[Effects of coal tar on hematological parameters in experimental tuberculosis]. / Vliianie kamennougol'noi smoly na gematologicheskie pokazateli pri éksperimental'nom tuberkuleze.

Guinea pigs were injected with coal tar (CT) (intratracheally, 25 mg per animal once a week or a month for 2 or 8 months, respectively), then they were infected with MBT (H37Rv, 0.1 mg, subcutaneously). There were changes in hematological responses to MBT changes (in the context of the cell composition of bone marrow and peripheral blood), their pattern was associated with the mode of exposure to CT preceding MBT inoculation. The greatest differences were found in the responses of bone marrow lymphopoiesis and peripheral lymphocytes upon both exposures to CT. On greater exposure to CT (once a week) the changes in the blood system indicated that CT had an adverse effect on the course of experimental tuberculosis, while on lesser exposure (once a month), the effect of CT was more favourable.

[Morphological features of tissue reactions in combined treatment of experimental tuberculosis induced by xenobiotics]. / Morfologicheskie osobennosti tkanevykh reaktsii pri kompleksnoi terapii éksperimental'nogo tuberkuleza, razvivshegosia na fone predvaritel'nogo vozdeistviia ksenobiotikov.

The trend to aggravated running and contribution of air pollution of large industrial centers with polycyclic aromatic hydrocarbons (PAH) to tuberculosis onset and progress dictate the necessity of the search for new treatment methods. The authors made an attempt to treat experimental tuberculosis with sodium glutamate and isoniazide under chronic exposure to PAH dust. Sodium glutamate especially in combination with isoniazide produces a good effect enhancing granulomatous reactions fibroplastic processes in the foci of specific inflammation. Sodium glutamate is thought an effective pathogenetic treatment of tuberculosis.

[State of immunobiological reactivity of experimental animals to tuberculosis and exposure to coal tar]. / Sostoianie immunobiologicheskoi reaktivnosti éksperimental'nykh zhivotnykh pri tuberkuleznoi infektsii i vozdeistvii kamennougol'noi smoly.

Among most common environmental factors microflora and xenobiotics are capable of changing immunological resistance of human and animal body. Combined action of these factors on the animals has never been studied. Guinea pig experiments showed that M. tuberculosis can significantly change immunogram of the animals exposed for a long time to coal tar. On the one hand, the effect may be negative, but on the other, in certain conditions coal tar enhanced guinea pig's resistance to M. tuberculosis.