COD) results in the Hinshelwood model showed a k-value of 0.016 min-1, corresponding to a t1/2 value of 43 min.

Cerium oxide: synthesis, brief characterization, and optimization of the photocatalytic activity against phenazopyridine in an aqueous solution.

Water pollution by antibiotics is a global crisis, and its risk is critically more severe due to the explosive use of these drug compounds. A critical effective removal method to diminish this risk is heterogeneous photocatalysis and optimizing the conditions to reach higher mineralization efficiency. CeO2 anoparticles (NPs) were synthesized and characterized by X-ray diffraction (XRD), UV-Vis diffuse reflection spectroscopy (DRS), and Fourier transform infrared spectroscopy (FTIR) techniques. A cubic structural crystallite phase was detected that had crystallite sizes of 17.9 and 16.7 nm estimated by the Scherrer and Williamson-Hall models. A typical FTIR absorption band for the Ce-O stretching absorption has appeared at 554 cm-1. Based on DRS data and the Kubelka-Munk and Tauc models, Eg values of 2.80, 3.06, 3.12, and 3.13 eV were obtained for n-values of 1/2, 2, 3/2, and 3, respectively. pHpzc of CeO2 NPs was about 5.7. The direct photolysis and surface adsorption processes have no critical role in phenazopyridine (PP) removal by appearing with 2.7 and 6.7% removal efficiencies, respectively. Due to the highest photocatalytic activity of CeO2 NPs toward PP, the effects of the critical operating variable on the activity were evaluated, and the optimal conditions were as catalyst dose, 0.7 g/L; pH, 6; irradiation time, 90 min; and CPP, 20 ppm. The Hinshelwood kinetics equation plot was y = - 6.6442 - 0.4677x (r2 = 0.9296), in which its slope as the rate constant of the photodegradation process was 0.4677 min-1 (corresponding to a t1/2 value of 1.48 min).

The boosted photocatalytic effects of a zeolite supported CdS towards an antibiotic model pollutant: a brief kinetics study.

In recent decades, increased world population and industrial activities explosively polluted our environment, especially the aquatic resources. This requires introducing/developing novel methods to decrease the pollution extent of such resources. Here, the hexagonal (wurtzite) CdS nanoparticles (NPs) were synthesized and supported onto ball-mill prepared clinoptilolite NPs (CNP). Samples were briefly characterized by X-ray powder diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope equipped with an energy dispersive X-ray analyzer (SEM-EDX), and diffuse reflectance spectroscopy (DRS) techniques. The average crystallite size for CdS NPs and CdS-CNP samples was estimated to be about 9.0 nm and 12.3 nm (from the Scherrer formula) and about 19.7 and 17.5 nm (from the Williamson-Hall model), respectively. From the DRS spectra, the absorption wavelengths of 595 and 546 nm correspond to band gap energies of 2.08, and 2.27 eV was obtained for CdS NPs and CdS-CNP samples. The samples were then used in the photodegradation of cefotaxime (CT), and the results showed a boosted photocatalytic activity for CdS-CNP rather than CdS NPs. The photodegradation process obeyed the pseudo-first-order kinetic model, and the CdS and CdS-CNP catalysts obtained the k-values of 0.013 min-1 and 0.023 min-1. When the photodegraded CT solutions were used in COD experiments, the k-values changed to 0.011 min-1 and 0.029 min-1, respectively. The zeolite support is an eco-friendly natural zeolite with abundant deposits in Iran that yields a cost-effective method.

Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.

This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method. The effects of three variables gluten (37%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated. The results confirmed that gluten is compatible with Persian gum and Guar gum. Optimization was determined, and then the morphological properties and interaction of the film components were investigated with SEM and FTIR, respectively. Results showed that all three variables significantly affected the films' mechanical and physical properties (P < 0.05). Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films. Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum. Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05). The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w). Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups. The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films. High amounts of gum reduced the thickness of the film.