RESUMO
The paraneoplastic amphiphysin(+) stiff-person syndrome (SPS) has so far only been described in women with breast adenocarcinoma. Here, we describe the rare case of a female patient with antiamphiphysin(+) SPS due to small cell cancer of the lung.
Assuntos
Carcinoma de Células Pequenas/complicações , Neoplasias Pulmonares/complicações , Proteínas do Tecido Nervoso/imunologia , Rigidez Muscular Espasmódica/etiologia , Autoanticorpos/sangue , Carcinoma de Células Pequenas/imunologia , Eletromiografia , Feminino , Humanos , Neoplasias Pulmonares/imunologia , Pessoa de Meia-Idade , Rigidez Muscular Espasmódica/imunologiaRESUMO
Listeriosis is a bacterial infection with Listeria monocytogenes mostly affecting immunocompromised patients. In every fourth case, the CNS is involved, usually as meningoencephalitis. This case report of an immunocompetent woman represents the first one of neurolisteriosis initially presenting as cervical myelitis and progressing to supratentorial areas of the brain. Diagnosis was based on universal polymerase chain reaction from a cortical brain biopsy, followed by sequencing of the amplified rDNA gene. Under antibiotic treatment with gentamycin and ampicillin, the patient slowly recovered and has been improving ever since.