RESUMO
CASE PRESENTATION: A 33-year-old man was admitted with a 4-week history of intermittent, right-sided chest pain. Two weeks before the incident, he had completed a 10-day course of levofloxacin for a presumed right-sided pneumonia without much improvement. He denied any dyspnea, cough, sputum production, hemoptysis, night sweats, or weight loss. He was an active smoker with a 20-pack-year smoking history and 1-year history of vaping nicotine.
Assuntos
Carcinoma/diagnóstico , Neoplasias Hepáticas/diagnóstico , Neoplasias Pulmonares/diagnóstico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Broncoscopia , Carboplatina/administração & dosagem , Carcinoma/tratamento farmacológico , Carcinoma/genética , Carcinoma/secundário , Etoposídeo/administração & dosagem , Evolução Fatal , Rearranjo Gênico/genética , Humanos , Falência Hepática/etiologia , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Linfadenopatia , Masculino , Proteínas de Neoplasias/genética , Proteínas Nucleares/genética , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios X , Fatores de Transcrição/genética , Síndrome de Lise Tumoral/etiologiaRESUMO
Chronic myelogenous leukemia (CML) is characterized by the presence of the chromosomal abnormality t(9;22)(q34;q11), which is detected in more than 90% of cases. Despite great strides in our understanding of this disease, few predisposing etiologic factors have been identified. We report on the case of a 45-year-old man with Philadelphia chromosome-positive, BCR-ABL fusion-positive chronic-phase CML, whose brother had succumbed to the same disease 22 years earlier. While a coincidental familial occurrence cannot be excluded in this case, we believe that this report underscores the need for further investigation of possible unknown environmental or heritable etiologic factors in this disease.