1.
Ann N Y Acad Sci
; 973: 70-4, 2002 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12485836
RESUMO
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes. Consistent with this finding we show PI3K-dependent Bad-inactivation by binding to 14-3-3 proteins in response to GDNF. Using differential display techniques we detected several cDNA clones differentially expressed after treatment with GDNF or 6-OHDA.