D-tryptophan, an eco-friendly natural, safe, and healthy compound with antimicrobial activity against food-borne pathogens: A systematic review.

Recently, the use of D-amino acids as food preservatives has attracted considerable attention because these natural compounds do not have adverse effects on human health. In addition, D-amino acids such as D-tryptophan can reduce the harmful effects of other treatments. For instance, the use of D-tryptophan in food reduces the requirement for high temperatures and their damaging effects on nutrients such as proteins and vitamins. The purpose of this systematic review was to investigate the antimicrobial effect of D-tryptophan on food-borne pathogens in vitro and in food models. To identify related studies, scientific digital databases such as PubMed, Science Direct, and Google Scholar were searched from January 2000 to February 2023. The results of the studies showed that when D-tryptophan was used with other stresses such as using different salt concentrations, refrigeration, or high temperatures, it showed significant antimicrobial effects on Gram-positive and Gram-negative food-borne pathogens, and antibiofilm impacts were also observed with D-tryptophan. Since studies have shown that the antimicrobial activity of D-tryptophan depends on several factors, including the pathogen strain, the type of stress, and the concentration of D-tryptophan, and every article has focused on one of these factors, there is a need for a systematic review that summarizes and concludes the effect of all these factors on the antimicrobial activity of D-tryptophan against food-borne pathogens.

Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils.

This review highlights the effect of combining bioactive agents, especially nanoparticles, in carrageenan coating to increase the quality and stability of foods. This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides, proteins, and lipids. They confer some beneficial effects on foods, such as improvement of appearance and texture, reducing the amount of moisture loss and oxidation, prevention of the release of gases and control of microbial growth, delaying ripening and adverse changes in color and taste, improvement of nutritional value, and increasing the shelf life of the product. These improvements lead to the prevention of food spoilage and increase the shelf life of various foods. In addition, nanomaterials and food additives such as antimicrobial and antioxidant agents, flavorings, and colors can be incorporated into food coatings and films to expand their applications. Nanotechnology can be applied in coatings and food films using nanoparticles. However, more research is still needed to gather information about coating formulations, especially when new materials are incorporated into them.

Effect of alginate coating activated by solid lipid nanoparticles containing Zataria multiflora essential oil on chicken fillet's preservation.

The current study aimed to assess the chemical, microbial, and sensory properties of Solid Lipid Nanoparticles (SLNs) in chicken fillets stored at 4 ± 1 °C for 12 days. As a result, the optimized ZEO-SLNS sample exhibited a spherical morphology with a droplet size of 251.51 ± 1.11 nm and a PDI of 0.34 ± 0.01 under transmission electron microscopy (TEM). The encapsulation efficiency (EE) and zeta potential were approximately 55.4 % and -20.87 ± 1.39 mV, respectively. Furthermore, encapsulating ZEO in SLNS enhanced antibacterial and antioxidant activity compared to pure ZEO. As a result, the application of alginate-loaded ZEO-SLNS extended the storage time of fresh chicken fillets. Thus, the application of this edible coating showcased a remarkable ability to substantially decelerate both microbial and chemical changes in chicken fillets during cold storage conditions. This finding underscores the potential of the edible coating as an effective means to enhance the safety and quality of chicken products.

Application of novel metal organic framework-deep eutectic solvent/molecularly imprinted polymer multiple monolithic fiber for solid phase microextraction of amphetamines and modafinil in unauthorized medicinal supplements with GC-MS.

The goal of this research is the development of multiple monolithic fiber-solid phase microextraction (MMF-SPME) using a new integrated fiber for the determination of amphetamine derivatives and modafinil from unauthorized medicinal supplements. For this purpose, a monolithic fiber of metal organic framework MIL-Al (53)-deep eutectic solvent (DES)/molecularly imprinted polymers (MOF-DES/MIP) was synthesized. To find optimum microextraction conditions gas chromatography-mass spectrometer (GC-MS) was used and the influences of effective variables were investigated using one factor at a time method. After that, the significant variables were optimized using a Box-Behnken design (BBD) combined with a desirability function (DF). Under optimized conditions (desorption solvent=1500 µL of 1-octanol, pH=3.5, extraction time=35 min, [NaCl]=0% w/v and stirring rate=600 rpm), calibration graphs of analytes were linear in a concentration range of 0.1-400 µg L-1 with correlation coefficients > 0.9966. Limits of detection and quantification were in the ranges of 0.023-0.033 µg L-1 and 0.088-0.113 µg L-1, respectively. This procedure was successfully employed in determining target analytes in spiked and unspiked unauthorized medicinal supplement samples with recoveries ranging from 95.14 to 104.63%.

Methylcellulose/chitosan nanofiber-based composites doped with lactoferrin-loaded Ag-MOF nanoparticles for the preservation of fresh apple.

Increasing demand for high-quality fresh fruits and vegetables has led to the development of innovative active packaging materials that exhibit controlled release of antimicrobial/antioxidant agents. In this study, composite biopolymer films consisting of methylcellulose (MC) and chitosan nanofibers (ChNF) were fabricated, which contained lactoferrin (LAC)-loaded silver-metal organic framework (Ag-MOF) nanoparticles. The results indicated that the nanoparticles were uniformly distributed throughout the biopolymer films, which led to improvements in tensile strength (56.1 ± 3.2 MPa), thermal stability, water solubility, swelling index, water vapor barrier properties (from 2.2 ± 2.1 to 1.9 ± 1.9 × 10-11 g. m/m2. s. Pa), and UV-shielding effects. The Ag-MOF-LAC2% films also exhibited strong and long-lasting antibacterial activity against E. coli (19.8 ± 5.2 mm) and S. aureus (20.1 ± 3.2 mm), which was attributed to the slow release of antimicrobial LAC from the films. The composite films were shown to maintain the fresh appearance of apples for at least seven days, which was attributed to their antimicrobial and antioxidant activities. Consequently, these composite films have the potential in the assembly of innovative active packaging materials for protecting fresh fruits and vegetables. However, further work is required to ensure their safety and economic viability.

Gentisic acid mitigates gentamicin-induced nephrotoxicity in rats.

The current investigation was considered to evaluate the beneficial effects of gentisic acid (GA) on gentamicin (GEN)-induced nephrotoxicity in rat kidneys through assessment of oxidative stress, inflammatory cytokines, and histopathological changes. Rats were split into five equal groups. Rats were treated with GA (25, 50, and 100 mg/kg/day, p.o.) for 14 consecutive days and GEN (100 mg/kg, i.p.) was administrated from day 8 to day 14 of the experiment. On the 15th day, blood samples were collected to determine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine (Cr) levels. Malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor-alpha (TNF-α) and interleukin-1ß (IL-1ß), and nitric oxide (NO) levels and the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were assessed in the renal tissue. Histopathological evaluations were done to confirm the biochemical results. GEN increased the levels of NGAL, KIM-1, BUN, and Cr in serum as well as MDA, NO, GSH, TNF-α, and IL-1ß in renal tissue. Moreover, GEN administration reduced the activity of CAT, SOD, and GPx in renal tissue. Nonetheless, the administration of GA before and alongside GEN mitigated these deleterious effects. In conclusion, GA has a beneficial effect on biochemical, inflammatory, and oxidative stress indices against GEN-induced nephrotoxicity.

Effect of feed trace elements on eggs of five strains of laying hens and their health risk assessment.

BACKGROUND: Trace elements are essential for human nutrition, and their deficiencies or excesses are strongly associated with several diseases, such as cardiovascular ones. OBJECTIVES: The current cross-sectional study investigated the concentration of essential trace elements (copper, non-metal selenium, iron, zinc, cobalt and manganese) in eggs and diets of five strains of laying hens. METHODS: The yolk and albumen were analysed separately, and wet preparation was carried out following inductively coupled plasma-optical emission spectrometry detection. The target hazard quotients (THQs) for the non-carcinogenic disease were calculated by the United States environmental protection agency (USEPA) method. RESULTS: The highest concentrations of selenium, zinc and manganese were found in egg yolks of native hens (0.76, 44.22 and 6.52 mg/kg, respectively). The highest amounts of copper and cobalt were recorded in the egg yolk of Lohman (2.07 and 0.023 mg/kg, respectively). On the other hand, the egg yolk of Bovans contained the highest amount of iron (57.46 mg/kg). CONCLUSION: Overall, the potential health risks were minimal, and the consumption of eggs was generally safe.

Electrospinning of Nanofibers Incorporated with Essential Oils: Applications in Food.

Nowadays, modern food preservation techniques have emerged in the last decade. Recently, a combination of nanotechnology and active packaging has allowed the incorporation of bioactive compounds, such as essential oils, into nanoscale electrospun fibers. This phenomenon provides a new horizon in food safety and preservation. The incorporation of essential oils into electrospun nanofibers can extend the duration of antimicrobial and antioxidant activity of essential oils, which subsequently leads to longer shelf life, better preservation, and superior quality of food. In the current paper, the essential oils incorporated into nanofibers have been reviewed. The fabrication of nanofibers is usually carried out using different substances by applying various manufacturing methods, including needleless and needle-based electrospinning techniques. In this study, an emphasis on the antioxidant and antibacterial effects of electrospun nanofibers loaded with essential oils and their application in food models has been laid. Nevertheless, other challenges associated with using nanofibers incorporated with essential oils, such as their impact on organoleptic properties, cytotoxicity, and durability, have been discussed to achieve a holistic view of applying the electrospinning techniques in the food industry.

Impact of alginate coating combined with free and nanoencapsulated Carum copticum essential oil on rainbow trout burgers.

Carum copticum essential oil (CEO) is known as a valuable active food and pharmaceutical ingredient with antimicrobial and antioxidant activities. Solid lipid nanoparticles incorporated with CEO can overcome their limitations, namely low physicochemical stability and water solubility. In the current study, the antimicrobial and antioxidant activity of free and nanoencapsulated CEO were measured. The results revealed that although the nanoparticles of CEO had higher DPPH radical scavenging activity compared to free CEO, the antimicrobial activity of free CEO toward Escherichia coli and Listeria monocytogenes was higher than nanoparticles. Fish burger samples coated with free and nanoencapsulated CEO and stored for 12 days at 4°C. Alginate coating without CEO was considered as a control sample. The mean zeta potential, particle size, and polydispersity index (PDI) of nanoparticles were 19.18 ± 0.9 mV, 286.5 ± 18.2 nm, and 0.32 ± 0.01, respectively. The results revealed that lipid oxidation, microbial growth, and production of total volatile basic nitrogen in fish burger samples coated with alginate enriched with nanoencapsulated CEO were lower than free CEO. The main volatile compounds of CEO were para-cymene, γ-terpinene, and thymol, which were responsible for the antioxidant and antimicrobial activity of CEO. The data obtained by the current study suggest the application of alginate coating with CEO in form of nanoparticle to enhance fish burgers' shelf life stored at 4°C.

The Global Burden of Viral Food-borne Diseases: A Systematic Review.

BACKGROUND: The objectives of this paper were to determine the overall number of diseases, deaths, and Disability-Adjusted Life Years (DALYs) caused by viral foodborne diseases (FBDs). An extensive search scheme was performed using several search terms; disease burden, foodborne disease, and foodborne viruses. METHODS: The obtained results were subsequently screened based on title, abstract, and, finally, full text. Relevant evidence on human food-borne virus diseases (prevalence, morbidity, and mortality) was selected. Of all viral foodborne diseases, norovirus was the most predominant one. RESULTS: The incidence rates of norovirus foodborne diseases ranged from 11 to 2,643 cases in Asia and from 418 to 9,200,000 in the USA and Europe. Norovirus had a high burden of disease Disability-Adjusted Life Years (DALYs) compared with other foodborne diseases. North America was reported as a country with a high burden of disease (DALYs = 9900) and illness costs. DISCUSSION: High variability of prevalence and incidence were observed in different regions and countries. Food-borne viruses pose a considerable burden on poor health throughout the world. CONCLUSION: We suggest the addition of foodborne viruses to the global burden of disease, and relevant evidence can be used to improve public health.

Impact of microencapsulated Ziziphora tenuior essential oil and orange fiber as natural-functional additives on chemical and microbial qualities of cooked beef sausage.

The aim of the current study was to investigate the suitability of Ziziphora tenuior essential oil (ZEO) as a preservative. For this purpose, the effect of free and microencapsulated ZEO, combined with orange fiber, was determined on the chemical and microbial qualities of cooked beef sausage. In this study, modified starch was used for encapsulation of essential oil, and subsequently, 0.5% ZEO and 1% orange fiber were used for preparing cooked beef sausages during 60 days of storage at 4°C. To assess the microbial quality of samples, total viable count (TVC), psychrophilic count (PSY), and lactic acid bacteria (LAB) were analyzed. Furthermore, peroxide value (PV) and thiobarbituric acid reactive substances (TBARS) were tested to examine lipid oxidation. The most components of ZEO were pulegone (47.12%), isomenthone (14.57%), and 1,8-cineole (12.84%) according to GC-MS analysis. The reducing power, DPPH radical scavenging activity, MIC, and MBC of ZEO were 16.44 (EC50), 8.36 (IC50), 0.625-2.5, and 1.25-5 mg/ml, respectively. Moreover, sausage containing 0.5% microencapsulated ZEO in combination with 1% orange fiber showed the best results with the following values (p ≤ .05): TVC (3.69 log CFU/g), PSY (3.51 log CFU/g), LAB (3.1 log CFU/g), PV (10.41 meq/kg lipid), and TBARS (3.1 mg MDA/kg). This is due to the antimicrobial and antioxidant properties of microencapsulated essential oil. Therefore, the results of the present study can be applied in the meat industries as a new natural preservation method.

Probiotic bacteria from 10 different traditional Iranian cheeses: Isolation, characterization, and investigation of probiotic potential.

In this study, 10 different traditional Iranian cheeses, which are still consumed by people in rural areas of Iran, were examined to isolate new strains of probiotic bacteria. Isolated bacteria were identified by 16s rRNA gene amplification and subjected to series of in vitro tests to find out their probiotic potential. A total of 2345 colonies were collected and 465 of them were confirmed as lactic acid bacteria (LAB), of which Lactiplantibacillus plantarum, Lactobacillus bulgaricus, and Lacticaseibacillus casei were the top three isolated bacteria. Among the different species of LAB isolated in this study, Lactip. plantarum was the most isolated species, and seven isolates had the significant criteria for being a probiotic strain than other isolates indicating the most adaptable properties of this species. Lactiplantibacillus plantarum was the most resistant bacteria in the bile resistance test and was also the most durable bacteria in gastrointestinal conditions, for example, acidic environment (pH = 2.5) and trypsin. In contrast, Lacticaseibacillus casei was the most susceptible bacterial strain. Lactobacillus rhamnosus showed the most antibacterial effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. This study showed that probiotic strains isolated from local cheeses could be considered as suitable biopreservatives and used as specific starter cultures for the production of functional cheeses.

WITHDRAWN: Electrospinning of Nanofibers Incorporated with Essential Oils: Applications in Food

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The role of the gut microbiota and nutrition on spatial learning and spatial memory: a mini review based on animal studies.

The gut-brain axis is believed to constitute a bidirectional communication mechanism that affects both mental and digestive processes. Recently, the role of the gut microbiota in cognitive performance has been the focus of much research. In this paper, we discuss the effects of gut microbiota and nutrition on spatial memory and learning. Studies have shown the influence of diet on cognitive capabilities such as spatial learning and memory. It has been reported that a high-fat diet can alter gut microbiota which subsequently leads to changes in spatial learning and memory. Some microorganisms in the gut that can significantly affect spatial learning and memory are Akkermansia muciniphila, Bifidobacterium, Lactobacillus, Firmicutes, Bacteroidetes, and Helicobacter pylori. For example, a reduction in the amount of A. muciniphila in the gut leads to increased intestinal permeability and induces immune response in the brain which then negatively affects cognitive performances. We suggest that more studies should be carried out regarding the indirect effects of nutrition on cognitive activities via alteration in gut microbiota.

Determination of heavy metals (lead, cadmium, arsenic, and mercury) in authorized and unauthorized cosmetics.

Aim: The present study evaluates lead, cadmium, arsenic, and mercury contamination in lipsticks, mascara, eye shadow, and eyebrow pencils, and compares the amounts of these toxic elements in both legal and contraband products. Background: The presence of heavy metals in cosmetics is of major concern, and requires constant monitoring to ensure the safety of consumers. Cosmetics contaminated with heavy metals can lead them to accumulate in the skin, while the further migration of these toxic elements to blood vessels can cause subsequent difficulties. Material and methods: The graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Direct Mercury Analyzer (DMA) techniques were used. Results: The data indicate that the lead content in the products did not exceed the acceptable limit of the Federal Office of Consumer Protection and Food Safety of Germany (BVL), and that the cadmium values in all products were significantly lower than the limit set by the BVL. The arsenic contents of lipsticks, eye shadows, and eyebrow pencils was significantly higher than the BVL standard, while the mercury content was far below the BVL standards, so there seems to be no concern associated with this toxic element. Legal cosmetics showed better results, except for mascara, which had higher amounts of arsenic than contraband. The higher contents of arsenic in contraband eye shadows and eyebrow pencils is an issue that should be taken into considerations by the relevant authorities. Conclusion: The authors suggest further analysis of the toxic elements in cosmetics and better monitoring of both imported and contraband cosmetics. Moreover, consumers' knowledge of the potential risks of the frequent application of cosmetic products should be improved.

Effect of inulin-type fructans in patients undergoing cancer treatments: A systematic review.

BACKGROUND AND OBJECTIVE: Current studies give us inconsistent results regarding the inulin consumption in cancer patients. The results of to-date studies are summarized in this systematic review. METHODS: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL Science direct, Google scholar, Scopus and Cochrane were searched. Cochrane Collaboration's 'Risk of Bias' tool was used to assess the quality of included articles. RESULTS: Our search yielded 2652 studies after the elimination of duplicates. Three randomized controlled trials (RCTs), reporting results from 197 patients, were eligible for inclusion in the present systematic review. Risk of bias in these studies was assessed as high and moderate. CONCLUSION: The available evidence is inconclusive regarding the effect of inulin and oligofructose on cancer outcomes. Nonetheless, possible inulin positive effects including improved stool consistency after abdomen radiotherapy and increased stool butyrate content which is involved in controlling tumor cells proliferation and apoptosis should not be denied. Further research is needed in this area before strong conclusions can be drawn.